Catechin-Functionalized Cationic Lipopolymer Based Multicomponent Nanomicelles for Lung-Targeting Delivery.
bioavailability
catechin
cationic lipopolymers
lung-targeting delivery
nano-micelle
Journal
Advanced materials (Deerfield Beach, Fla.)
ISSN: 1521-4095
Titre abrégé: Adv Mater
Pays: Germany
ID NLM: 9885358
Informations de publication
Date de publication:
09 Aug 2023
09 Aug 2023
Historique:
revised:
22
07
2023
received:
31
03
2023
pubmed:
10
8
2023
medline:
10
8
2023
entrez:
9
8
2023
Statut:
aheadofprint
Résumé
Catechins from green tea are one of the most effective natural compounds for cancer chemoprevention and have attracted extensive research. Cancer cell-selective apoptosis-inducing properties of catechins depend on efficient intracellular delivery. However, the low bioavailability limits the application of catechins. Herein, a nano-scaled micellar composite composed of catechin-functionalized cationic lipopolymer and serum albumin is constructed. Cationic liposomes tend to accumulate in the pulmonary microvasculature due to electrostatic effects and are able to deliver the micellar system intracellularly, thus improving the bioavailability of catechins. Albumin in the system acts as a biocompatible anti-plasma absorbent, forming complexes with positively charged lipopolymer under electrostatic interactions, contributing to prolonged in vivo retention. The physicochemical properties of the nano-micellar complexes are characterized, and the antitumor properties of catechin-functionalized materials are confirmed by reactive oxygen species (ROS), caspase-3, and cell apoptosis measurements. The role of each functional module, cationic polymeric liposome, and albumin is revealed by cell penetration, in vivo animal assays, etc. This multicomponent micellar nanocomposite has the potential to become an effective vehicle for the treatment of lung diseases such as pneumonia, lung tumors, sepsis-induced lung injury, etc. This study also demonstrates that it is a great strategy to create a delivery system that is both tissue-targeted and biologically active by combining cationic liposomes with the native bioactive compound catechins.
Identifiants
pubmed: 37558506
doi: 10.1002/adma.202302985
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2302985Subventions
Organisme : National Natural Science Foundation of China
ID : NSFC51973180
Organisme : Karolinska Institutet Ming Wai Lau Centre of Reparative Medicine
Organisme : City University of Hong Kong
ID : 7020028
Organisme : City University of Hong Kong
ID : 7005949
Organisme : City University of Hong Kong
ID : 9231412
Organisme : City University of Hong Kong
ID : 9231486
Organisme : Young scientists lifting project of Jiangsu Province, China
ID : TJ-2022-072
Informations de copyright
© 2023 Wiley-VCH GmbH.
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