Transcriptomic profile of
B cells
MAIT cells
SARS-CoV-2
TNF
immune response
mRNA vaccine
single-cell RNA/TCR-sequencing
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2023
2023
Historique:
received:
19
04
2023
accepted:
28
06
2023
medline:
14
8
2023
pubmed:
11
8
2023
entrez:
11
8
2023
Statut:
epublish
Résumé
Higher frequencies of mucosal-associated invariant T (MAIT) cells were associated with an increased adaptive response to mRNA To investigate the effects of repeated SARS-CoV-2 vaccinations on the peripheral blood mononuclear cells (PBMCs), we performed a longitudinal single cell (sc)RNA-seq and scTCR-seq analysis of SARS-CoV-2 vaccinated healthy adults with two doses of the Pfizer-BioNTech We identified MAIT cells as an important source of TNF across circulating lymphocytes in response to repeated SARS-CoV-2 Overall, our results indicate that SARS-CoV-2
Identifiants
pubmed: 37564651
doi: 10.3389/fimmu.2023.1208662
pmc: PMC10410451
doi:
Substances chimiques
COVID-19 Vaccines
0
BNT162 Vaccine
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1208662Informations de copyright
Copyright © 2023 Marzano, Balin, Terzoli, Della Bella, Cazzetta, Piazza, Sandrock, Ravens, Tan, Prinz, Calcaterra, Di Vito, Cancellara, Calvi, Carletti, Franzese, Frigo, Darwish, Voza, Mikulak and Mavilio.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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