Navigating the Blood-Brain Barrier: Challenges and Therapeutic Strategies in Breast Cancer Brain Metastases.
blood–tumor barrier
immunotherapy
pathogenesis
therapeutic advantages
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
27 Jul 2023
27 Jul 2023
Historique:
received:
19
06
2023
revised:
24
07
2023
accepted:
25
07
2023
medline:
14
8
2023
pubmed:
12
8
2023
entrez:
12
8
2023
Statut:
epublish
Résumé
Breast cancer (BC) is the most common cancer in women, with metastatic BC being responsible for the highest number of deaths. A frequent site for BC metastasis is the brain. Brain metastasis derived from BC involves the cooperation of multiple genetic, epigenetic, angiogenic, and tumor-stroma interactions. Most of these interactions provide a unique opportunity for development of new therapeutic targets. Potentially targetable signaling pathways are Notch, Wnt, and the epidermal growth factor receptors signaling pathways, all of which are linked to driving BC brain metastasis (BCBM). However, a major challenge in treating brain metastasis remains the blood-brain barrier (BBB). This barrier restricts the access of unwanted molecules, cells, and targeted therapies to the brain parenchyma. Moreover, current therapies to treat brain metastases, such as stereotactic radiosurgery and whole-brain radiotherapy, have limited efficacy. Promising new drugs like phosphatase and kinase modulators, as well as BBB disruptors and immunotherapeutic strategies, have shown the potential to ease the disease in preclinical studies, but remain limited by multiple resistance mechanisms. This review summarizes some of the current understanding of the mechanisms involved in BC brain metastasis and highlights current challenges as well as opportunities in strategic designs of potentially successful future therapies.
Identifiants
pubmed: 37569410
pii: ijms241512034
doi: 10.3390/ijms241512034
pmc: PMC10418424
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Natural Sciences and Engineering Research Council
ID : RGPIN/5539
Organisme : Natural Sciences and Engineering Research Council
ID : RGPIN-2021-03348
Organisme : Canadian Institute of Health Research
ID : 202103CRP-471360
Organisme : Cancer Research Society
ID : 8431003
Références
Acta Neuropathol. 2016 Mar;131(3):347-63
pubmed: 26711460
Mod Pathol. 2007 Aug;20(8):864-70
pubmed: 17541441
Asian J Surg. 2022 Nov;45(11):2259-2267
pubmed: 35012859
Cancer Lett. 2018 Mar 28;417:112-123
pubmed: 29306018
Transl Oncol. 2010 Apr;3(2):65-79
pubmed: 20360931
Oncoimmunology. 2022 Jul 4;11(1):2096363
pubmed: 35800158
Cancers (Basel). 2017 Apr 12;9(4):
pubmed: 28417948
Br J Cancer. 2017 May 23;116(11):1425-1435
pubmed: 28441382
J Biol Chem. 2003 Jun 13;278(24):21631-8
pubmed: 12690099
Clin Cancer Res. 2008 Jul 1;14(13):4059-66
pubmed: 18593982
Cancers (Basel). 2022 Jun 25;14(13):
pubmed: 35804890
Ann Oncol. 2010 May;21(5):942-8
pubmed: 19840953
Nat Rev Clin Oncol. 2021 Nov;18(11):696-714
pubmed: 34253912
Eur J Surg Oncol. 2011 Jul;37(7):635-42
pubmed: 21664097
J Neurosci. 2019 Jan 23;39(4):743-757
pubmed: 30504279
NPJ Precis Oncol. 2018 Feb 16;2(1):4
pubmed: 29872722
Clin Cancer Res. 2006 Jan 15;12(2):569-76
pubmed: 16428502
Carcinogenesis. 2011 Mar;32(3):434-42
pubmed: 21173432
Cancer Discov. 2019 Dec;9(12):1720-1735
pubmed: 31578185
Breast Cancer Res Treat. 2014 Aug;147(1):103-12
pubmed: 25106661
Arch Pathol Lab Med. 2004 Sep;128(9):974-9
pubmed: 15335267
Proc Natl Acad Sci U S A. 2014 Jan 21;111(3):984-9
pubmed: 24395782
Patholog Res Int. 2010 Dec 29;2011:920509
pubmed: 21253507
Cancer Discov. 2015 Nov;5(11):1164-1177
pubmed: 26410082
Int J Mol Sci. 2021 May 05;22(9):
pubmed: 34063168
Nat Neurosci. 2011 Oct 26;14(11):1398-1405
pubmed: 22030551
Cancer Res. 2007 May 1;67(9):4190-8
pubmed: 17483330
Oncogene. 2020 Jan;39(1):64-78
pubmed: 31462709
Oncotarget. 2017 Jul 26;8(48):83734-83744
pubmed: 29137378
Nature. 2015 Nov 5;527(7576):100-104
pubmed: 26479035
Mol Cancer. 2017 Jun 7;16(1):100
pubmed: 28592260
Oncol Lett. 2020 Apr;19(4):3349-3355
pubmed: 32256828
Br J Cancer. 2021 Jan;124(1):142-155
pubmed: 33250512
Clin Pharmacol Ther. 2015 Apr;97(4):395-403
pubmed: 25670036
Breast Cancer. 2018 Jul;25(4):392-401
pubmed: 29086897
Clin Exp Metastasis. 2010 Feb;27(2):97-105
pubmed: 18814042
Cancer Biol Med. 2015 Dec;12(4):342-54
pubmed: 26779371
Oncotarget. 2015 Feb 28;6(6):3932-46
pubmed: 25668816
Histol Histopathol. 2012 Jun;27(6):785-92
pubmed: 22473698
Curr Neuropharmacol. 2008 Sep;6(3):179-92
pubmed: 19506719
Cancers (Basel). 2020 Apr 19;12(4):
pubmed: 32325878
Cancers (Basel). 2020 Oct 31;12(11):
pubmed: 33142701
Autophagy. 2017;13(11):1905-1923
pubmed: 28981380
Breast. 2014 Oct;23(5):637-43
pubmed: 25017122
Nature. 2019 Sep;573(7775):526-531
pubmed: 31534217
World J Clin Oncol. 2014 Aug 10;5(3):382-92
pubmed: 25114853
Proc Natl Acad Sci U S A. 2002 Feb 5;99(3):1491-6
pubmed: 11792859
Cancer Biol Ther. 2009 Sep;8(17):1608-14
pubmed: 19625779
Nat Rev Mol Cell Biol. 2001 Feb;2(2):127-37
pubmed: 11252954
Int J Oncol. 2020 Dec;57(6):1245-1261
pubmed: 33174058
Nature. 2019 May;569(7757):560-564
pubmed: 31118521
Oncotarget. 2016 Jan 12;7(2):1529-43
pubmed: 26625314
Front Oncol. 2017 Dec 11;7:298
pubmed: 29312881
Int J Cancer. 2015 Mar 15;136(6):1296-307
pubmed: 25046141
Neuro Oncol. 2018 Oct 9;20(11):1439-1449
pubmed: 29566179
Breast Cancer Res. 2012 Mar 19;14(2):R49
pubmed: 22429330
Cancers (Basel). 2022 May 23;14(10):
pubmed: 35626173
CA Cancer J Clin. 2021 May;71(3):209-249
pubmed: 33538338
Cancer Res. 2018 Aug 1;78(15):4316-4330
pubmed: 30026327
Br J Cancer. 2019 Dec;121(12):991-1000
pubmed: 31719684
Pharm Res. 2018 Jul 12;35(9):177
pubmed: 30003344
Mol Cancer Ther. 2020 May;19(5):1134-1147
pubmed: 32127468
Proc Natl Acad Sci U S A. 2009 Jun 30;106(26):10666-71
pubmed: 19541645
Cold Spring Harb Perspect Biol. 2014 Jun 02;6(6):
pubmed: 24890514
J Hematol Oncol. 2021 Jun 30;14(1):102
pubmed: 34193217
ESMO Open. 2018 Oct 24;3(6):e000440
pubmed: 30425844
Expert Opin Biol Ther. 2011 Nov;11(11):1543-50
pubmed: 21895539
Biology (Basel). 2023 May 09;12(5):
pubmed: 37237509
PLoS One. 2013 Dec 04;8(12):e80933
pubmed: 24324647
Semin Cancer Biol. 2020 Feb;60:14-27
pubmed: 31421262
Ann Oncol. 2011 Jul;22(7):1571-1581
pubmed: 21059640
Drug Resist Updat. 2016 Jul;27:14-29
pubmed: 27449595
Breast Cancer Res. 2011;13(6):R125
pubmed: 22132754
Semin Cancer Biol. 2021 Jul;72:198-213
pubmed: 32461152
Cancer Cell. 2014 Apr 14;25(4):501-15
pubmed: 24735924
Springerplus. 2015 Oct 07;4:585
pubmed: 26543720
Nat Rev Cancer. 2009 Jul;9(7):463-75
pubmed: 19536107
EMBO Mol Med. 2021 May 7;13(5):e13412
pubmed: 33755340
Lancet Oncol. 2012 May;13(5):459-65
pubmed: 22456429
Nat Rev Neurosci. 2006 Jan;7(1):41-53
pubmed: 16371949
Int J Radiat Oncol Biol Phys. 2017 Sep 1;99(1):31-40
pubmed: 28816158
Cancer Discov. 2020 Jan;10(1):86-103
pubmed: 31601552
Oncoimmunology. 2013 Dec 1;2(12):e26968
pubmed: 24498562
NPJ Precis Oncol. 2019 Oct 3;3:24
pubmed: 31602400
PLoS One. 2013 Jul 04;8(7):e67811
pubmed: 23861811
Nat Med. 2022 Sep;28(9):1840-1847
pubmed: 35941372
Clin Breast Cancer. 2003 Jun;4(2):114-9
pubmed: 12864939
Mol Cancer Ther. 2019 Feb;18(2):437-447
pubmed: 30401696
Dev Cell. 2011 Aug 16;21(2):193-215
pubmed: 21839917
Ann Oncol. 2014 Sep;25(9):1735-1742
pubmed: 24907636
Cancer Discov. 2015 Feb;5(2):118-23
pubmed: 25656898
Clin Cancer Res. 2010 Dec 1;16(23):5664-78
pubmed: 20829328
Cancers (Basel). 2021 Sep 25;13(19):
pubmed: 34638283
Cancer Genet Cytogenet. 2010 Dec;203(2):222-9
pubmed: 21156237
Neuro Oncol. 2019 Nov 4;21(11):1401-1411
pubmed: 31173106
Glia. 2010 Sep;58(12):1477-89
pubmed: 20549749
Oncogene. 2013 Aug 29;32(35):4064-77
pubmed: 23001042
Front Cell Neurosci. 2014 Aug 04;8:211
pubmed: 25136294
Cell Mol Life Sci. 2019 Mar;76(6):1081-1092
pubmed: 30523362
Int J Mol Sci. 2020 Jan 15;21(2):
pubmed: 31952355
Cancer Immunol Res. 2018 Sep;6(9):1039-1045
pubmed: 30002157
Physiol Rev. 2019 Jan 1;99(1):21-78
pubmed: 30280653
Biomed Res Int. 2020 Apr 6;2020:7461727
pubmed: 32337272
NPJ Breast Cancer. 2021 Sep 14;7(1):121
pubmed: 34521857
Clin Transl Oncol. 2023 May;25(5):1218-1241
pubmed: 36897508
Clin Cancer Res. 2016 Nov 1;22(21):5287-5299
pubmed: 27245829
Eur J Cancer. 2009 Nov;45(16):2792-8
pubmed: 19643597
Anticancer Res. 2015 Feb;35(2):865-74
pubmed: 25667468
Cancers (Basel). 2022 Aug 31;14(17):
pubmed: 36077791
Clin Cancer Res. 2018 Jan 1;24(1):95-105
pubmed: 29061641
Ecancermedicalscience. 2013 Apr 18;7:307
pubmed: 23662165
J Clin Med. 2015 Nov 27;4(12):1960-76
pubmed: 26633531
Cancer Cell. 2023 Mar 13;41(3):546-572
pubmed: 36917952
Int J Mol Sci. 2021 Aug 05;22(16):
pubmed: 34445128
Adv Exp Med Biol. 2021;1187:183-204
pubmed: 33983579
Int J Radiat Oncol Biol Phys. 2012 Apr 1;82(5):2111-7
pubmed: 21497451
EMBO Mol Med. 2013 Mar;5(3):384-96
pubmed: 23495140
Glia. 2018 Nov;66(11):2438-2455
pubmed: 30357946
Exp Oncol. 2021 Jun;43(2):180-184
pubmed: 34190516
Front Biosci (Landmark Ed). 2017 Jun 1;22(10):1805-1829
pubmed: 28410147
Sci Rep. 2018 Jul 17;8(1):10784
pubmed: 30018387
J Neuroimmunol. 2010 Dec 15;229(1-2):180-91
pubmed: 20832870
Breast Cancer Res. 2020 Nov 2;22(1):120
pubmed: 33138866
Clin Cancer Res. 2015 May 15;21(10):2305-14
pubmed: 25688159
J Clin Oncol. 2013 Jan 1;31(1):65-72
pubmed: 23213105
J Clin Oncol. 2004 Sep 1;22(17):3608-17
pubmed: 15337811
Lancet Oncol. 2021 Jan;22(1):e7-e17
pubmed: 33387511
Cells. 2019 Sep 20;8(10):
pubmed: 31547193
Antioxidants (Basel). 2020 Aug 13;9(8):
pubmed: 32823544
Cancer Metastasis Rev. 2020 Sep;39(3):711-720
pubmed: 32399646
Breast Cancer Res Treat. 2018 Oct;171(3):637-648
pubmed: 29938395
J Biomed Biotechnol. 2010;2010:956897
pubmed: 20490282
Int J Cancer. 2023 Feb 15;152(4):616-634
pubmed: 36279902
Breast Cancer Res. 2009;11(4):208
pubmed: 19744307
Nature. 2009 Jun 18;459(7249):1005-9
pubmed: 19421193
Nature. 2016 May 18;533(7604):493-498
pubmed: 27225120
Ther Adv Med Oncol. 2021 Jan 31;13:1758835920986749
pubmed: 33613695
Fluids Barriers CNS. 2012 Nov 09;9(1):23
pubmed: 23140302
Ann Transl Med. 2018 May;6(9):163
pubmed: 29911111
Cancer. 2012 Oct 1;118(19):4652-9
pubmed: 22359359
Int J Mol Sci. 2022 Jun 18;23(12):
pubmed: 35743249
Sci Rep. 2019 Apr 29;9(1):6620
pubmed: 31036836
Nat Med. 2016 Jul;22(7):723-6
pubmed: 27270588
Cancers (Basel). 2021 Aug 17;13(16):
pubmed: 34439289
Oncotarget. 2020 Feb 11;11(6):650-669
pubmed: 32110283
Neuro Oncol. 2019 Nov 4;21(11):1344-1345
pubmed: 31515554
Transl Oncol. 2022 Jun;20:101405
pubmed: 35339889
Front Genet. 2023 Mar 22;14:1134779
pubmed: 37035739
N Engl J Med. 2012 Feb 9;366(6):520-9
pubmed: 22149876
Oncologist. 2021 Mar;26(3):231-241
pubmed: 33103803
Int J Cancer. 2021 Feb 15;148(4):961-970
pubmed: 32748402
Lancet Oncol. 2018 May;19(5):672-681
pubmed: 29602646
Oncotarget. 2015 Jun 20;6(17):15482-93
pubmed: 26098772
Mol Cancer Res. 2011 Jul;9(7):834-44
pubmed: 21665937
Fluids Barriers CNS. 2020 Nov 18;17(1):69
pubmed: 33208141
JAMA Netw Open. 2020 Sep 1;3(9):e2015444
pubmed: 32902650
JAMA. 1998 Nov 4;280(17):1485-9
pubmed: 9809728
Front Mol Neurosci. 2023 Jan 09;15:1072046
pubmed: 36698776
Cancer Med. 2019 May;8(5):1943-1957
pubmed: 31004402
Cancer Med. 2023 Jan;12(2):1007-1024
pubmed: 35822637
Cell. 2014 Feb 27;156(5):1002-16
pubmed: 24581498
PLoS One. 2016 Sep 20;11(9):e0163387
pubmed: 27649506
Cancer Res. 2009 Sep 1;69(17):6790-8
pubmed: 19706761
Immunity. 2021 Oct 12;54(10):2194-2208
pubmed: 34644556
Clin Med Res. 2009 Jun;7(1-2):4-13
pubmed: 19574486
N Engl J Med. 2018 Aug 23;379(8):722-730
pubmed: 30134131
Oncotarget. 2015 Sep 8;6(26):22653-65
pubmed: 26093087