Early Administration of the Phytocannabinoid Cannabidivarin Prevents the Neurobehavioral Abnormalities Associated with the
Fmr1
interleukins
mouse behavior
neurodevelopmental disorders
neurotrophins
phytocannabinoids
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
25 07 2023
25 07 2023
Historique:
received:
17
06
2023
revised:
14
07
2023
accepted:
18
07
2023
medline:
14
8
2023
pubmed:
11
8
2023
entrez:
11
8
2023
Statut:
epublish
Résumé
Phytocannabinoids, including the non-addictive cannabis component cannabidivarin (CBDV), have been reported to hold therapeutic potential in several neurodevelopmental disorders (NDDs). Nonetheless, the therapeutic value of phytocannabinoids for treating Fragile X syndrome (FXS), a major NDD, remains unexplored. Here, we characterized the neurobehavioral effects of CBDV at doses of 20 or 100 mg/kg in the
Identifiants
pubmed: 37566006
pii: cells12151927
doi: 10.3390/cells12151927
pmc: PMC10416983
pii:
doi:
Substances chimiques
cannabidivarin
I198VBV98I
Fragile X Mental Retardation Protein
139135-51-6
Fmr1 protein, mouse
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Références
Sci Rep. 2022 May 4;12(1):7269
pubmed: 35508566
J Autism Dev Disord. 2013 Jun;43(6):1452-8
pubmed: 23015112
Behav Brain Res. 2006 Mar 15;168(1):172-5
pubmed: 16343653
Autism Res. 2017 Jun;10(6):1067-1078
pubmed: 28301083
Int J Biochem Cell Biol. 2014 Aug;53:121-6
pubmed: 24831882
Neurobiol Dis. 2009 Nov;36(2):361-73
pubmed: 19666116
Exp Cell Res. 2000 Jul 10;258(1):162-70
pubmed: 10912798
Clin Chem. 2009 Apr;55(4):611-22
pubmed: 19246619
Dev Neurosci. 2011;33(5):395-403
pubmed: 22067669
Neuron. 2012 Apr 12;74(1):49-56
pubmed: 22500629
Psychoneuroendocrinology. 2006 Jul;31(6):781-5
pubmed: 16621323
Front Cell Neurosci. 2022 Oct 27;16:917183
pubmed: 36385949
J Neurosci. 2010 Jan 13;30(2):694-702
pubmed: 20071534
Neurosci Biobehav Rev. 2000 Jun;24(4):417-63
pubmed: 10817843
Psychoneuroendocrinology. 2014 Nov;49:119-29
pubmed: 25080404
Behav Brain Res. 2010 Mar 17;208(1):96-105
pubmed: 19932134
Nat Med. 2017 Jun;23(6):674-677
pubmed: 28504725
Dev Psychobiol. 1983 Mar;16(2):83-109
pubmed: 6339302
Genes Brain Behav. 2012 Apr;11(3):332-41
pubmed: 22268788
Neuropsychopharmacology. 2008 Oct;33(11):2667-75
pubmed: 18172434
Int J Neuropsychopharmacol. 2011 Jun;14(5):618-30
pubmed: 20497624
Science. 2007 May 25;316(5828):1212-6
pubmed: 17525344
Psychopharmacology (Berl). 2014 Aug;231(15):3009-17
pubmed: 24577515
J Cell Biol. 2003 Nov 10;163(3):463-8
pubmed: 14610053
Psychopharmacology (Berl). 2012 Feb;219(3):859-73
pubmed: 21796370
Neuroscience. 2011 Oct 27;194:282-90
pubmed: 21723920
Bioorg Med Chem. 2015 Apr 1;23(7):1377-85
pubmed: 25703248
Neuron. 2012 Oct 18;76(2):325-37
pubmed: 23083736
Behav Brain Res. 2017 Mar 1;320:128-135
pubmed: 27939692
Genes Brain Behav. 2005 Oct;4(7):420-30
pubmed: 16176388
J Neurosci. 1995 Mar;15(3 Pt 1):1768-77
pubmed: 7891134
Exp Neurol. 2010 Jul;224(1):3-14
pubmed: 20353783
Cell. 1991 Aug 23;66(4):817-22
pubmed: 1878973
J Neurodev Disord. 2017 Jun 12;9:6
pubmed: 28616095
Oncotarget. 2014 Aug 15;5(15):5852-72
pubmed: 25115386
Vitam Horm. 2010;82:185-200
pubmed: 20472139
Prog Chem Org Nat Prod. 2017;103:103-131
pubmed: 28120232
Pharmacotherapy. 2016 Jul;36(7):781-96
pubmed: 27285147
Neurotherapeutics. 2015 Oct;12(4):825-36
pubmed: 26341731
J Neurochem. 2008 Aug;106(3):1378-87
pubmed: 18485098
Physiol Rev. 2009 Jan;89(1):309-80
pubmed: 19126760
Behav Brain Res. 2012 Mar 1;228(1):1-8
pubmed: 22123412
Behav Brain Res. 2012 Apr 1;229(1):244-9
pubmed: 22285772
J Mol Neurosci. 2000 Oct;15(2):99-108
pubmed: 11220789
PLoS One. 2010 Mar 16;5(3):e9706
pubmed: 20300527
Neuroscience. 2013 Jun 3;239:196-213
pubmed: 22967840
Proc Natl Acad Sci U S A. 2007 Jul 3;104(27):11489-94
pubmed: 17592139
Neurobiol Aging. 2013 Jun;34(6):1599-609
pubmed: 23352115
Behav Brain Res. 1996 Jun;78(1):25-36
pubmed: 8793034
Pharmacol Biochem Behav. 2006 Dec;85(4):842-9
pubmed: 17204313
Neurosci Biobehav Rev. 2022 Aug;139:104722
pubmed: 35690123
Hum Mol Genet. 2000 May 1;9(8):1145-59
pubmed: 10767339
Trends Neurosci. 2004 Jul;27(7):370-7
pubmed: 15219735
Anim Behav. 2000 Nov;60(5):689-694
pubmed: 11082239
Elife. 2022 Oct 11;11:
pubmed: 36217821
Stress. 2000 May;3(3):201-8
pubmed: 10938581
Neuropharmacology. 2018 Sep 15;140:121-129
pubmed: 30056123
Front Cell Neurosci. 2019 Aug 09;13:367
pubmed: 31447649
J Neurosci. 2007 Dec 19;27(51):13958-67
pubmed: 18094233
Hippocampus. 2002;12(1):39-46
pubmed: 11918286
Brain Res. 2002 Feb 8;927(1):8-17
pubmed: 11814427
Behav Genet. 2009 Nov;39(6):623-31
pubmed: 19641985
Biochem Cell Biol. 1999;77(4):331-42
pubmed: 10546896
Autism Res. 2017 Oct;10(10):1584-1596
pubmed: 28590057
Psychoneuroendocrinology. 2007 Sep-Nov;32(8-10):1106-15
pubmed: 17976923
Nat Neurosci. 2009 Sep;12(9):1152-8
pubmed: 19648913
Neuron. 2006 Aug 17;51(4):455-66
pubmed: 16908411
Brain Res. 2012 Feb 23;1439:7-14
pubmed: 22265702
Nat Neurosci. 2014 Dec;17(12):1701-9
pubmed: 25383903
Neuropsychopharmacology. 2015 Mar 13;40(5):1113-22
pubmed: 25348604
Nat Rev Neurosci. 2008 Jan;9(1):46-56
pubmed: 18073775
Ann N Y Acad Sci. 2004 Jun;1021:23-6
pubmed: 15251870
Br J Pharmacol. 2012 Dec;167(8):1629-42
pubmed: 22970845
Behav Brain Res. 2019 Oct 17;372:112068
pubmed: 31271818
Cell. 1994 Jul 15;78(1):23-33
pubmed: 8033209
Pharmacol Ther. 2012 Jan;133(1):79-97
pubmed: 21924288
Neuropsychopharmacology. 2010 Jun;35(7):1500-9
pubmed: 20393458
Philos Trans R Soc Lond B Biol Sci. 2012 Dec 5;367(1607):3254-63
pubmed: 23108544
Pharmacol Res. 2016 Oct;112:119-127
pubmed: 26845349
Proc Natl Acad Sci U S A. 2005 Aug 9;102(32):11557-62
pubmed: 16076950
Methods. 2001 Dec;25(4):402-8
pubmed: 11846609
Handb Exp Pharmacol. 2005;(168):299-325
pubmed: 16596779
Pharmacol Rep. 2013;65(3):535-46
pubmed: 23950576
Biol Psychiatry. 2014 Feb 1;75(3):189-97
pubmed: 23910948
Orphanet J Rare Dis. 2014 Aug 01;9:124
pubmed: 25079250
Neuropsychopharmacology. 2009 Mar;34(4):1011-26
pubmed: 18843266
J Psychopharmacol. 2019 Jul;33(7):894-907
pubmed: 31084246
Genes Brain Behav. 2012 Jul;11(5):513-23
pubmed: 22435671
PLoS One. 2011 Feb 22;6(2):e17073
pubmed: 21364941
J Neurosci. 2010 Apr 21;30(16):5724-9
pubmed: 20410124
Autism Res. 2011 Feb;4(1):40-56
pubmed: 21268289
Front Neurosci. 2022 Jul 08;16:968115
pubmed: 35879927
Behav Pharmacol. 2004 Sep;15(5-6):433-42
pubmed: 15343070
Front Mol Neurosci. 2015 Nov 16;8:68
pubmed: 26635521
Cell. 1991 May 31;65(5):905-14
pubmed: 1710175
Mini Rev Med Chem. 2009 Apr;9(4):448-62
pubmed: 19356123
Nat Commun. 2012;3:1080
pubmed: 23011134
J Neurosci. 2001 Dec 15;21(24):RC188
pubmed: 11734603
Nat Med. 2013 May;19(5):603-7
pubmed: 23542787
Behav Brain Res. 2011 Oct 1;223(2):310-21
pubmed: 21571007