Genetic Programs Between Steroid-Sensitive and Steroid-Insensitive Interstitial Lung Disease.
Corticosteroids
Cryptogenic organizing pneumonia
Idiopathic pulmonary fibrosis
Inflammation
Interstitial lung disease
Journal
Inflammation
ISSN: 1573-2576
Titre abrégé: Inflammation
Pays: United States
ID NLM: 7600105
Informations de publication
Date de publication:
Dec 2023
Dec 2023
Historique:
accepted:
27
06
2023
medline:
27
11
2023
pubmed:
10
8
2023
entrez:
10
8
2023
Statut:
ppublish
Résumé
The effectiveness of corticosteroids (GCs) varies greatly in interstitial lung diseases (ILDs). In this study, we aimed to compare the gene expression profiles of patients with cryptogenic organizing pneumonia (COP), idiopathic pulmonary fibrosis (IPF), and non-specific interstitial pneumonia (NSIP) and identify the molecules and pathways responsible for GCs sensitivity in ILDs. Three datasets (GSE21411, GSE47460, and GSE32537) were selected. Differentially expressed genes (DEGs) among COP, IPF, NSIP, and healthy control (CTRL) groups were identified. Functional enrichment analysis and protein-protein interaction network analysis were performed to examine the potential functions of DEGs. There were 128 DEGs when COP versus CTRL, 257 DEGs when IPF versus CTRL, 205 DEGs when NSIP versus CTRL, and 270 DEGs when COP versus IPF. The DEGs in different ILDs groups were mainly enriched in the inflammatory response. Further pathway analysis showed that "interleukin (IL)-17 signaling pathway" (hsa04657) and "tumor necrosis factor (TNF) signaling pathway" were associated with different types of ILDs. A total of 10 genes associated with inflammatory response were identified as hub genes and their expression levels in the IPF group were higher than those in the COP group. Finally, we identified two GCs' response-related differently expressed genes (FOSL1 and DDIT4). Our bioinformatics analysis demonstrated that the inflammatory response played a pathogenic role in the progression of ILDs. We also illustrated that the inflammatory reaction was more severe in the IPF group compared to the COP group and identified two GCs' response-related differently expressed genes (FOSL1 and DDIT4) in ILDs.
Identifiants
pubmed: 37561311
doi: 10.1007/s10753-023-01866-7
pii: 10.1007/s10753-023-01866-7
pmc: PMC10673734
doi:
Substances chimiques
Steroids
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2120-2131Subventions
Organisme : national natural science foundation of china
ID : No. 81973986
Organisme : national natural science foundation of china
ID : 81570033
Organisme : national natural science foundation of china
ID : 82070032
Organisme : national major science and technology projects of china
ID : (2017ZX10103004
Informations de copyright
© 2023. The Author(s).
Références
Br J Radiol. 2009 Mar;82(975):212-8
pubmed: 19064594
Pharmaceutics. 2019 Sep 29;11(10):
pubmed: 31569594
Respir Res. 2020 Jun 30;21(1):165
pubmed: 32605572
Semin Respir Crit Care Med. 2016 Jun;37(3):378-94
pubmed: 27231862
Methods Enzymol. 2006;411:352-69
pubmed: 16939800
Adv Exp Med Biol. 2016;911:77-85
pubmed: 26987326
Respir Res. 2013 Aug 02;14:80
pubmed: 23915349
Ther Adv Respir Dis. 2008 Apr;2(2):75-93
pubmed: 19124361
Bioinformatics. 2008 May 1;24(9):1154-60
pubmed: 18325927
Am J Respir Crit Care Med. 2013 Sep 15;188(6):733-48
pubmed: 24032382
Lancet. 2009 Jul 18;374(9685):222-8
pubmed: 19570573
Thorax. 2004 Aug;59(8):687-93
pubmed: 15282390
Prog Neuropsychopharmacol Biol Psychiatry. 2018 Mar 2;82:136-168
pubmed: 29180230
Respir Med. 2011 Feb;105(2):292-7
pubmed: 21144722
Sci Transl Med. 2013 Oct 2;5(205):205ra136
pubmed: 24089408
Clin Exp Allergy. 2017 Jul;47(7):890-899
pubmed: 28493293
Immunol Lett. 2015 Feb;163(2):179-86
pubmed: 25540922
Am J Physiol Lung Cell Mol Physiol. 2020 Jan 1;318(1):L98-L111
pubmed: 31617731
PLoS One. 2013 Aug 14;8(8):e71059
pubmed: 23967151
J Proteome Res. 2017 Oct 6;16(10):3753-3765
pubmed: 28920441
Respirology. 2016 Feb;21(2):259-68
pubmed: 26564810
Respir Med. 2019 Feb;147:79-91
pubmed: 30704705
Respir Med. 2013 Sep;107(9):1444-52
pubmed: 23831213
Eur Respir J. 2006 Aug;28(2):422-46
pubmed: 16880372
Respirology. 2018 Nov;23(11):1041-1048
pubmed: 30011421
J Neurochem. 2002 Mar;80(6):1089-94
pubmed: 11953459
Respir Res. 2018 Aug 15;19(1):153
pubmed: 30111332
JAMA. 2018 Jun 12;319(22):2299-2307
pubmed: 29800034
Biomed Pharmacother. 2019 Oct;118:109380
pubmed: 31545224
BMC Bioinformatics. 2005 Nov 04;6:265
pubmed: 16271137
Ann Am Thorac Soc. 2014 Jan;11(1):87-91
pubmed: 24460438
Steroids. 2017 Nov;127:24-30
pubmed: 28866045
Mol Cancer Res. 2014 Jun;12(6):867-77
pubmed: 24615339
N Engl J Med. 2012 May 24;366(21):1968-77
pubmed: 22607134
Am J Respir Cell Mol Biol. 2008 Aug;39(2):208-17
pubmed: 18314542
Cochrane Database Syst Rev. 2003;(3):CD002880
pubmed: 12917934
Chin Med J (Engl). 2020 Mar 5;133(5):542-551
pubmed: 32053571
Nat Biotechnol. 2006 Sep;24(9):1151-61
pubmed: 16964229
JCI Insight. 2016 Dec 8;1(20):e90558
pubmed: 27942595
Eur Respir J. 2016 Oct;48(4):1052-1062
pubmed: 27540019