The consequences of neurodegenerative disease on neuron-astrocyte metabolic and redox interactions.
Alzheimer's disease
Antioxidants
Astrocyte
Cellular neuroscience
Glycolysis
Metabolism
Reactive oxygen species
Redox signalling
Journal
Neurobiology of disease
ISSN: 1095-953X
Titre abrégé: Neurobiol Dis
Pays: United States
ID NLM: 9500169
Informations de publication
Date de publication:
09 2023
09 2023
Historique:
received:
05
06
2023
revised:
24
07
2023
accepted:
05
08
2023
medline:
4
9
2023
pubmed:
10
8
2023
entrez:
9
8
2023
Statut:
ppublish
Résumé
Brain metabolic pathways relating to bioenergetic and redox homeostasis are closely linked, and deficits in these pathways are thought to occur in many neurodegenerative diseases. Astrocytes play important roles in both processes, and growing evidence suggests that neuron-astrocyte intercellular signalling ensures brain bioenergetic and redox homeostasis in health. Moreover, alterations to this crosstalk have been observed in the context of neurodegenerative pathology. In this review, we summarise the current understanding of how neuron-astrocyte interactions influence brain metabolism and antioxidant functions in health as well as during neurodegeneration. It is apparent that deleterious and adaptive protective responses alter brain metabolism in disease, and that knowledge of both may illuminate targets for future therapeutic interventions.
Identifiants
pubmed: 37558170
pii: S0969-9961(23)00270-X
doi: 10.1016/j.nbd.2023.106255
pii:
doi:
Types de publication
Review
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
106255Subventions
Organisme : Medical Research Council
Pays : United Kingdom
Informations de copyright
Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.