Associations between chronic widespread pain, pressure pain thresholds, leptin, and metabolic factors in individuals with knee pain.
Chronic widespread pain
Leptin
Metabolic factors
Pressure pain thresholds
Journal
BMC musculoskeletal disorders
ISSN: 1471-2474
Titre abrégé: BMC Musculoskelet Disord
Pays: England
ID NLM: 100968565
Informations de publication
Date de publication:
09 Aug 2023
09 Aug 2023
Historique:
received:
01
03
2023
accepted:
02
08
2023
medline:
11
8
2023
pubmed:
10
8
2023
entrez:
9
8
2023
Statut:
epublish
Résumé
The aim was to study associations between chronic widespread pain, widespread pain sensitivity, leptin, and metabolic factors in individuals with knee pain. A secondary aim was to study these associations in a subgroup of individuals with normal BMI. This cross-sectional study included 265 individuals. The participants were categorised into three different pain groups: Chronic widespread pain (CWP), chronic regional pain (ChRP), or no chronic pain (NCP). The pressure pain thresholds (PPTs) were assessed using computerised pressure algometry. Low PPTs were defined as having PPTs in the lowest third of all tender points. Leptin and metabolic factors such as BMI, visceral fat area (VFA), lipids, and glucose were also assessed. Sixteen per cent reported CWP, 15% had low PPTs, and 4% fulfilled both criteria. Those who fulfilled the criteria for CWP were more often women, more obese, and had increased leptin levels. In logistic regression, adjusted for age and gender, leptin was associated with fulfilling criteria for CWP, OR 1.015 (95% CI 1.004-1.027, p = 0.008). In logistic regression, adjusted for age and gender, leptin was associated with low PPTs, OR 1.016 (95% CI 1.004-1.029, p = 0.012). Leptin was also associated with fulfilling both criteria, adjusted for age, sex, and visceral fat area (VFA), OR 1.030 (95% CI 1.001-1.060), p = 0.040. Leptin was associated with fulfilling the combined criteria for chronic widespread pain and low PPTs, even after adjusting for the visceral fat area (VFA). Longitudinal studies are needed to study the causal relationships between leptin and the development of widespread pain. clinicalTrials.gov Identifier: NCT04928170.
Identifiants
pubmed: 37559026
doi: 10.1186/s12891-023-06773-4
pii: 10.1186/s12891-023-06773-4
pmc: PMC10410998
doi:
Substances chimiques
Leptin
0
Banques de données
ClinicalTrials.gov
['NCT04928170']
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
639Informations de copyright
© 2023. BioMed Central Ltd., part of Springer Nature.
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