The context-dependent role of the Na
Ca2+
Metastasis
Migration
Na+/Ca2+-exchanger (NCX)
Pancreatic stellate cells (PSCs)
Tumor microenvironment (TME)
Journal
Pflugers Archiv : European journal of physiology
ISSN: 1432-2013
Titre abrégé: Pflugers Arch
Pays: Germany
ID NLM: 0154720
Informations de publication
Date de publication:
10 2023
10 2023
Historique:
received:
16
06
2023
accepted:
26
07
2023
revised:
16
06
2023
medline:
14
9
2023
pubmed:
11
8
2023
entrez:
11
8
2023
Statut:
ppublish
Résumé
Pancreatic stellate cells (PSCs) that can co-metastasize with cancer cells shape the tumor microenvironment (TME) in pancreatic ductal adenocarcinoma (PDAC) by producing an excessive amount of extracellular matrix. This leads to a TME characterized by increased tissue pressure, hypoxia, and acidity. Moreover, cells within the tumor secrete growth factors. The stimuli of the TME trigger Ca
Identifiants
pubmed: 37566113
doi: 10.1007/s00424-023-02847-3
pii: 10.1007/s00424-023-02847-3
pmc: PMC10499968
doi:
Substances chimiques
Sodium-Calcium Exchanger
0
Membrane Transport Proteins
0
Calcium
SY7Q814VUP
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1225-1240Commentaires et corrections
Type : ErratumIn
Informations de copyright
© 2023. The Author(s).
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