Genetic Downregulation of the Metabotropic Glutamate Receptor Type 5 Dampens the Reactive and Neurotoxic Phenotype of Adult ALS Astrocytes.
Grm5 genetic ablation
SOD1G93A mice
adult mouse spinal cord astrocytes
amyotrophic lateral sclerosis
mGlu5 receptor
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
27 07 2023
27 07 2023
Historique:
received:
01
06
2023
revised:
24
07
2023
accepted:
25
07
2023
medline:
14
8
2023
pubmed:
11
8
2023
entrez:
11
8
2023
Statut:
epublish
Résumé
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by progressive degeneration of motor neurons (MNs). Astrocytes display a toxic phenotype in ALS, which results in MN damage. Glutamate (Glu)-mediated excitotoxicity and group I metabotropic glutamate receptors (mGluRs) play a pathological role in the disease progression. We previously demonstrated that in vivo genetic ablation or pharmacological modulation of mGluR5 reduced astrocyte activation and MN death, prolonged survival and ameliorated the clinical progression in the SOD1
Identifiants
pubmed: 37566031
pii: cells12151952
doi: 10.3390/cells12151952
pmc: PMC10416852
pii:
doi:
Substances chimiques
Glutamic Acid
3KX376GY7L
Superoxide Dismutase-1
EC 1.15.1.1
Grm5 protein, mouse
0
Receptor, Metabotropic Glutamate 5
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Références
Cell Signal. 2014 Oct;26(10):2284-97
pubmed: 24793301
Biochim Biophys Acta. 2006 Nov-Dec;1762(11-12):1068-82
pubmed: 16806844
Neurosci Lett. 1999 Feb 12;261(1-2):25-8
pubmed: 10081918
Neuropsychopharmacology. 2018 Feb;43(3):503-512
pubmed: 28816242
Neuron Glia Biol. 2008 Feb;4(1):35-42
pubmed: 19267952
Cell Rep. 2016 May 31;15(9):1859-65
pubmed: 27210751
Ann Neurol. 2004 Apr;55(4):469-77
pubmed: 15048885
Brain Res. 1998 Oct 5;807(1-2):1-10
pubmed: 9756982
J Cell Biol. 1996 Aug;134(4):971-83
pubmed: 8769421
J Neuroinflammation. 2012 Mar 15;9:52
pubmed: 22420994
Neurobiol Dis. 2016 Nov;95:122-33
pubmed: 27425885
Glia. 2016 Jun;64(6):1050-65
pubmed: 27014856
Muscle Nerve. 2009 Aug;40(2):297-304
pubmed: 19609920
Biochim Biophys Acta Mol Basis Dis. 2017 Jun;1863(6):1214-1221
pubmed: 28315453
Mol Neurobiol. 2018 Dec;55(12):9220-9233
pubmed: 29656361
Hum Mol Genet. 2014 Apr 15;23(8):2030-42
pubmed: 24282028
Proc Natl Acad Sci U S A. 2005 Nov 8;102(45):16448-53
pubmed: 16260743
Genome Res. 2022 Jan;32(1):71-84
pubmed: 34963663
Neurotherapeutics. 2022 Jul;19(4):1248-1258
pubmed: 35585374
Nat Rev Neurol. 2023 Jul;19(7):395-409
pubmed: 37308616
Mol Neurobiol. 2020 Mar;57(3):1418-1431
pubmed: 31754998
Cells. 2019 Feb 20;8(2):
pubmed: 30791579
Eur J Neurosci. 2003 May;17(10):2106-18
pubmed: 12786977
Trends Immunol. 2007 Mar;28(3):138-45
pubmed: 17276138
Neuropharmacology. 2011 Jun;60(7-8):1017-41
pubmed: 21036182
Mol Med. 2012 Jul 18;18:794-804
pubmed: 22481270
Anal Biochem. 1976 May 7;72:248-54
pubmed: 942051
Glia. 2018 Apr;66(4):749-761
pubmed: 29266405
Glia. 2018 May;66(5):1016-1033
pubmed: 29380416
Lancet Neurol. 2019 Feb;18(2):211-220
pubmed: 30663610
Sci Signal. 2017 Dec 19;10(510):
pubmed: 29259100
Cold Spring Harb Protoc. 2014 May 01;2014(5):
pubmed: 24786509
Eur J Clin Invest. 2020 May;50(5):e13228
pubmed: 32293029
Science. 1994 Jun 17;264(5166):1772-5
pubmed: 8209258
Proc Natl Acad Sci U S A. 2010 Jul 20;107(29):13046-50
pubmed: 20616033
J Neurol. 1997 May;244 Suppl 2:S3-14
pubmed: 9178165
Br J Pharmacol. 2003 Mar;138(6):1021-5
pubmed: 12684256
PLoS One. 2017 Jun 12;12(6):e0179383
pubmed: 28604836
Biochim Biophys Acta. 2005 Jan 7;1706(1-2):1-11
pubmed: 15620362
J Neurosci. 2014 Feb 5;34(6):2331-48
pubmed: 24501372
Ann Neurol. 1995 Jul;38(1):73-84
pubmed: 7611729
Mov Disord. 2016 Sep;31(9):1373-80
pubmed: 27214664
Mol Brain. 2013 Feb 14;6:9
pubmed: 23406666
Neuropharmacology. 2017 Mar 15;115:180-192
pubmed: 27140693
N Engl J Med. 2001 May 31;344(22):1688-700
pubmed: 11386269
Nat Neurosci. 2007 May;10(5):608-14
pubmed: 17435754
Acta Neuropathol. 2017 Jun;133(6):863-885
pubmed: 28409282
Nat Protoc. 2010 Jan;5(1):31-8
pubmed: 20057379
Trends Mol Med. 2004 Aug;10(8):393-400
pubmed: 15310460
J Neurosci. 1997 Jul 1;17(13):5196-205
pubmed: 9185557
Cells. 2022 Dec 04;11(23):
pubmed: 36497181
J Neurol Neurosurg Psychiatry. 2014 May;85(5):478-85
pubmed: 23833266
J Pers Med. 2020 Aug 25;10(3):
pubmed: 32854276
Neuroreport. 2004 Feb 9;15(2):271-3
pubmed: 15076751
Neurosci Lett. 2019 Jan 10;689:1-4
pubmed: 30031035
Front Neurosci. 2017 Jan 10;10:611
pubmed: 28119559
Front Cell Neurosci. 2020 Apr 24;14:90
pubmed: 32390802
Mov Disord. 2016 Jul;31(7):1054-8
pubmed: 27214258
Cell. 1995 Mar 10;80(5):687-92
pubmed: 7889564
J Physiol. 2008 Mar 15;586(6):1503-8
pubmed: 18202092
Biophys J. 2004 Jun;86(6):3993-4003
pubmed: 15189895
Trends Neurosci. 2021 Aug;44(8):658-668
pubmed: 34006386
Cell Cycle. 2014;13(9):1400-12
pubmed: 24626186
Cold Spring Harb Perspect Med. 2017 Aug 1;7(8):
pubmed: 28003278
Eur J Neurosci. 2000 Jul;12(7):2333-44
pubmed: 10947812
Brain Res Brain Res Rev. 1999 Jan;29(1):121-35
pubmed: 9974153
Free Radic Biol Med. 2000 Aug;29(3-4):222-30
pubmed: 11035250
Mediators Inflamm. 2017;2017:1626204
pubmed: 28713206
Nucleic Acid Ther. 2017 Feb;27(1):1-3
pubmed: 27929755
J Biol Chem. 1985 Mar 25;260(6):3440-50
pubmed: 3838314
Mol Neurobiol. 2018 Mar;55(3):2350-2361
pubmed: 28357805
Science. 2007 Apr 20;316(5823):353
pubmed: 17446359
Nat Rev Immunol. 2009 Jun;9(6):429-39
pubmed: 19461673
J Neurochem. 2011 Mar;116(6):1028-42
pubmed: 21175617
J Pharmacol Exp Ther. 2015 Apr;353(1):213-33
pubmed: 25665805
Mol Genet Metab. 2012 Mar;105(3):472-8
pubmed: 22264771
Antioxidants (Basel). 2021 Aug 30;10(9):
pubmed: 34573024
BMC Neurosci. 2013 Jul 29;14:75
pubmed: 23895555
Int J Mol Sci. 2021 Nov 12;22(22):
pubmed: 34830115
J Cell Biol. 2009 Dec 14;187(6):761-72
pubmed: 19951898
Cell Metab. 2011 Dec 7;14(6):724-38
pubmed: 22152301
JAMA Psychiatry. 2016 Jul 1;73(7):675-84
pubmed: 27304433
J Neurol Sci. 2002 Jan 15;193(2):73-8
pubmed: 11790386
Mol Biol Rep. 2023 Aug;50(8):6611-6617
pubmed: 37344642
Neurochem Res. 2008 Dec;33(12):2436-43
pubmed: 18438710
Nat Med. 2022 Jan;28(1):104-116
pubmed: 35075293
J Clin Neurosci. 2016 Apr;26:75-8
pubmed: 26602604
Nucleic Acids Res. 2007;35(2):687-700
pubmed: 17182632
J Pharmacol Exp Ther. 2011 Nov;339(2):474-86
pubmed: 21849627
J Neurol Sci. 2006 Aug 15;247(1):1-9
pubmed: 16697014
Stem Cell Reports. 2017 Aug 8;9(2):667-680
pubmed: 28712846
J Anat. 2007 Jun;210(6):651-60
pubmed: 17504269
Neuron. 2006 Oct 5;52(1):39-59
pubmed: 17015226
Oncotarget. 2015 May 20;6(14):11806-19
pubmed: 25909219
Expert Rev Neurother. 2020 Mar;20(3):281-293
pubmed: 32031423
Neuroreport. 2006 Dec 18;17(18):1877-81
pubmed: 17179862
Exp Neurol. 2009 Feb;215(2):368-79
pubmed: 19071115
Nat Rev Neurol. 2011 Nov;7(11):616-30
pubmed: 22051914
Exp Neurol. 2016 Jan;275 Pt 1:162-71
pubmed: 26584004
Cells. 2022 Mar 28;11(7):
pubmed: 35406702
Arch Biochem Biophys. 2014 Nov 15;562:1-8
pubmed: 25151305
Biology (Basel). 2022 Aug 08;11(8):
pubmed: 36009818
Nat Neurosci. 2017 Apr;20(4):497-499
pubmed: 28192393
Exp Neurol. 2014 Dec;262 Pt B:111-20
pubmed: 24859452
J Neuropathol Exp Neurol. 2004 Aug;63(8):831-40
pubmed: 15330338
Methods. 2001 Dec;25(4):402-8
pubmed: 11846609
Int J Mol Sci. 2019 Sep 13;20(18):
pubmed: 31540330
Proc Natl Acad Sci U S A. 2011 Nov 1;108(44):18126-31
pubmed: 22010221
J Cell Physiol. 2018 Feb;233(2):1736-1751
pubmed: 28681917
Hum Mol Genet. 2012 Feb 15;21(4):826-40
pubmed: 22072391
Cell Death Differ. 2008 Nov;15(11):1691-700
pubmed: 18617894
Acta Neuropathol. 2018 Apr;135(4):489-509
pubmed: 29549424
Neurobiol Dis. 2015 Feb;74:314-24
pubmed: 25497732
Br J Pharmacol. 2021 Sep;178(18):3747-3764
pubmed: 33931856
Neurosci Lett. 2009 Dec 25;467(2):127-30
pubmed: 19822193
Ann Neurol. 2009 Jul;66(1):75-80
pubmed: 19670443
J Neurochem. 2005 Jul;94(2):405-16
pubmed: 15998291
Curr Neuropharmacol. 2016;14(4):314-21
pubmed: 26786249
J Neuroinflammation. 2015 Nov 24;12:217
pubmed: 26597638
J Biol Chem. 2010 Jan 1;285(1):631-43
pubmed: 19880516
J Neurosci. 2017 Apr 19;37(16):4231-4242
pubmed: 28314814
N Engl J Med. 2022 Sep 22;387(12):1099-1110
pubmed: 36129998
Cereb Cortex. 2013 Sep;23(9):2179-89
pubmed: 22791805
Neuropathology. 2020 Dec;40(6):587-598
pubmed: 33305472
Lancet Neurol. 2017 Jul;16(7):505-512
pubmed: 28522181
Mov Disord. 2015 Mar;30(3):427-31
pubmed: 25689146
Neuropharmacology. 2017 Sep 1;123:433-445
pubmed: 28645622
J Neurochem. 2006 Oct;99(2):641-56
pubmed: 16836654
Neuron. 2015 May 20;86(4):883-901
pubmed: 25996133
J Neurol Sci. 1996 Aug;139 Suppl:27-33
pubmed: 8899654
Br J Pharmacol. 2020 Aug;177(16):3617-3624
pubmed: 32662519
Cell. 2011 Sep 2;146(5):785-98
pubmed: 21855979
Neuroscience. 2001;105(2):509-20
pubmed: 11672616
Neurobiol Dis. 2019 Sep;129:79-92
pubmed: 31102766
Nat Neurosci. 2008 Mar;11(3):251-3
pubmed: 18246065
J Physiol. 2021 Sep;599(17):4065-4084
pubmed: 34174096
Prog Neurobiol. 2001 Sep;65(1):1-105
pubmed: 11369436
J Biomed Res. 2022 Aug 28;36(5):336-342
pubmed: 36106501
J Med Chem. 2015 Feb 12;58(3):1358-71
pubmed: 25565255
Nat Rev Neurol. 2014 Nov;10(11):661-70
pubmed: 25311585
J Microsc. 1993 Mar;169(3):375-382
pubmed: 33930978