Rosacea in children: a review.
Classification
Facial dermatoses
Inflammation
Pathogenesis
Pediatric rosacea
Treatment
Journal
European journal of pediatrics
ISSN: 1432-1076
Titre abrégé: Eur J Pediatr
Pays: Germany
ID NLM: 7603873
Informations de publication
Date de publication:
Oct 2023
Oct 2023
Historique:
received:
04
03
2023
accepted:
22
06
2023
revised:
07
03
2023
medline:
1
11
2023
pubmed:
9
8
2023
entrez:
9
8
2023
Statut:
ppublish
Résumé
Rosacea is a facial inflammatory disorder that shows an increasing incidence with age. While rosacea is common > 60 years of age, pediatric rosacea is uncommon. Diagnostic criteria are based on clinical symptoms. Laboratory investigations and histopathology are only needed to exclude other differential diagnoses. There are several subtypes such as erythemato-telangiectatic, papulo-pustular, periorificial, and granulomatous variants. In contrast to adult rosacea, phymatous subtypes do not belong to pediatric rosacea. A special subtype seen in infants and children is an idiopathic facial aseptic granuloma. Genetic and environmental factors contribute to its pathogenesis. Treatment options are in analogy to adult rosacea classified into topical and systemic drugs. In the case of oral tetracyclines, discoloration of teeth and impairment of enamel are possible adverse events. Pediatric rosacea belongs to the rosacea spectrum but has peculiarities compared to the adult subtype. • Rosacea is a chronic inflammatory disorder different from acne. • Rosacea gets more common with advanced age. • Pediatric rosacea is an uncommon subtype with peculiar clinical presentation. • Demodicosis is very rare in immunocompetent children.
Identifiants
pubmed: 37555972
doi: 10.1007/s00431-023-05083-0
pii: 10.1007/s00431-023-05083-0
doi:
Substances chimiques
Anti-Bacterial Agents
0
Tetracyclines
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
4323-4328Informations de copyright
© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
Références
van Zuuren EJ, Arents BWM, van der Linden MMD, Vermeulen S, Fedorowicz Z, Tan J (2021) Rosacea: new concepts in classification and treatment. Am J Clin Dermatol 22(4):457–465. https://doi.org/10.1007/s40257-021-00595-7
doi: 10.1007/s40257-021-00595-7
pubmed: 33759078
pmcid: 8200341
Goel NS, Burkhart CN, Morrell DS (2015) Pediatric periorificial dermatitis: clinical course and treatment outcomes in 222 patients. Pediatr Dermatol 32(3):333–336. https://doi.org/10.1111/pde.12534
doi: 10.1111/pde.12534
pubmed: 25847356
Nguyen V, Eichenfield LF (2006) Periorificial dermatitis in children and adolescents. J Am Acad Dermatol 55(5):781–785. https://doi.org/10.1016/j.jaad.2006.05.031
doi: 10.1016/j.jaad.2006.05.031
pubmed: 17052482
Boralevi F, Léauté-Labrèze C, Lepreux S, Barbarot S, Mazereeuw-Hautier J, Eschard C, Taïeb A; Groupe de Recherche Clinique en Dermatologie Pédiatrique (2007) Idiopathic facial aseptic granuloma: a multicentre prospective study of 30 cases. Br J Dermatol 156(4):705–708. https://doi.org/10.1111/j.1365-2133.2006.07741.x
doi: 10.1111/j.1365-2133.2006.07741.x
Chamaillard M, Mortemousque B, Boralevi F, Marques da Costa C, Aitali F, Taïeb A, Léauté-Labrèze C (2008) Cutaneous and ocular signs of childhood rosacea. Arch Dermatol 144(2):167–171. https://doi.org/10.1001/archdermatol.2007.50
doi: 10.1001/archdermatol.2007.50
pubmed: 18283173
Zitelli KB, Sheil AT, Fleck R, Schwentker A, Lucky AW (2015) Idiopathic facial aseptic granuloma: review of an evolving clinical entity. Pediatr Dermatol 32(4):e136–e139. https://doi.org/10.1111/pde.12571
doi: 10.1111/pde.12571
pubmed: 25847574
Léauté-Labrèze C, Chamaillard M (2007) Paediatric rosacea. Ann Dermatol Venereol 134(10 Pt 1):788–792. https://doi.org/10.1016/s0151-9638(07)92543-0
doi: 10.1016/s0151-9638(07)92543-0
pubmed: 17978725
Patrizi A, Neri I, Chieregato C, Misciali M (1997) Demodecidiosis in immunocompetent young children: report of eight cases. Dermatology 195:239–242. https://doi.org/10.1159/000245951
doi: 10.1159/000245951
pubmed: 9407170
Douglas A, Zaenglein AL (2019) A case series of demodicosis in children. Pediatr Dermatol 36(5):651–654. https://doi.org/10.1111/pde.13852
doi: 10.1111/pde.13852
pubmed: 31197860
Noguera-Morel L, Hernández-Martín A, Torrelo A (2021) Childhood rosacea and related disorders. Clin Exp Dermatol 46(3):430–443. https://doi.org/10.1111/ced.14419
doi: 10.1111/ced.14419
pubmed: 33217048
Nazir SA, Murphy S, Siatkowski RM, Chodosh J, Siatkowski RL (2004) Ocular rosacea in childhood. Am J Ophthalmol 137:138–144. https://doi.org/10.1016/s0002-9394(03)00890-0
doi: 10.1016/s0002-9394(03)00890-0
pubmed: 14700657
Knöpfel N, Gómez-Zubiaur A, Noguera-Morel L, Torrelo A, Hernandez-Martin A (2018) Ultrasound findings in idiopathic facial aseptic granuloma: case series and literature review. Pediatr Dermatol 35(3):397–400. https://doi.org/10.1111/pde.13324
doi: 10.1111/pde.13324
pubmed: 29120075
Neri I, Raone B, Dondi A, Misciali C, Patrizi A (2013) Should idiopathic facial aseptic granuloma be considered granulomatous rosacea? Report of three pediatric cases. Pediatr Dermatol 30(1):109–111. https://doi.org/10.1111/j.1525-1470.2011.01689.x
doi: 10.1111/j.1525-1470.2011.01689.x
pubmed: 22340024
Salerni G, Peralta R, Bertaina C, Gorosito M, Fernández-Bussy R (2020) Dermoscopy of idiopathic facial aseptic granuloma. Clin Exp Dermatol 45(5):605–606. https://doi.org/10.1111/ced.14174
doi: 10.1111/ced.14174
pubmed: 31919863
Crawford GH, Pelle M, James WD (2004) Rosacea: I. Etiology, pathogenesis, and subtype classification. J Am Acad Dermatol 51:327–341. https://doi.org/10.1016/j.jaad.2004.03.030
doi: 10.1016/j.jaad.2004.03.030
pubmed: 15337973
Aldrich N, Gerstenblith M, Fu P, Tuttle MS, Varma P, Gotow E, Cooper KD, Mann M, Popkin DL (2015) Genetic vs environmental factors that correlate with rosacea: a cohort-based survey of twins. JAMA Dermatol 151(11):1213–1219. https://doi.org/10.1001/jamadermatol.2015.2230
doi: 10.1001/jamadermatol.2015.2230
pubmed: 26307938
Zhu W, Hamblin MR, Wen X (2023) Role of the skin microbiota and intestinal microbiome in rosacea. Front Microbiol 14:1108661. https://doi.org/10.3389/fmicb.2023.1108661
doi: 10.3389/fmicb.2023.1108661
pubmed: 36846769
pmcid: 9950749
Sáez-de-Ocariz M, Suárez-Gutiérrez M, Migaud M, Farrill-Romanillos O, P, Casanova JL, Segura-Mendez NH, Orozco-Covarrubias L, Espinosa-Padilla SE, Puel A, Blancas-Galicia L (2020) Rosacea as a striking feature in family members with a STAT1 gain-of-function mutation. J Eur Acad Dermatol Venereol 34(6):e265–e267. https://doi.org/10.1111/jdv.16241
doi: 10.1111/jdv.16241
pubmed: 31991004
Ahn CS, Huang WW (2018) Rosacea pathogenesis. Dermatol Clin 36(2):81–86. https://doi.org/10.1016/j.det.2017.11.001
doi: 10.1016/j.det.2017.11.001
pubmed: 29499802
Amir Ali A, Vender R, Vender R (2019) The role of IL-17 in papulopustular rosacea and future directions. J Cutan Med Surg 23(6):635–641. https://doi.org/10.1177/1203475419867611
doi: 10.1177/1203475419867611
pubmed: 31402691
Yamasaki K, Gallo RL (2009) The molecular pathology of rosacea. J Dermatol Sci 55(2):77–81. https://doi.org/10.1016/j.jdermsci.2009.04.007
doi: 10.1016/j.jdermsci.2009.04.007
pubmed: 19481425
pmcid: 2745268
Zhou X, Su Y, Wu S, Wang H, Jiang R, Jiang X (2022) The temperature-sensitive receptors TRPV4 and TRPM8 have important roles in the pruritus of rosacea. J Dermatol Sci 108(2):68–76. https://doi.org/10.1016/j.jdermsci.2022.11.004
doi: 10.1016/j.jdermsci.2022.11.004
pubmed: 36517318
van Zuuren EJ, Fedorowicz Z (2015) Interventions for rosacea. JAMA 314(22):2403–2404. https://doi.org/10.1001/jama.2015.15287
doi: 10.1001/jama.2015.15287
pubmed: 26647262
Thiboutot DM, Fleischer AB, Del Rosso JQ, Graupe K (2008) Azelaic acid 15% gel once daily versus twice daily in papulopustular rosacea. J Drugs Dermatol 7(6):541–546. PMID: 18561584
pubmed: 18561584
Koçak M, Yağli S, Vahapoğlu G, Ekşioğlu M (2002) Permethrin 5% cream versus metronidazole 0.75% gel for the treatment of papulopustular rosacea. A randomized double-blind placebo-controlled study. Dermatology. 205(3):265–270. https://doi.org/10.1159/000065849
Noguera-Morel L, Gerlero P, Torrelo A, Hernández-Martín Á (2017) Ivermectin therapy for papulopustular rosacea and periorificial dermatitis in children: A series of 15 cases. J Am Acad Dermatol 76(3):567–570. https://doi.org/10.1016/j.jaad.2016.10.034
doi: 10.1016/j.jaad.2016.10.034
pubmed: 28212765
Schaller M, Gonser L, Belge K, Braunsdorf C, Nordin R, Scheu A, Borelli C (2017) Dual anti-inflammatory and anti-parasitic action of topical ivermectin 1% in papulopustular rosacea. J Eur Acad Dermatol Venereol 31(11):1907–1911. https://doi.org/10.1111/jdv.14437
doi: 10.1111/jdv.14437
pubmed: 28653460
Ollech A, Yousif R, Kruse L, Wagner A, Kenner-Bell B, Chamlin S, Yun D, Shen L, Vivar K, Reynolds M, Paller AS, Mancini AJ (2020) Topical calcineurin inhibitors for pediatric periorificial dermatitis. J Am Acad Dermatol 82(6):1409–1414. https://doi.org/10.1016/j.jaad.2020.01.064
doi: 10.1016/j.jaad.2020.01.064
pubmed: 32032693
Gonser LI, Gonser CE, Deuter C, Heister M, Zierhut M, Schaller M (2017) Systemic therapy of ocular and cutaneous rosacea in children. J Eur Acad Dermatol Venereol 31(10):1732–1738. https://doi.org/10.1111/jdv.14402
doi: 10.1111/jdv.14402
pubmed: 28621909
Schaller M, Kemény L, Havlickova B, Jackson JM, Ambroziak M, Lynde C, Gooderham M, Remenyik E, Del Rosso J, Weglowska J, Chavda R, Kerrouche N, Dirschka T, Johnson S (2020) A randomized phase 3b/4 study to evaluate concomitant use of topical ivermectin 1% cream and doxycycline 40-mg modified-release capsules, versus topical ivermectin 1% cream and placebo in the treatment of severe rosacea. J Am Acad Dermatol 82(2):336–343. https://doi.org/10.1016/j.jaad.2019.05.063
doi: 10.1016/j.jaad.2019.05.063
pubmed: 31150711
Kim SJ, Kim EH, Lee M, Baek JY, Lee JY, Shin JH, Lim SM, Kim MY, Jung I, Ahn JG, Kang CM, Kang JM (2022) Risk of dental discoloration and enamel dysplasia in children exposed to tetracycline and its derivatives. Yonsei Med J 63(12):1113–1120. https://doi.org/10.3349/ymj.2022.0388
doi: 10.3349/ymj.2022.0388
pubmed: 36444547
pmcid: 9760895
Levy M, Martin L, Bursztejn AC, Chiaverini C, Miquel J, Mahé E, Maruani A, Boralevi F; Groupe de Recherche de la Société Française de Dermatologie Pédiatrique (2020) Ivermectin safety in infants and children under 15 kg treated for scabies: a multicentric observational study. Br J Dermatol 182(4):1003–1006. https://doi.org/10.1111/bjd.18369
doi: 10.1111/bjd.18369
Cantarutti N, Claps A, Angelino G, Chessa L, Callea F, El Hachem M, Diociaiuti A, Finocchi A (2015) Multi-drugs resistant acne rosacea in a child affected by ataxia-telangiectasia: successful treatment with isotretinoin. Ital J Pediatr 41:23. https://doi.org/10.1186/s13052-015-0125-7
doi: 10.1186/s13052-015-0125-7
pubmed: 25881033
pmcid: 4432829
Léoni S, Mesplié N, Aitali F, Chamaillard M, Boralevi F, Marques da Costa C, Taïeb A, Léauté-Labrèze C, Colin J, Mortemousque B (2011) Le métronidazole, alternative thérapeutique des rosacées oculaires et cutanées de l’enfant [Metronidazole: alternative treatment for ocular and cutaneous rosacea in the pediatric population]. J Fr Ophtalmol 34(10):703–710. https://doi.org/10.1016/j.jfo.2011.07.008
doi: 10.1016/j.jfo.2011.07.008
pubmed: 21885154
Hasbún ZC, Ogueta CI, Dossi CT, Wortsman X (2019) Idiopathic facial aseptic granuloma: updated review of diagnostic and therapeutic difficulties. Actas Dermosifiliogr (Engl Ed) 110(8):637–641. https://doi.org/10.1016/j.ad.2019.01.005
doi: 10.1016/j.ad.2019.01.005
Blind E, Ropars N, Safa G (2018) Efficacité spectaculaire de l’ivermectine topique dans un cas de granulome facial aseptique idiopathique [Dramatic efficacy of topical ivermectin in idiopathic facial aseptic granuloma]. Ann Dermatol Venereol 145(12):792–794. https://doi.org/10.1016/j.annder.2018.07.019
doi: 10.1016/j.annder.2018.07.019
pubmed: 30197052
Sanchez-Espino LF, Sibbald C (2022) Idiopathic facial aseptic granuloma: report of successful treatment with low-dose isotretinoin in a pediatric patient with trisomy 21. JAAD Case Rep 24:88–90. https://doi.org/10.1016/j.jdcr.2022.04.018
doi: 10.1016/j.jdcr.2022.04.018
pubmed: 35647253
pmcid: 9136597