Influence of the Hypersensitivity to Low Dose Phenomenon on the Tumor Response to Hypofractionated Stereotactic Body Radiation Therapy.
HRS phenomenon
LDRT
SBRT
cancer
low-dose
radiation therapy
radiosensitivity
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
05 Aug 2023
05 Aug 2023
Historique:
received:
04
07
2023
revised:
30
07
2023
accepted:
03
08
2023
medline:
12
8
2023
pubmed:
12
8
2023
entrez:
12
8
2023
Statut:
epublish
Résumé
Stereotactic body radiation therapy (SBRT) has made the hypofractionation of high doses delivered in a few sessions more acceptable. While the benefits of hypofractionated SBRT have been attributed to additional vascular, immune effects, or specific cell deaths, a radiobiological and mechanistic model is still needed. By considering each session of SBRT, the dose is divided into hundreds of minibeams delivering some fractions of Gy. In such a dose range, the hypersensitivity to low dose (HRS) phenomenon can occur. HRS produces a biological effect equivalent to that produced by a dose 5-to-10 times higher. To examine whether HRS could contribute to enhancing radiation effects under SBRT conditions, we exposed tumor cells of different HRS statuses to SBRT. Four human HRS-positive and two HRS-negative tumor cell lines were exposed to different dose delivery modes: a single dose of 0.2 Gy, 2 Gy, 10 × 0.2 Gy, and a single dose of 2 Gy using a non-coplanar isocentric minibeams irradiation mode were delivered. Anti-
Identifiants
pubmed: 37568795
pii: cancers15153979
doi: 10.3390/cancers15153979
pmc: PMC10416967
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Commissariat Général à l'Investissement
ID : INDIRA Project
Organisme : Centre National d'Études Spatiales
ID : ATHENA and BERNADOTTE Projects
Organisme : Région Auvergne Rhone-Alpes
ID : ERATOSHENE PAI project
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