Zonula Occludens Proteins Signaling in Inflammation and Tumorigenesis.

ZO protein inflammation signaling tight junction tumorigenesis

Journal

International journal of biological sciences

ISSN: 1449-2288

Titre abrégé: Int J Biol Sci

Pays: Australia

ID NLM: 101235568

Informations de publication

Date de publication:
2023

Historique:

received: 01 05 2023

accepted: 10 07 2023

medline: 11 8 2023

pubmed: 11 8 2023

entrez: 11 8 2023

Statut: epublish

Résumé

Tight junction (TJ) is the barrier of epithelial and endothelial cells to maintain paracellular substrate transport and cell polarity. As one of the TJ cytoplasmic adaptor proteins adjacent to cell membrane, zonula occludens (ZO) proteins are responsible for connecting transmembrane TJ proteins and cytoplasmic cytoskeleton, providing a binding platform for transmembrane TJ proteins to maintain the barrier function. In addition to the basic structural function, ZO proteins play important roles in signal regulation such as cell proliferation and motility, the latter including cell migration, invasion and metastasis, to influence embryonic development, tissue homeostasis, damage repair, inflammation, tumorigenesis, and cancer progression. In this review, we will focus on the signal regulating function of ZO proteins in inflammation and tumorigenesis, and discuss the limitations of previous research and future challenges in ZO protein research.

Identifiants

DOI: 10.7150/ijbs.85765 PMID: 37564207 PMC: PMC10411466

pubmed: 37564207

doi: 10.7150/ijbs.85765

pii: ijbsv19p3804

pmc: PMC10411466

doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

Pagination

3804-3815

Informations de copyright

Déclaration de conflit d'intérêts

Competing Interests: The authors have declared that no competing interest exists.

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