A genome-wide gene-environment interaction study of breast cancer risk for women of European ancestry.

Adult Female Humans Gene-Environment Interaction Genetic Predisposition to Disease Breast Neoplasms / etiology Bayes Theorem Genome-Wide Association Study Risk Factors Polymorphism, Single Nucleotide Case-Control Studies
Breast cancer European ancestry Gene-environment interactions Genetic epidemiology

Journal

Breast cancer research : BCR
ISSN: 1465-542X
Titre abrégé: Breast Cancer Res
Pays: England
ID NLM: 100927353

Informations de publication

Date de publication:
09 08 2023
Historique:
received: 05 04 2023
accepted: 27 07 2023
medline: 11 8 2023
pubmed: 10 8 2023
entrez: 9 8 2023
Statut: epublish

Résumé

Genome-wide studies of gene-environment interactions (G×E) may identify variants associated with disease risk in conjunction with lifestyle/environmental exposures. We conducted a genome-wide G×E analysis of ~ 7.6 million common variants and seven lifestyle/environmental risk factors for breast cancer risk overall and for estrogen receptor positive (ER +) breast cancer. Analyses were conducted using 72,285 breast cancer cases and 80,354 controls of European ancestry from the Breast Cancer Association Consortium. Gene-environment interactions were evaluated using standard unconditional logistic regression models and likelihood ratio tests for breast cancer risk overall and for ER + breast cancer. Bayesian False Discovery Probability was employed to assess the noteworthiness of each SNP-risk factor pairs. Assuming a 1 × 10 Overall, the contribution of G×E interactions to the heritability of breast cancer is very small. At the population level, multiplicative G×E interactions do not make an important contribution to risk prediction in breast cancer.

Sections du résumé

BACKGROUND
Genome-wide studies of gene-environment interactions (G×E) may identify variants associated with disease risk in conjunction with lifestyle/environmental exposures. We conducted a genome-wide G×E analysis of ~ 7.6 million common variants and seven lifestyle/environmental risk factors for breast cancer risk overall and for estrogen receptor positive (ER +) breast cancer.
METHODS
Analyses were conducted using 72,285 breast cancer cases and 80,354 controls of European ancestry from the Breast Cancer Association Consortium. Gene-environment interactions were evaluated using standard unconditional logistic regression models and likelihood ratio tests for breast cancer risk overall and for ER + breast cancer. Bayesian False Discovery Probability was employed to assess the noteworthiness of each SNP-risk factor pairs.
RESULTS
Assuming a 1 × 10
CONCLUSIONS
Overall, the contribution of G×E interactions to the heritability of breast cancer is very small. At the population level, multiplicative G×E interactions do not make an important contribution to risk prediction in breast cancer.

Identifiants

DOI: 10.1186/s13058-023-01691-8 PMID: 37559094 PMC: PMC10411002
pubmed: 37559094
doi: 10.1186/s13058-023-01691-8
pii: 10.1186/s13058-023-01691-8
pmc: PMC10411002
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't Research Support, N.I.H., Intramural Research Support, U.S. Gov't, Non-P.H.S. Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

93

Subventions

Organisme : NCI NIH HHS
ID : HHSN261201800015I
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA097396
Pays : United States
Organisme : NIA NIH HHS
ID : HHSN271201100004C
Pays : United States
Organisme : NCI NIH HHS
ID : R35 CA253187
Pays : United States
Organisme : WHI NIH HHS
ID : HHSN268201100004C
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA164973
Pays : United States
Organisme : NCI NIH HHS
ID : UM1 CA186107
Pays : United States
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ID : P30 CA068485
Pays : United States
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Pays : United States
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ID : U01 CA098758
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA100374
Pays : United States
Organisme : Intramural NIH HHS
ID : Z01 ES044005
Pays : United States
Organisme : NCI NIH HHS
ID : UM1 CA164917
Pays : United States
Organisme : WHI NIH HHS
ID : HHSN268201100001C
Pays : United States
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : NCI NIH HHS
ID : HHSN261201800032I
Pays : United States
Organisme : NCI NIH HHS
ID : U19 CA148112
Pays : United States
Organisme : NCI NIH HHS
ID : P50 CA058223
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA132839
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA177150
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA128978
Pays : United States
Organisme : NCI NIH HHS
ID : HHSN261201800009I
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA176726
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA054281
Pays : United States
Organisme : Intramural NIH HHS
ID : Z01 CP010119
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA116167
Pays : United States
Organisme : NCI NIH HHS
ID : P50 CA116201
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA033572
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA023100
Pays : United States
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ID : U19 CA055075
Pays : United States
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ID : R01 CA192393
Pays : United States
Organisme : NCCDPHP CDC HHS
ID : NU58DP006344
Pays : United States
Organisme : NCI NIH HHS
ID : U19 CA148065
Pays : United States
Organisme : Intramural NIH HHS
ID : Z01 ES049030
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA176785
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201100046C
Pays : United States
Organisme : WHI NIH HHS
ID : HHSN268201100003C
Pays : United States
Organisme : NCI NIH HHS
ID : P01 CA087969
Pays : United States
Organisme : NCI NIH HHS
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Pays : United States
Organisme : NCI NIH HHS
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Pays : United States
Organisme : WHI NIH HHS
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Pays : United States
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Pays : United States
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Pays : United States
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Pays : United States
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Pays : United States
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Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA063464
Pays : United States
Organisme : Intramural NIH HHS
ID : Z01 ES049033
Pays : United States

Informations de copyright

© 2023. BioMed Central Ltd., part of Springer Nature.

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Auteurs

Pooja Middha (P)

Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany. pooja.middha@ucsf.edu.

Xiaoliang Wang (X)

Department of Epidemiology, University of Washington School of Public Health, Seattle, WA, USA.
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

Sabine Behrens (S)

Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.

Manjeet K Bolla (MK)

Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, UK.

Qin Wang (Q)

Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, UK.

Joe Dennis (J)

Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, UK.

Kyriaki Michailidou (K)

Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, UK.
Biostatistics Unit, The Cyprus Institute of Neurology and Genetics, Nicosia, Cyprus.

Thomas U Ahearn (TU)

Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

Irene L Andrulis (IL)

Fred A. Litwin Center for Cancer Genetics, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, ON, Canada.
Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada.

Hoda Anton-Culver (H)

Department of Medicine, Genetic Epidemiology Research Institute, University of California Irvine, Irvine, CA, USA.

Volker Arndt (V)

Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.

Kristan J Aronson (KJ)

Department of Public Health Sciences, and Cancer Research Institute, Queen's University, Kingston, ON, Canada.

Paul L Auer (PL)

Division of Biostatistics, Institute for Health and Equity, and Cancer Center, Medical College of Wisconsin, Milwaukee, WI, USA.

Annelie Augustinsson (A)

Oncology, Clinical Sciences in Lund, Lund University, Lund, Sweden.

Thaïs Baert (T)

Department of Oncology, Leuven Multidisciplinary Breast Center, Leuven Cancer Institute, University Hospitals Leuven, Leuven, Belgium.

Laura E Beane Freeman (LEB)

Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

Heiko Becher (H)

Institute of Medical Biometry and Epidemiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Matthias W Beckmann (MW)

Department of Gynecology and Obstetrics, Comprehensive Cancer Center Erlangen-EMN, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany.

Javier Benitez (J)

Human Genetics Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.
Centre for Biomedical Network Research on Rare Diseases (CIBERER), Instituto de Salud Carlos III, Madrid, Spain.

Stig E Bojesen (SE)

Copenhagen General Population Study, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark.
Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark.
Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Hiltrud Brauch (H)

Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany.
iFIT-Cluster of Excellence, University of Tübingen, Tübingen, Germany.
German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Partner Site Tübingen, Tübingen, Germany.

Hermann Brenner (H)

Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Division of Preventive Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg, Germany.
German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.

Angela Brooks-Wilson (A)

Canada's Michael Smith Genome Sciences Centre, BC Cancer, Vancouver, BC, Canada.

Daniele Campa (D)

Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Department of Biology, University of Pisa, Pisa, Italy.

Federico Canzian (F)

Genomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany.

Angel Carracedo (A)

Genomic Medicine Group, International Cancer Genetics and Epidemiology Group, Fundación Pública Galega de Medicina Xenómica, Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), Complejo Hospitalario Universitario de Santiago, SERGAS, Santiago de Compostela, Spain.
Grupo de Medicina Xenómica, Centro de Investigación en Red de Enfermedades Raras (CIBERER) y Centro Nacional de Genotipado (CEGEN-PRB2), Universidad de Santiago de Compostela, Santiago de Compostela, Spain.

Jose E Castelao (JE)

Oncology and Genetics Unit, Instituto de Investigación Sanitaria Galicia Sur (IISGS), Xerencia de Xestion Integrada de Vigo-SERGAS, Vigo, Spain.

Stephen J Chanock (SJ)

Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

Georgia Chenevix-Trench (G)

Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.

Emilie Cordina-Duverger (E)

Team 'Exposome and Heredity', CESP, Gustave Roussy, INSERM, University Paris-Saclay, UVSQ, Villejuif, France.

Fergus J Couch (FJ)

Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.

Angela Cox (A)

Department of Oncology and Metabolism, Sheffield Institute for Nucleic Acids (SInFoNiA), University of Sheffield, Sheffield, UK.

Simon S Cross (SS)

Academic Unit of Pathology, Department of Neuroscience, University of Sheffield, Sheffield, UK.

Kamila Czene (K)

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.

Laure Dossus (L)

Nutrition and Metabolism Section, International Agency for Research on Cancer (IARC-WHO), Lyon, France.

Pierre-Antoine Dugué (PA)

Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, VIC, Australia.
Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, VIC, Australia.

A Heather Eliassen (AH)

Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.

Mikael Eriksson (M)

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.

D Gareth Evans (DG)

Division of Evolution and Genomic Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, School of Biological Sciences, University of Manchester, Manchester, UK.
North West Genomics Laboratory Hub, Manchester Centre for Genomic Medicine, Manchester Academic Health Science Centre, St Mary's Hospital, Manchester University NHS Foundation Trust, Manchester, UK.

Peter A Fasching (PA)

Department of Gynecology and Obstetrics, Comprehensive Cancer Center Erlangen-EMN, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany.

Jonine D Figueroa (JD)

Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Usher Institute of Population Health Sciences and Informatics, The University of Edinburgh, Edinburgh, UK.
Cancer Research UK Edinburgh Centre, The University of Edinburgh, Edinburgh, UK.

Olivia Fletcher (O)

The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, UK.

Henrik Flyger (H)

Department of Breast Surgery, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark.

Marike Gabrielson (M)

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.

Manuela Gago-Dominguez (M)

Genomic Medicine Group, International Cancer Genetics and Epidemiology Group, Fundación Pública Galega de Medicina Xenómica, Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), Complejo Hospitalario Universitario de Santiago, SERGAS, Santiago de Compostela, Spain.

Graham G Giles (GG)

Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, VIC, Australia.
Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, VIC, Australia.
Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC, Australia.

Anna González-Neira (A)

Human Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.

Felix Grassmann (F)

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Institute for Clinical Research and Systems Medicine, Health and Medical University, Potsdam, Germany.

Anne Grundy (A)

Department of Public Health Sciences, Queen's University, Kingston, ON, Canada.

Pascal Guénel (P)

Team 'Exposome and Heredity', CESP, Gustave Roussy, INSERM, University Paris-Saclay, UVSQ, Villejuif, France.

Christopher A Haiman (CA)

Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

Niclas Håkansson (N)

Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.

Per Hall (P)

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Department of Oncology, Södersjukhuset, Stockholm, Sweden.

Ute Hamann (U)

Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany.

Susan E Hankinson (SE)

Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Department of Biostatistics and Epidemiology, University of Massachusetts, Amherst, Amherst, MA, USA.

Elaine F Harkness (EF)

Division of Informatics, Imaging and Data Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK.
Nightingale and Genesis Prevention Centre, Wythenshawe Hospital, Manchester University NHS Foundation Trust, Manchester, UK.
NIHR Manchester Biomedical Research Unit, Manchester Academic Health Science Centre, Manchester University NHS Foundation Trust, Manchester, UK.

Bernd Holleczek (B)

Saarland Cancer Registry, Saarbrücken, Germany.

Reiner Hoppe (R)

Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany.
University of Tübingen, Tübingen, Germany.

John L Hopper (JL)

Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC, Australia.

Richard S Houlston (RS)

Division of Genetics and Epidemiology, The Institute of Cancer Research, London, UK.

Anthony Howell (A)

Division of Cancer Sciences, University of Manchester, Manchester, UK.

David J Hunter (DJ)

Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Nuffield Department of Population Health, University of Oxford, Oxford, UK.

Christian Ingvar (C)

Surgery, Clinical Sciences in Lund, Lund University, Lund, Sweden.

Karolin Isaksson (K)

Department of Surgery, Kristianstad Hospital, Kristianstad, Sweden.

Helena Jernström (H)

Oncology, Clinical Sciences in Lund, Lund University, Lund, Sweden.

Esther M John (EM)

Department of Epidemiology and Population Health, Stanford University School of Medicine, Stanford, CA, USA.
Division of Oncology, Department of Medicine, Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, USA.

Michael E Jones (ME)

Division of Genetics and Epidemiology, The Institute of Cancer Research, London, UK.

Rudolf Kaaks (R)

Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.

Renske Keeman (R)

Division of Molecular Pathology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.

Cari M Kitahara (CM)

Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.

Yon-Dschun Ko (YD)

Department of Internal Medicine, Johanniter GmbH Bonn, Johanniter Krankenhaus, Bonn, Germany.

Stella Koutros (S)

Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

Allison W Kurian (AW)

Department of Epidemiology and Population Health, Stanford University School of Medicine, Stanford, CA, USA.
Division of Oncology, Department of Medicine, Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, USA.

James V Lacey (JV)

Department of Computational and Quantitative Medicine, City of Hope, Duarte, CA, USA.
City of Hope Comprehensive Cancer Center, City of Hope, Duarte, CA, USA.

Diether Lambrechts (D)

Laboratory for Translational Genetics, Department of Human Genetics, KU Leuven, Leuven, Belgium.
VIB Center for Cancer Biology, VIB, Leuven, Belgium.

Nicole L Larson (NL)

Department of Quantitative Health Sciences, Division of Epidemiology, Mayo Clinic, Rochester, MN, USA.

Susanna Larsson (S)

Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.

Loic Le Marchand (L)

Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI, USA.

Flavio Lejbkowicz (F)

Clalit National Cancer Control Center, Carmel Medical Center and Technion Faculty of Medicine, Haifa, Israel.

Shuai Li (S)

Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, UK.
Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, VIC, Australia.
Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC, Australia.

Martha Linet (M)

Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.

Jolanta Lissowska (J)

Department of Cancer Epidemiology and Prevention, M. Sklodowska-Curie National Research Oncology Institute, Warsaw, Poland.

Maria Elena Martinez (ME)

Moores Cancer Center and Herbert Wertheim School of Public Health and Human Longevity Science, University of California, San Diego, La Jolla, CA, USA.

Tabea Maurer (T)

Cancer Epidemiology Group, University Cancer Center Hamburg (UCCH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Anna Marie Mulligan (AM)

Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.
Laboratory Medicine Program, University Health Network, Toronto, ON, Canada.

Claire Mulot (C)

INSERM UMR-S1138. CRB EPIGENETEC, Université Paris Cité, Paris, France.

Rachel A Murphy (RA)

School of Population and Public Health, University of British Columbia, Vancouver, BC, Canada.
Cancer Control Research, BC Cancer, Vancouver, BC, Canada.

William G Newman (WG)

Division of Evolution and Genomic Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, School of Biological Sciences, University of Manchester, Manchester, UK.
North West Genomics Laboratory Hub, Manchester Centre for Genomic Medicine, Manchester Academic Health Science Centre, St Mary's Hospital, Manchester University NHS Foundation Trust, Manchester, UK.

Sune F Nielsen (SF)

Copenhagen General Population Study, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark.
Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark.

Børge G Nordestgaard (BG)

Copenhagen General Population Study, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark.
Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark.
Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Aaron Norman (A)

Department of Quantitative Health Sciences, Division of Epidemiology, Mayo Clinic, Rochester, MN, USA.

Katie M O'Brien (KM)

Epidemiology Branch, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC, USA.

Janet E Olson (JE)

Department of Quantitative Health Sciences, Division of Epidemiology, Mayo Clinic, Rochester, MN, USA.

Alpa V Patel (AV)

Department of Population Science, American Cancer Society, Atlanta, GA, USA.

Ross Prentice (R)

Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

Erika Rees-Punia (E)

Department of Population Science, American Cancer Society, Atlanta, GA, USA.

Gad Rennert (G)

Clalit National Cancer Control Center, Carmel Medical Center and Technion Faculty of Medicine, Haifa, Israel.

Valerie Rhenius (V)

Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, UK.

Kathryn J Ruddy (KJ)

Department of Oncology, Mayo Clinic, Rochester, MN, USA.

Dale P Sandler (DP)

Epidemiology Branch, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC, USA.

Christopher G Scott (CG)

Department of Quantitative Health Sciences, Division of Clinical Trials and Biostatistics, Mayo Clinic, Rochester, MN, USA.

Mitul Shah (M)

Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, UK.

Xiao-Ou Shu (XO)

Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA.

Ann Smeets (A)

Department of Surgical Oncology, University Hospitals Leuven, Leuven, Belgium.

Melissa C Southey (MC)

Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, VIC, Australia.
Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, VIC, Australia.
Department of Clinical Pathology, The University of Melbourne, Melbourne, VIC, Australia.

Jennifer Stone (J)

Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC, Australia.
Genetic Epidemiology Group, School of Population and Global Health, University of Western Australia, Perth, WA, Australia.

Rulla M Tamimi (RM)

Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Department of Population Health Sciences, Weill Cornell Medicine, New York, NY, USA.

Jack A Taylor (JA)

Epidemiology Branch, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC, USA.
Epigenetic and Stem Cell Biology Laboratory, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC, USA.

Lauren R Teras (LR)

Department of Population Science, American Cancer Society, Atlanta, GA, USA.

Katarzyna Tomczyk (K)

The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, UK.

Melissa A Troester (MA)

Department of Epidemiology, Gillings School of Global Public Health and UNC Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Thérèse Truong (T)

Team 'Exposome and Heredity', CESP, Gustave Roussy, INSERM, University Paris-Saclay, UVSQ, Villejuif, France.

Celine M Vachon (CM)

Department of Quantitative Health Sciences, Division of Epidemiology, Mayo Clinic, Rochester, MN, USA.

Sophia S Wang (SS)

Department of Computational and Quantitative Medicine, City of Hope, Duarte, CA, USA.
City of Hope Comprehensive Cancer Center, City of Hope, Duarte, CA, USA.

Clarice R Weinberg (CR)

Biostatistics and Computational Biology Branch, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC, USA.

Hans Wildiers (H)

Department of Oncology, Leuven Multidisciplinary Breast Center, Leuven Cancer Institute, University Hospitals Leuven, Leuven, Belgium.

Walter Willett (W)

Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.

Stacey J Winham (SJ)

Division of Computational Biology, Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA.

Alicja Wolk (A)

Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.

Xiaohong R Yang (XR)

Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

M Pilar Zamora (MP)

Servicio de Oncología Médica, Hospital Universitario La Paz, Madrid, Spain.

Wei Zheng (W)

Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA.

Argyrios Ziogas (A)

Department of Medicine, Genetic Epidemiology Research Institute, University of California Irvine, Irvine, CA, USA.

Alison M Dunning (AM)

Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, UK.

Paul D P Pharoah (PDP)

Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, UK.
Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, UK.

Montserrat García-Closas (M)

Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

Marjanka K Schmidt (MK)

Division of Molecular Pathology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Division of Psychosocial Research and Epidemiology, The Netherlands Cancer Institute - Antoni Van Leeuwenhoek Hospital, Amsterdam, the Netherlands.

Peter Kraft (P)

Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Program in Genetic Epidemiology and Statistical Genetics, Harvard T.H. Chan School of Public Health, Boston, MA, USA.

Roger L Milne (RL)

Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, VIC, Australia.
Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, VIC, Australia.
Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC, Australia.

Sara Lindström (S)

Department of Epidemiology, University of Washington School of Public Health, Seattle, WA, USA.
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

Douglas F Easton (DF)

Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, UK.
Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, UK.

Jenny Chang-Claude (J)

Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Cancer Epidemiology Group, University Cancer Center Hamburg (UCCH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › A genome-wide gene-environment interaction...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › A genome-wide gene-environment interaction...
questionsmedicales.fr › Phénomènes génétiques › Phénotype › Interaction entre gènes et environnement › A genome-wide gene-environment interaction...
questionsmedicales.fr › Phénomènes génétiques › Génotype › Prédisposition génétique à une maladie › A genome-wide gene-environment interaction...
questionsmedicales.fr › Maladies de la peau et du tissu conjonctif › Maladies de la peau › Maladies du sein › Tumeurs du sein › A genome-wide gene-environment interaction...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Probabilité › Théorème de Bayes › A genome-wide gene-environment interaction...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Épidémiologie moléculaire › Étude d'association pangénomique › A genome-wide gene-environment interaction...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Probabilité › Risque › Facteurs de risque › A genome-wide gene-environment interaction...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Polymorphisme génétique › Polymorphisme de nucléotide simple › A genome-wide gene-environment interaction...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études cas-témoins › A genome-wide gene-environment interaction...