Microbiota as the unifying factor behind the hallmarks of cancer.
Fecal microbiota transplantation
Gut microbiota
Hallmarks of cancer
Tumor microenvironment
Journal
Journal of cancer research and clinical oncology
ISSN: 1432-1335
Titre abrégé: J Cancer Res Clin Oncol
Pays: Germany
ID NLM: 7902060
Informations de publication
Date de publication:
Nov 2023
Nov 2023
Historique:
received:
05
05
2023
accepted:
01
08
2023
pubmed:
9
8
2023
medline:
9
8
2023
entrez:
9
8
2023
Statut:
ppublish
Résumé
The human microbiota is a complex ecosystem that colonizes body surfaces and interacts with host organ systems, especially the immune system. Since the composition of this ecosystem depends on a variety of internal and external factors, each individual harbors a unique set of microbes. These differences in microbiota composition make individuals either more or less susceptible to various diseases, including cancer. Specific microbes are associated with cancer etiology and pathogenesis and several mechanisms of how they drive the typical hallmarks of cancer were recently identified. Although most microbes reside in the distal gut, they can influence cancer initiation and progression in distant tissues, as well as modulate the outcomes of established cancer therapies. Here, we describe the mechanisms by which microbes influence carcinogenesis and discuss their current and potential future applications in cancer diagnostics and management.
Identifiants
pubmed: 37555952
doi: 10.1007/s00432-023-05244-6
pii: 10.1007/s00432-023-05244-6
pmc: PMC10590318
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
14429-14450Subventions
Organisme : Agentura Pro Zdravotnický Výzkum České Republiky
ID : NV19-03-00179
Organisme : Mikrobiologický Ústav, Akademie Věd České Republiky
ID : LQ200202105
Informations de copyright
© 2023. The Author(s).
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