Histopathological Evaluation of Gastric Mucosal Atrophy for Predicting Gastric Cancer Risk: Problems and Solutions.

Helicobacter pylori OLGA/OLGIM autoimmune gastritis chronic atrophic gastritis gastric cancer intestinal metaplasia

Journal

Diagnostics (Basel, Switzerland)
ISSN: 2075-4418
Titre abrégé: Diagnostics (Basel)
Pays: Switzerland
ID NLM: 101658402

Informations de publication

Date de publication:
26 Jul 2023
Historique:
received: 24 06 2023
revised: 19 07 2023
accepted: 24 07 2023
medline: 12 8 2023
pubmed: 12 8 2023
entrez: 12 8 2023
Statut: epublish

Résumé

Patients suffering from chronic gastritis and developing gastric mucosa atrophy are at increased risk of the development of gastric cancer. The diagnosis of chronic atrophic gastritis (CAG) is a complex procedure involving a detailed history taking, a thorough physical examination and the use of laboratory and instrumental diagnostic methods among which the endoscopy of the upper digestive tract is the cornerstone because it allows the assessment of the topography of gastritis and identification of erosions and areas of intestinal metaplasia with the use of NBI endoscopy. However, the diagnosis of CAG requires morphological examination of the gastric mucosa. So, in addition to assessing macroscopic changes in the gastric mucosa, it is necessary to take biopsy specimens in accordance with the protocols for their morphological and immunohistochemical examination. In the absence of specific diagnostic stigmas of CAG, close cooperation between a clinician, endoscopist and pathologist is necessary. The article presents systematized data on the histopathological assessment of the gastric mucosa atrophy to predict the risk of gastric cancer.

Identifiants

pubmed: 37568841
pii: diagnostics13152478
doi: 10.3390/diagnostics13152478
pmc: PMC10417051
pii:
doi:

Types de publication

Journal Article Review

Langues

eng

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Auteurs

Maria A Livzan (MA)

Department of Internal Medicine and Gastroenterology, Omsk Sate Medical University, 644099 Omsk, Russia.

Sergei I Mozgovoi (SI)

Department of Pathological Anatomy, Omsk Sate Medical University, 644099 Omsk, Russia.

Olga V Gaus (OV)

Department of Internal Medicine and Gastroenterology, Omsk Sate Medical University, 644099 Omsk, Russia.

Anna G Shimanskaya (AG)

Department of Pathological Anatomy, Omsk Sate Medical University, 644099 Omsk, Russia.

Alexei V Kononov (AV)

Department of Pathological Anatomy, Omsk Sate Medical University, 644099 Omsk, Russia.

Classifications MeSH