PRO-2000 exhibits SARS-CoV-2 antiviral activity by interfering with spike-heparin binding.
Antiviral
Covid-19
Heparan sulfate
Polyanionic
Spike
Journal
Antiviral research
ISSN: 1872-9096
Titre abrégé: Antiviral Res
Pays: Netherlands
ID NLM: 8109699
Informations de publication
Date de publication:
09 2023
09 2023
Historique:
received:
02
06
2023
revised:
29
07
2023
accepted:
06
08
2023
medline:
29
8
2023
pubmed:
11
8
2023
entrez:
10
8
2023
Statut:
ppublish
Résumé
Here, we report on the anti-SARS-CoV-2 activity of PRO-2000, a sulfonated polyanionic compound. In Vero cells infected with the Wuhan, alpha, beta, delta or omicron variant, PRO-2000 displayed EC
Identifiants
pubmed: 37562608
pii: S0166-3542(23)00178-X
doi: 10.1016/j.antiviral.2023.105700
pii:
doi:
Substances chimiques
PRO 2000
0
Antiviral Agents
0
Angiotensin-Converting Enzyme 2
EC 3.4.17.23
Spike Glycoprotein, Coronavirus
0
spike protein, SARS-CoV-2
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
105700Informations de copyright
Copyright © 2023 The Authors. Published by Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.