Questionnaire-based analysis of autism spectrum disorders and gastrointestinal symptoms in children and adolescents: a systematic review and meta-analysis.
autism spectrum disorder
children and adolescent
gastrointestinal
prevalence rate
questionnaire
Journal
Frontiers in pediatrics
ISSN: 2296-2360
Titre abrégé: Front Pediatr
Pays: Switzerland
ID NLM: 101615492
Informations de publication
Date de publication:
2023
2023
Historique:
received:
10
12
2022
accepted:
11
07
2023
medline:
11
8
2023
pubmed:
11
8
2023
entrez:
11
8
2023
Statut:
epublish
Résumé
Gastrointestinal (GI) symptoms are frequently experienced by children with autism spectrum disorder (ASD), and these symptoms cause difficulties for these children and their families. However, studies of GI symptom prevalence differ significantly. This meta-analysis aimed to analyze the prevalence of GI symptoms in children with ASD. PubMed, Scopus, Web of Science, EMBASE were electronically searched to collect all literature on gastrointestinal symptoms of children with ASD collected through questionnaires or scales from January 2012 to May 2021. Four researchers independently scanned the literature and extracted information on general characteristics. First author name, year of publication, geographical location, type of study, sample sizes of ASD and control (if any) children, sex and average age, number of GI cases, number of GI symptoms, GI assessment tools (gastrointestinal symptoms scale), autism diagnosis methods, and other necessary data were collected and analyzed using Stata V16. The questionnaires included the Rome, 6-GSI, GIQ, GSRS, GSIQ, ADI-R, PedsQL-GI, parent-report, GI-related, and self-administered questionnaires. Compared with typically developing (TD) children, the odds ratio for In children with ASD with at least one GI symptom was 3.64, and the total prevalence was 55%. The cumulative prevalence rates of various symptoms were summarized, showing that 37% of children with ASD had constipation, 21% had abdominal pain, 19% had diarrhea, 8% had vomiting, and 23% had abdominal distension. The results of this meta-analysis on GI symptoms in ASD show that patients with ASD are more likely to develop symptoms than TD children. The prevalence of GI symptoms in In children with ASD was 55%. www.crd.york.ac.uk/PROSPERO, identifier, #CRD42017080579.
Sections du résumé
Background
UNASSIGNED
Gastrointestinal (GI) symptoms are frequently experienced by children with autism spectrum disorder (ASD), and these symptoms cause difficulties for these children and their families. However, studies of GI symptom prevalence differ significantly. This meta-analysis aimed to analyze the prevalence of GI symptoms in children with ASD.
Methods and findings
UNASSIGNED
PubMed, Scopus, Web of Science, EMBASE were electronically searched to collect all literature on gastrointestinal symptoms of children with ASD collected through questionnaires or scales from January 2012 to May 2021. Four researchers independently scanned the literature and extracted information on general characteristics. First author name, year of publication, geographical location, type of study, sample sizes of ASD and control (if any) children, sex and average age, number of GI cases, number of GI symptoms, GI assessment tools (gastrointestinal symptoms scale), autism diagnosis methods, and other necessary data were collected and analyzed using Stata V16. The questionnaires included the Rome, 6-GSI, GIQ, GSRS, GSIQ, ADI-R, PedsQL-GI, parent-report, GI-related, and self-administered questionnaires. Compared with typically developing (TD) children, the odds ratio for In children with ASD with at least one GI symptom was 3.64, and the total prevalence was 55%. The cumulative prevalence rates of various symptoms were summarized, showing that 37% of children with ASD had constipation, 21% had abdominal pain, 19% had diarrhea, 8% had vomiting, and 23% had abdominal distension.
Conclusions
UNASSIGNED
The results of this meta-analysis on GI symptoms in ASD show that patients with ASD are more likely to develop symptoms than TD children. The prevalence of GI symptoms in In children with ASD was 55%.
Systematic Review Registration
UNASSIGNED
www.crd.york.ac.uk/PROSPERO, identifier, #CRD42017080579.
Identifiants
pubmed: 37565245
doi: 10.3389/fped.2023.1120728
pmc: PMC10410855
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
1120728Informations de copyright
© 2023 Gan, Su, Zhang, Huang, Lai, Lv and Li.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Front Cell Neurosci. 2019 Jul 16;13:320
pubmed: 31379506
J Child Psychol Psychiatry. 2018 Jul;59(7):717-720
pubmed: 29924395
Int Breastfeed J. 2006 Sep 15;1:16
pubmed: 16978397
Front Neurosci. 2020 Jan 23;13:1447
pubmed: 32038145
J Autism Dev Disord. 2022 Apr 20;:
pubmed: 35441914
Dig Liver Dis. 2016 Mar;48(3):248-54
pubmed: 26748423
Front Psychiatry. 2019 Apr 09;10:194
pubmed: 31024357
CMAJ. 2013 Mar 19;185(5):385-94
pubmed: 23401405
PLoS One. 2019 Jan 9;14(1):e0210064
pubmed: 30625189
Int J Environ Res Public Health. 2021 Jan 14;18(2):
pubmed: 33466802
Anaerobe. 2012 Apr;18(2):260-2
pubmed: 22202440
J Autism Dev Disord. 2001 Oct;31(5):505-11
pubmed: 11794415
Vopr Pitan. 2021;90(5):67-76
pubmed: 34719144
Autism Res. 2019 May;12(5):802-805
pubmed: 30964233
Curr Pediatr Rev. 2019;15(3):184-190
pubmed: 31264551
Front Psychiatry. 2021 Oct 27;12:744709
pubmed: 34777048
Nutr Neurosci. 2018 Nov;21(9):676-681
pubmed: 28686541
Neuropsychiatr Dis Treat. 2020 Jul 24;16:1807-1815
pubmed: 32801715
ANZ J Surg. 2003 Sep;73(9):712-6
pubmed: 12956787
Zhonghua Er Ke Za Zhi. 2017 Dec 2;55(12):905-910
pubmed: 29262469
Intellect Dev Disabil. 2022 Dec 1;60(6):484-503
pubmed: 36454617
PLoS One. 2015 Oct 01;10(10):e0137725
pubmed: 26427004
JAMA Netw Open. 2018 Jun 1;1(2):e180279
pubmed: 30646068
Eur J Pediatr. 2021 Apr;180(4):999-1008
pubmed: 33145704
Autism. 2021 Apr;25(3):705-718
pubmed: 32583679
J Dev Behav Pediatr. 2022 May 1;43(4):216-223
pubmed: 35170572
PLoS One. 2013 Jul 03;8(7):e68322
pubmed: 23844187
Autism Res. 2022 Jun;15(6):1142-1155
pubmed: 35302292
Microbiome. 2017 Jan 23;5(1):10
pubmed: 28122648
Autism Res. 2012 Apr;5(2):101-8
pubmed: 22511450
Epidemiology. 2015 Jul;26(4):451-7
pubmed: 25872161
MMWR Surveill Summ. 2021 Dec 03;70(10):1-14
pubmed: 34855727
Autism. 2018 Jul;22(5):625-635
pubmed: 28635306
Microorganisms. 2019 Jan 10;7(1):
pubmed: 30634578
Int J Eat Disord. 2021 Jun;54(6):981-985
pubmed: 33594728
Dev Neurorehabil. 2022 Jan;25(1):29-37
pubmed: 33934683
Nature. 2014 Jan 23;505(7484):559-63
pubmed: 24336217
JAMA Psychiatry. 2015 May;72(5):466-74
pubmed: 25806498
Front Psychiatry. 2019 Jul 25;10:528
pubmed: 31402878
J Mol Neurosci. 2021 Jan;71(1):153-161
pubmed: 32607756
J Autism Dev Disord. 2019 Jan;49(1):349-362
pubmed: 30350113
Nutrients. 2019 Dec 19;12(1):
pubmed: 31861722
Nutrients. 2019 Nov 18;11(11):
pubmed: 31752095
Autism. 2022 Oct;26(7):1698-1711
pubmed: 34903078
Autism Res. 2020 Oct;13(10):1778-1789
pubmed: 32767543
Disabil Health J. 2021 Jul;14(3):101052
pubmed: 33358227
Autism Res. 2018 Jan;11(1):24-36
pubmed: 28856868
Clin Transl Gastroenterol. 2015 Jun 18;6:e91
pubmed: 26087059
Front Psychiatry. 2020 Nov 05;11:493695
pubmed: 33240114
Pediatr Neurol. 2008 Dec;39(6):392-8
pubmed: 19027584
J Autism Dev Disord. 2021 Nov;51(11):3806-3817
pubmed: 33394243
Scand J Gastroenterol. 1995 Jan;30(1):50-3
pubmed: 7701250
Brain Behav Immun. 2021 Jul;95:122-141
pubmed: 33705867
Gastroenterol Clin North Am. 2017 Mar;46(1):49-60
pubmed: 28164852
Nutrients. 2016 May 14;8(5):
pubmed: 27187463
Pediatr Res. 2021 Jan;89(1):211-216
pubmed: 32225174
MMWR Surveill Summ. 2021 Dec 03;70(11):1-16
pubmed: 34855725
Autism Res. 2021 Oct;14(10):2131-2142
pubmed: 34114351
Expert Rev Gastroenterol Hepatol. 2021 Jun;15(6):599-622
pubmed: 33356668
J Autism Dev Disord. 2013 Sep;43(9):2159-73
pubmed: 23371510
Autism. 2021 Feb;25(2):405-415
pubmed: 32972215
Pediatrics. 2014 May;133(5):872-83
pubmed: 24777214
Autism Res. 2014 Aug;7(4):501-6
pubmed: 24753336
J Autism Dev Disord. 2017 Nov;47(11):3574-3588
pubmed: 28861653
J Autism Dev Disord. 2020 Apr;50(4):1401-1410
pubmed: 31955310
Nutrients. 2020 Mar 17;12(3):
pubmed: 32192218
Front Psychiatry. 2022 Mar 15;13:830234
pubmed: 35370829