Early-onset and late-onset Parkinson's disease exhibit a different profile of gait and posture features based on the Kinect.

Early-onset Gait Late-onset Parkinson’s disease Posture

Journal

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
ISSN: 1590-3478
Titre abrégé: Neurol Sci
Pays: Italy
ID NLM: 100959175

Informations de publication

Date de publication:
09 Aug 2023
Historique:
received: 05 06 2023
accepted: 03 08 2023
medline: 9 8 2023
pubmed: 9 8 2023
entrez: 9 8 2023
Statut: aheadofprint

Résumé

Gait and posture abnormalities are the common disabling motor symptoms in Parkinson's disease (PD). This study aims to investigate the differential characteristics of gait and posture in early-onset PD (EOPD) and late-onset PD (LOPD) using the Kinect depth camera. Eighty-eight participants, including two subgroups of 22 PD patients and two subgroups of 22 healthy controls (HC) matched for age, sex, and height, were enrolled. Gait and posture features were quantitatively assessed using a Kinect-based system. A two-way analysis of variance was used to compare the difference between different subgroups. EOPD had a significantly higher Gait score than LOPD (p = 0.031). Specifically, decreased swing phase (p = 0.034) was observed in the EOPD group. Although the Posture score was similar between the two groups, LOPD was characterized by an increased forward flexion angle of the trunk at the thorax (p = 0.042) and a decreased forward flexion angle of the head relative to the trunk (p = 0.009). Additionally, age-independent features were observed in both PD subgroups, and post hoc tests revealed that EOPD generally performed worse gait features. In comparison, LOPD was characterized by worse performance in posture features. EOPD and LOPD exhibit different profiles of gait and posture features. The phenotype-specific characteristics likely reflect the distinct neurodegenerative processes between them.

Identifiants

DOI: 10.1007/s10072-023-07009-y PMID: 37555875
pubmed: 37555875
doi: 10.1007/s10072-023-07009-y
pii: 10.1007/s10072-023-07009-y
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : the Science and Technology Commission of Shanghai Municipality
ID : 20dz1207203
Organisme : ALLERGAN SINGAPORE PTE LTD ("Allergan")
ID : SA-003745 / IIT-2019-10706
Organisme : ALLERGAN SINGAPORE PTE LTD ("Allergan")
ID : HX2005
Organisme : Shanghai Municipal Science and Technology Committee of Shanghai outstanding academic leaders' plan
ID : 20XD1403400

Informations de copyright

© 2023. Fondazione Società Italiana di Neurologia.

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Auteurs

Kangwen Peng (K)

Neurotoxin Research Center, Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of Ministry of Education, Neurological Department of Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.

Ludi Xie (L)

Neurotoxin Research Center, Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of Ministry of Education, Neurological Department of Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.

Ronghua Hong (R)

Department of Neurology and Neurological Rehabilitation, Shanghai Disabled Persons' Federation Key Laboratory of Intelligent Rehabilitation Assistive Devices and Technologies, Yangzhi Rehabilitation Hospital (Shanghai Sunshine Rehabilitation Center), School of Medicine, Tongji University, Shanghai, China.

Zhuang Wu (Z)

Neurotoxin Research Center, Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of Ministry of Education, Neurological Department of Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.

Hongkai Gu (H)

Neurotoxin Research Center, Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of Ministry of Education, Neurological Department of Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.

Yijing He (Y)

Neurotoxin Research Center, Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of Ministry of Education, Neurological Department of Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.

Ziwen Xing (Z)

Neurotoxin Research Center, Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of Ministry of Education, Neurological Department of Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.

Qiang Guan (Q)

Neurotoxin Research Center, Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of Ministry of Education, Neurological Department of Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.

Lizhen Pan (L)

Neurotoxin Research Center, Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of Ministry of Education, Neurological Department of Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.

Lingjing Jin (L)

Neurotoxin Research Center, Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of Ministry of Education, Neurological Department of Tongji Hospital, School of Medicine, Tongji University, Shanghai, China. lingjingjin@tongji.edu.cn.
Department of Neurology and Neurological Rehabilitation, Shanghai Disabled Persons' Federation Key Laboratory of Intelligent Rehabilitation Assistive Devices and Technologies, Yangzhi Rehabilitation Hospital (Shanghai Sunshine Rehabilitation Center), School of Medicine, Tongji University, Shanghai, China. lingjingjin@tongji.edu.cn.
Collaborative Innovation Center for Brain Science (Sponsored By Shanghai Blue Cross Brain Hospital Co., Ltd. and Shanghai Tongji University Education Development Foundation), Tongji University, Shanghai, China. lingjingjin@tongji.edu.cn.

Lixi Li (L)

Neurotoxin Research Center, Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of Ministry of Education, Neurological Department of Tongji Hospital, School of Medicine, Tongji University, Shanghai, China. lixili@tongji.edu.cn.
ORCID: 0000-0001-5844-3128

Classifications MeSH