Atypical Hemolytic-Uremic Syndrome: Genetic Basis, Clinical Manifestations, and a Multidisciplinary Approach to Management.
atypical hemolytic uremic syndrome
complications
eculizumab
extra-renal manifestations
plasma exchange
Journal
Journal of multidisciplinary healthcare
ISSN: 1178-2390
Titre abrégé: J Multidiscip Healthc
Pays: New Zealand
ID NLM: 101512691
Informations de publication
Date de publication:
2023
2023
Historique:
received:
12
05
2023
accepted:
26
07
2023
medline:
10
8
2023
pubmed:
10
8
2023
entrez:
10
8
2023
Statut:
epublish
Résumé
Hemolytic uremic syndrome (HUS) is a thrombotic microangiopathy (TMA) defined by the triad of hemolytic anemia, thrombocytopenia, and acute kidney injury. Microthrombi develop in the glomerular capillaries secondary to endothelial damage and exert shear stress on red blood cells, consume platelets, and contribute to renal dysfunction and failure. Per current understanding of pathophysiology, HUS is classified into infectious, secondary, and atypical disease. The most common etiology is infectious sequelae of Shiga toxin-producing
Identifiants
pubmed: 37560408
doi: 10.2147/JMDH.S245620
pii: 245620
pmc: PMC10408684
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
2233-2249Informations de copyright
© 2023 Yerigeri et al.
Déclaration de conflit d'intérêts
Prof. Dr. Olivia Boyer reports personal fees from Alexion, during the conduct of the study; personal fees from Alnylam, CSL/Vifor, and Purespring, outside the submitted work. The authors report no other conflicts of interest in this work.
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