Pleural mesothelioma risk in the construction industry: a case-control study in Italy, 2000-2018.
case-control studies
epidemiology
occupational & industrial medicine
public health
respiratory tract tumours
Journal
BMJ open
ISSN: 2044-6055
Titre abrégé: BMJ Open
Pays: England
ID NLM: 101552874
Informations de publication
Date de publication:
11 08 2023
11 08 2023
Historique:
medline:
14
8
2023
pubmed:
12
8
2023
entrez:
11
8
2023
Statut:
epublish
Résumé
Workers in the construction industry have been exposed to asbestos in various occupations. In Italy, a National Mesothelioma Registry has been implemented more than 20 years ago. Using cases selected from this registry and exploiting existing control data sets, we estimated relative risks for pleural mesothelioma (PM) among construction workers. Case-control study. Cases from the National Mesothelioma Registry (2000-2018), controls from three previous case-control studies. We selected male PM incident cases diagnosed in 2000-2018. Population controls were taken from three studies performed in six Italian regions within two periods (2002-2004 and 2012-2016). Age-adjusted and period-adjusted unconditional logistic regression models were fitted to estimate odds ratios (OR) for occupations in the construction industry. We followed two approaches, one (primary) excluding and the other (secondary) including subjects employed in other non-construction blue collar occupations for >5 years. For both approaches, we performed an overall analysis including all cases and, given the incomplete temporal and geographic overlap of cases and controls, three time or/and space restricted sensitivity analyses. The whole data set included 15 592 cases and 2210 controls. With the primary approach (4797 cases and 1085 controls), OR was 3.64 (2181 cases) for subjects ever employed in construction. We found elevated risks for blue-collar occupations (1993 cases, OR 4.52), including bricklayers (988 cases, OR 7.05), general construction workers (320 cases, OR 4.66), plumbers and pipe fitters (305 cases, OR 9.13), painters (104 cases, OR 2.17) and several others. Sensitivity analyses yielded very similar findings. Using the secondary approach, we observed similar patterns, but ORs were remarkably lower. We found markedly increased PM risks for most occupations in the construction industry. These findings are relevant for compensation of subjects affected with mesothelioma in the construction industry.
Identifiants
pubmed: 37567753
pii: bmjopen-2023-073480
doi: 10.1136/bmjopen-2023-073480
pmc: PMC10423786
doi:
Substances chimiques
Asbestos
1332-21-4
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e073480Investigateurs
D Di Marzio
(D)
L Richiardi
(L)
M Gangemi
(M)
C Brentisci
(C)
M Gilardetti
(M)
D Mirabelli
(D)
M Bonzini
(M)
B Dallari
(B)
A C Pesatori
(AC)
S Rugarli
(S)
U Fedeli
(U)
P De Michieli
(P)
L Mangone
(L)
C Storchi
(C)
O Sala
(O)
V Cacciarini
(V)
L Giovannetti
(L)
A Martini
(A)
Elisabetta Chellini
(E)
C Pascucci
(C)
P Michelozzi
(P)
M Davoli
(M)
L Ancona
(L)
A Balestri
(A)
G Serio
(G)
L De Maria
(L)
A Caputi
(A)
M C Delfino
(MC)
F Pentimone
(F)
S G Lio
(SG)
G Frasca
(G)
M C Giurdanella
(MC)
C Martorana
(C)
P Rollo
(P)
E Spata
(E)
G Dardanoni
(G)
S Scondotto
(S)
M R Angius
(MR)
S Stecchi
(S)
Informations de copyright
© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: DCo, SMa and CM served as consultants in trials concerning asbestos-related diseases.
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