Clostridioides difficile infection in thoroughbred horses in Japan from 2010 to 2021.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
11 08 2023
11 08 2023
Historique:
received:
10
02
2023
accepted:
05
08
2023
medline:
14
8
2023
pubmed:
12
8
2023
entrez:
11
8
2023
Statut:
epublish
Résumé
We encountered 34 Clostridioides difficile (C. difficile) infection (CDI) cases among Thoroughbred horses in Japan from 2010 to 2021. Among them, 79.4% (27/34) either died or were euthanised. The risk factors associated with CDI and mortality among Japanese Thoroughbred horses remain unclear. We used genetic methods to examine C. difficile strains and their relationships with prognosis. Twenty-two (64.7%) cases were hospitalised at the onset of colitis. Outcomes were balanced for hospitalisation rates at the onset of colitis. The mortality rates of cases treated with metronidazole (65.0%) were significantly lower than untreated cases (100%). The predominant genotype of C. difficile isolate was polymerase chain reaction ribotype (RT) 078, isolated from 12 cases (35.3%), followed by RT014 (six cases, 17.6%). Binary toxin (C. difficile transferase [CDT])-positive strains, including all RT078 strains, were isolated from 16 horses. Mortality rates in RT078 strain (75.0%) or CDT-positive strain (83.3%) cases were comparable to that in cases of other types. Sufficient infection control is needed to prevent CDI in Thoroughbred horses. A timely and prompt CDI diagnosis leading to metronidazole treatment would improve CDI outcomes.
Identifiants
pubmed: 37567893
doi: 10.1038/s41598-023-40157-x
pii: 10.1038/s41598-023-40157-x
pmc: PMC10421859
doi:
Substances chimiques
Metronidazole
140QMO216E
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
13099Informations de copyright
© 2023. Springer Nature Limited.
Références
FEMS Microbiol Lett. 1999 Jun 15;175(2):197-203
pubmed: 10386368
J Clin Microbiol. 2008 Feb;46(2):431-7
pubmed: 18039796
J Clin Microbiol. 1998 Aug;36(8):2178-82
pubmed: 9665986
J Clin Microbiol. 1999 Feb;37(2):461-3
pubmed: 9889244
Vet Microbiol. 2007 Feb 25;120(1-2):179-83
pubmed: 17112686
Lancet Infect Dis. 2010 Jun;10(6):395-404
pubmed: 20510280
J Clin Microbiol. 2017 Mar;55(3):865-876
pubmed: 28031436
Vet Microbiol. 2013 Nov 29;167(1-2):42-9
pubmed: 23642413
Equine Vet J. 1997 Jul;29(4):279-84
pubmed: 15338908
J Appl Microbiol. 2009 Oct;107(4):1367-74
pubmed: 19426274
Anaerobe. 2019 Apr;56:17-21
pubmed: 30630037
J Clin Microbiol. 2007 Jun;45(6):1963-4
pubmed: 17428945
Anaerobe. 2020 Feb;61:102136
pubmed: 31857201
Vet Rec. 2013 Dec 21;173(24):607
pubmed: 24336792
J Vet Diagn Invest. 2020 Mar;32(2):213-221
pubmed: 31904312
Vet Rec. 2020 Jul 25;187(2):e14
pubmed: 32201380
Front Microbiol. 2017 Jan 11;7:2138
pubmed: 28123380
Equine Vet J. 2006 Mar;38(2):185-8
pubmed: 16536390
J Clin Microbiol. 2008 Mar;46(3):1157; author reply 1158
pubmed: 18326836
J Clin Microbiol. 2008 Nov;46(11):3703-13
pubmed: 18832125
Equine Vet J. 2003 Jul;35(5):465-71
pubmed: 12875324
FEMS Microbiol Lett. 2000 May 15;186(2):307-12
pubmed: 10802189
Animals (Basel). 2022 May 07;12(9):
pubmed: 35565629
J Med Microbiol. 2010 May;59(Pt 5):556-562
pubmed: 20133413
Vet Microbiol. 2011 Aug 26;152(1-2):212-5
pubmed: 21570780
J Vet Diagn Invest. 2022 May;34(3):412-420
pubmed: 34455808
Vet Clin North Am Equine Pract. 2004 Dec;20(3):615-30
pubmed: 15519822
J Clin Med. 2016 Sep 21;5(9):
pubmed: 27657145
Eur J Clin Microbiol Infect Dis. 2019 Jul;38(7):1211-1221
pubmed: 30945014
J Hosp Infect. 2012 Mar;80(3):229-37
pubmed: 22306443
Clin Microbiol Infect. 2014 May;20(5):396-404
pubmed: 24621128
Clin Microbiol Rev. 2005 Apr;18(2):247-63
pubmed: 15831824
Anaerobe. 2022 Apr;74:102510
pubmed: 34990814
BMC Vet Res. 2012 Jun 29;8:94
pubmed: 22748233
J Vet Diagn Invest. 2009 May;21(3):377-80
pubmed: 19407094