Untargeted Multiomics Approach Coupling Lipidomics and Metabolomics Profiling Reveals New Insights in Diabetic Retinopathy.
diabetic retinopathy
lipidomics
metabolomics
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
27 Jul 2023
27 Jul 2023
Historique:
received:
03
07
2023
revised:
20
07
2023
accepted:
21
07
2023
medline:
14
8
2023
pubmed:
12
8
2023
entrez:
12
8
2023
Statut:
epublish
Résumé
Diabetic retinopathy (DR) is a microvascular complication of diabetes mellitus (DM) which is the main cause of vision loss in the working-age population. Currently known risk factors such as age, disease duration, and hemoglobin A1c lack sufficient efficiency to distinguish patients with early stages of DR. A total of 194 plasma samples were collected from patients with type 2 DM and DR (moderate to proliferative (PDR) or control (no or mild DR) matched for age, gender, diabetes duration, HbA1c, and hypertension. Untargeted lipidomic and metabolomic approaches were performed. Partial-least square methods were used to analyze the datasets. Levels of 69 metabolites and 85 lipid species were found to be significantly different in the plasma of DR patients versus controls. Metabolite set enrichment analysis indicated that pathways such as metabolism of branched-chain amino acids (methylglutaryl carnitine
Identifiants
pubmed: 37569425
pii: ijms241512053
doi: 10.3390/ijms241512053
pmc: PMC10418671
pii:
doi:
Substances chimiques
Lipids
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Société Francophone du Diabète
ID : 1A97B89D335F474DABFE9ED1DCA22D6A
Organisme : GIRCI méditerrannée
ID : AAP 2020 VALO DATA
Références
Am J Ophthalmol. 2022 Mar;235:154-162
pubmed: 34587493
J Proteome Res. 2009 Nov;8(11):5132-41
pubmed: 19754161
Ophthalmology. 2003 Sep;110(9):1677-82
pubmed: 13129861
Diabetes. 2020 Oct;69(10):2217-2226
pubmed: 32737117
N Engl J Med. 2010 Jul 15;363(3):233-44
pubmed: 20587587
JAMA. 2010 Jun 9;303(22):2291-2
pubmed: 20530784
Diabetologia. 2019 Sep;62(9):1539-1549
pubmed: 31346658
Bioinformatics. 2015 May 1;31(9):1493-5
pubmed: 25527831
Heliyon. 2023 Mar 31;9(4):e15123
pubmed: 37089301
Lancet. 2007 Nov 17;370(9600):1687-97
pubmed: 17988728
PLoS One. 2014 May 16;9(5):e97302
pubmed: 24837086
Neurotox Res. 2019 Jul;36(1):81-90
pubmed: 30830678
J Lipid Res. 2008 May;49(5):1137-46
pubmed: 18281723
Diabetologia. 2022 Apr;65(4):587-603
pubmed: 35149880
Metabolites. 2019 Jun 18;9(6):
pubmed: 31216675
Commun Med (Lond). 2023 Jan 9;3(1):5
pubmed: 36624208
Mol Vis. 2009 Aug 17;15:1620-30
pubmed: 19693289
World J Diabetes. 2019 Mar 15;10(3):140-153
pubmed: 30891150
Am J Physiol Heart Circ Physiol. 2015 Sep;309(5):H935-45
pubmed: 26071539
Invest Ophthalmol Vis Sci. 2019 Jul 1;60(8):3119-3126
pubmed: 31323682
Clin Pract. 2022 Jun 29;12(4):457-467
pubmed: 35892436
J Clin Endocrinol Metab. 2020 Apr 1;105(4):
pubmed: 31589290
J Diabetes. 2018 May;10(5):350-352
pubmed: 29369529
Prog Retin Eye Res. 2019 Mar;69:57-79
pubmed: 30423446
Sci Rep. 2021 May 6;11(1):9727
pubmed: 33958610
Trends Biochem Sci. 2016 Nov;41(11):954-969
pubmed: 27663237
Magn Reson Chem. 2023 Apr 2;:
pubmed: 37005774
Pharmaceutics. 2022 Dec 08;14(12):
pubmed: 36559245
Amino Acids. 2013 Sep;45(3):413-8
pubmed: 22526238
Front Endocrinol (Lausanne). 2022 Sep 08;13:986303
pubmed: 36157454
Invest Ophthalmol Vis Sci. 2002 Aug;43(8):2791-8
pubmed: 12147617
Front Endocrinol (Lausanne). 2021 Oct 29;12:757088
pubmed: 34777253
Int J Mol Sci. 2019 May 18;20(10):
pubmed: 31109071
Cochrane Database Syst Rev. 2023 Feb 22;2:CD013775
pubmed: 36815723
Cell Metab. 2017 Jan 10;25(1):43-56
pubmed: 28094011
Ophthalmology. 2021 Nov;128(11):1580-1591
pubmed: 33940045
Clin Chim Acta. 2011 May 12;412(11-12):940-5
pubmed: 21276784
Cell Rep. 2014 Oct 23;9(2):661-73
pubmed: 25373904
Nat Protoc. 2022 Aug;17(8):1735-1761
pubmed: 35715522
PLoS One. 2011;6(7):e21230
pubmed: 21760889
Diabetes Care. 2012 Mar;35(3):556-64
pubmed: 22301125
Adv Sci (Weinh). 2020 Oct 01;7(22):2001714
pubmed: 33240754
Metabolomics. 2018;14(7):89
pubmed: 29950956
Arterioscler Thromb Vasc Biol. 2020 Oct;40(10):2527-2538
pubmed: 32757649
Surv Ophthalmol. 2022 Sep-Oct;67(5):1332-1345
pubmed: 35430245
Invest Ophthalmol Vis Sci. 2010 Sep;51(9):4416-21
pubmed: 20375324
Science. 2002 Oct 25;298(5594):763-4
pubmed: 12399572
Diabetes. 2016 Apr;65(4):1099-108
pubmed: 26822086
Brain Res. 2004 Aug 20;1018(1):66-72
pubmed: 15262206
Int J Endocrinol. 2014;2014:651050
pubmed: 24688543
Metabolomics. 2016;12:15
pubmed: 26617478
Metabolites. 2022 May 07;12(5):
pubmed: 35629925
Front Endocrinol (Lausanne). 2022 Oct 27;13:1037164
pubmed: 36387907
Nutr Metab (Lond). 2019 May 28;16:37
pubmed: 31160916
Cells. 2022 Sep 26;11(19):
pubmed: 36230967
J Clin Med. 2019 Jun 19;8(6):
pubmed: 31248127