Mutational Profile Enables the Identification of a High-Risk Subgroup in Myelodysplastic Syndromes with Isolated Trisomy 8.
AML progression
NGS
isolated trisomy 8
myelodysplastic syndromes
prognostic stratification
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
27 Jul 2023
27 Jul 2023
Historique:
received:
05
06
2023
revised:
20
07
2023
accepted:
23
07
2023
medline:
12
8
2023
pubmed:
12
8
2023
entrez:
12
8
2023
Statut:
epublish
Résumé
Trisomy 8 (+8) is the most frequent trisomy in myelodysplastic syndromes (MDS) and is associated with clinical heterogeneity and intermediate cytogenetic risk when found in isolation. The presence of gene mutations in this group of patients and the prognostic significance has not been extensively analyzed. Targeted deep sequencing was performed in a cohort of 79 MDS patients showing isolated +8. The most frequently mutated genes were:
Identifiants
pubmed: 37568638
pii: cancers15153822
doi: 10.3390/cancers15153822
pmc: PMC10417840
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Junta de Castilla y León
ID : GRS 2341/A/21
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