HIV-1-induced nuclear invaginations mediated by VAP-A, ORP3, and Rab7 complex explain infection of activated T cells.


Journal

Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555

Informations de publication

Date de publication:
10 08 2023
Historique:
received: 27 05 2022
accepted: 19 07 2023
medline: 14 8 2023
pubmed: 11 8 2023
entrez: 10 8 2023
Statut: epublish

Résumé

The mechanism of human immunodeficiency virus 1 (HIV-1) nuclear entry, required for productive infection, is not fully understood. Here, we report that in HeLa cells and activated CD4

Identifiants

pubmed: 37563144
doi: 10.1038/s41467-023-40227-8
pii: 10.1038/s41467-023-40227-8
pmc: PMC10415338
doi:

Substances chimiques

Gene Products, env 0
Membrane Proteins 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

4588

Subventions

Organisme : NCI NIH HHS
ID : R15 CA252990
Pays : United States

Informations de copyright

© 2023. The Author(s).

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Auteurs

Mark F Santos (MF)

Touro University Nevada College of Osteopathic Medicine, Henderson, NV, USA.

Germana Rappa (G)

Touro University Nevada College of Osteopathic Medicine, Henderson, NV, USA.

Jana Karbanová (J)

Biotechnology Center (BIOTEC) and Center for Molecular and Cellular Bioengineering, Technische Universität Dresden, Dresden, Germany.

Patrizia Diana (P)

Department of Biological, Chemical, and Pharmaceutical Sciences and Technologies (STEBICEF), University of Palermo, Palermo, Italy.

Girolamo Cirrincione (G)

Department of Biological, Chemical, and Pharmaceutical Sciences and Technologies (STEBICEF), University of Palermo, Palermo, Italy.

Daniela Carbone (D)

Department of Biological, Chemical, and Pharmaceutical Sciences and Technologies (STEBICEF), University of Palermo, Palermo, Italy.

David Manna (D)

Touro College of Osteopathic Medicine, Middletown, New York, NY, USA.

Feryal Aalam (F)

Touro University Nevada College of Osteopathic Medicine, Henderson, NV, USA.

David Wang (D)

Touro University Nevada College of Osteopathic Medicine, Henderson, NV, USA.

Cheryl Vanier (C)

Touro University Nevada College of Osteopathic Medicine, Henderson, NV, USA.
Imgen Research, LLC, 5495 South Rainbow #201, Las Vegas, NV, USA.

Denis Corbeil (D)

Biotechnology Center (BIOTEC) and Center for Molecular and Cellular Bioengineering, Technische Universität Dresden, Dresden, Germany. denis.corbeil@tu-dresden.de.

Aurelio Lorico (A)

Touro University Nevada College of Osteopathic Medicine, Henderson, NV, USA. alorico@touro.edu.

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