Rate-dependent effects of state-specific sodium channel blockers in cardiac tissue: Insights from idealized models.
Cardiac action potential
Gate immobilization
Guarded receptor
Model reduction
State-specific drug-binding
Journal
Journal of theoretical biology
ISSN: 1095-8541
Titre abrégé: J Theor Biol
Pays: England
ID NLM: 0376342
Informations de publication
Date de publication:
21 09 2023
21 09 2023
Historique:
received:
07
12
2022
revised:
08
06
2023
accepted:
01
08
2023
medline:
13
9
2023
pubmed:
11
8
2023
entrez:
10
8
2023
Statut:
ppublish
Résumé
A common side effect of pharmaceutical drugs is an increased propensity for cardiac arrhythmias. Many drugs bind to cardiac ion-channels in a state-specific manner, which alters the ionic conductances in complicated ways, making it difficult to identify the mechanisms underlying pro-arrhythmic drug effects. To better understand the fundamental mechanisms underlying the diverse effects of state-dependent sodium (Na
Identifiants
pubmed: 37562674
pii: S0022-5193(23)00192-3
doi: 10.1016/j.jtbi.2023.111595
pii:
doi:
Substances chimiques
Ion Channels
0
Sodium Channel Blockers
0
Sodium Channels
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
111595Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL128537
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL126273
Pays : United States
Informations de copyright
Published by Elsevier Ltd.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.