Melanocortin 1 Receptor (MC1R): Pharmacological and Therapeutic Aspects.
disease
melanocortin
modulator
peptide
receptor
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
29 Jul 2023
29 Jul 2023
Historique:
received:
21
05
2023
revised:
22
06
2023
accepted:
27
07
2023
medline:
14
8
2023
pubmed:
12
8
2023
entrez:
12
8
2023
Statut:
epublish
Résumé
Melanocortins play crucial roles in regulating the stress response, inflammation, and skin pigmentation. In this review, we focus on the melanocortin 1 receptor (MC1R), a G protein-coupled receptor primarily known for regulating skin pigmentation and exhibiting anti-inflammatory effects. First, we provide an overview of the structure, signaling pathways, and related diseases of MC1R. Next, we discuss the potential therapeutic use of synthetic peptides and small molecule modulators of MC1R, highlighting the development of various drugs that enhance stability through amino acid sequence modifications and small molecule drugs to overcome limitations associated with peptide characteristics. Notably, MC1R-targeted drugs have applications beyond skin pigmentation-related diseases, which predominantly affect MC1R in melanocytes. These drugs can also be useful in treating inflammatory diseases with MC1R expression present in various cells. Our review underscores the potential of MC1R-targeted drugs to treat a wide range of diseases and encourages further research in this area.
Identifiants
pubmed: 37569558
pii: ijms241512152
doi: 10.3390/ijms241512152
pmc: PMC10418475
pii:
doi:
Substances chimiques
Peptides
0
Receptor, Melanocortin, Type 1
0
MC1R protein, human
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : National Science Foundation of Korea
ID : NRF-2020R1A6A1A03043708 and NRF-2021R1A2C1012280
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