The Urinary Concentration of Trefoil Factor 3 (TFF3) in the Term and Preterm Neonates.
Trefoil factor 3
biomarkers
kidney
kidney disease
neonates
Journal
Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588
Informations de publication
Date de publication:
27 Jul 2023
27 Jul 2023
Historique:
received:
29
05
2023
revised:
19
07
2023
accepted:
20
07
2023
medline:
12
8
2023
pubmed:
12
8
2023
entrez:
12
8
2023
Statut:
epublish
Résumé
Distinguishing between a pathologic state and renal development is important in neonatology. Because the assessment of serum creatinine in neonates is not reliable, better biomarkers are needed. Trefoil factor 3 (TFF3) is proposed as a biomarker of kidney injury. The study aimed to assess its urinary concentration in healthy term and stable preterm neonates. The study included 80 term and 20 preterm neonates born in the Department of Perinatology of the University Clinical Hospital in Bialystok. Urine was obtained from the term neonates on the 1st day of life and from the preterm neonates on the 1st, 8th, 15th and 22nd day of life. The urinary concentration of TFF3 was determined using a commercially available immunoassay and was normalized for the urinary creatinine concentration (cr.). The values of TFF3/cr. were higher in the preterm than in the term neonates ( Prematurity is associated with higher urinary excretion of TFF3. Male gender is associated with an increased urinary TFF3 excretion in term neonates.
Sections du résumé
BACKGROUND
BACKGROUND
Distinguishing between a pathologic state and renal development is important in neonatology. Because the assessment of serum creatinine in neonates is not reliable, better biomarkers are needed. Trefoil factor 3 (TFF3) is proposed as a biomarker of kidney injury. The study aimed to assess its urinary concentration in healthy term and stable preterm neonates.
MATERIAL AND METHODS
METHODS
The study included 80 term and 20 preterm neonates born in the Department of Perinatology of the University Clinical Hospital in Bialystok. Urine was obtained from the term neonates on the 1st day of life and from the preterm neonates on the 1st, 8th, 15th and 22nd day of life. The urinary concentration of TFF3 was determined using a commercially available immunoassay and was normalized for the urinary creatinine concentration (cr.).
RESULTS
RESULTS
The values of TFF3/cr. were higher in the preterm than in the term neonates (
CONCLUSIONS
CONCLUSIONS
Prematurity is associated with higher urinary excretion of TFF3. Male gender is associated with an increased urinary TFF3 excretion in term neonates.
Identifiants
pubmed: 37568337
pii: jcm12154936
doi: 10.3390/jcm12154936
pmc: PMC10419516
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Medical University of Bialystok
ID : B.SUB.23.254
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