Catecholaminergic Polymorphic Ventricular Tachycardia: A Review of Therapeutic Strategies.
Catecholaminergic polymorphic ventricular tachycardia
Flecainide
RYR2-specific compounds
Sudden cardiac death
Therapeutic management
β-blockers
Journal
Cardiac electrophysiology clinics
ISSN: 1877-9190
Titre abrégé: Card Electrophysiol Clin
Pays: United States
ID NLM: 101549998
Informations de publication
Date de publication:
09 2023
09 2023
Historique:
medline:
11
8
2023
pubmed:
10
8
2023
entrez:
9
8
2023
Statut:
ppublish
Résumé
Catecholaminergic polymorphic ventricular tachycardia (CPVT) is an inherited arrhythmia syndrome characterized by bidirectional or polymorphic ventricular arrhythmia provoked by exercise or emotion. Most cases are caused by pathogenic variants in the gene encoding the cardiac ryanodine receptor (RYR2). The options for treating patients with CPVT have increased during the years, and evidence suggests that these have led to lower arrhythmic event rates. In addition, numerous potential new therapies are being investigated. In this review, we summarize the state of knowledge on both established and potential future treatment strategies for patients with CPVT and describe our approach to their management.
Identifiants
pubmed: 37558300
pii: S1877-9182(23)00039-4
doi: 10.1016/j.ccep.2023.04.002
pii:
doi:
Substances chimiques
Anti-Arrhythmia Agents
0
Ryanodine Receptor Calcium Release Channel
0
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
293-305Informations de copyright
Copyright © 2023 Elsevier Inc. All rights reserved.