Long-term nephrotoxicity in irradiated pediatric kidney tumor survivors: A systematic review.


Journal

Pediatric blood & cancer
ISSN: 1545-5017
Titre abrégé: Pediatr Blood Cancer
Pays: United States
ID NLM: 101186624

Informations de publication

Date de publication:
11 2023
Historique:
revised: 01 08 2023
received: 20 09 2022
accepted: 02 08 2023
medline: 26 9 2023
pubmed: 10 8 2023
entrez: 10 8 2023
Statut: ppublish

Résumé

Nephrotoxicity can occur as a side effect after treatment for kidney tumor in childhood. The use of radiotherapy (RT) has a potential additional effect. A systematic electronic literature search that combined childhood kidney cancer with different treatments and nephrotoxicity terms was performed in EMBASE. Studies were included based on the reporting of nephrotoxicity occurrence after treatment for kidney tumor during pediatric age, with 75% of participants being under the age of 25 years at the time of diagnosis, and having been treated with any type of kidney surgery, chemotherapy, and/or RT. A pooled analysis did not show significant difference in estimated glomerular filtration rate between the group of patients who received RT compared with the group treated without RT (SMD -0.11 [95% CI -1.07-0.84] p = .733). The current literature suggests that the use of RT does not have a significant impact on the decline of kidney function as independent factor.

Identifiants

pubmed: 37561390
doi: 10.1002/pbc.30624
doi:

Types de publication

Systematic Review Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

e30624

Informations de copyright

© 2023 The Authors. Pediatric Blood & Cancer published by Wiley Periodicals LLC.

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Auteurs

Raquel Dávila Fajardo (R)

Department of Radiation Oncology, University Medical Center Utrecht, Utrecht, The Netherlands.
Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.

Paulien Raymakers-Janssen (P)

Department of Pediatric Intensive Care, University Medical Center Utrecht, Utrecht, The Netherlands.

Martine van Grotel (M)

Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.

Roelie M van Wösten-van Asperen (RM)

Department of Pediatric Intensive Care, University Medical Center Utrecht, Utrecht, The Netherlands.

Christianus H Terhaard (CH)

Department of Radiation Oncology, University Medical Center Utrecht, Utrecht, The Netherlands.

Marc R Lilien (MR)

Department of Pediatric Nephrology, University Medical Center Utrecht, Utrecht, The Netherlands.

Marry M van den Heuvel-Eibrink (MM)

Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.

Geert O Janssens (GO)

Department of Radiation Oncology, University Medical Center Utrecht, Utrecht, The Netherlands.
Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.

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