Tetracyclic 1,4-Naphthoquinone Thioglucoside Conjugate U-556 Blocks the Purinergic P2X7 Receptor in Macrophages and Exhibits Anti-Inflammatory Activity In Vivo.
1,4-naphthoquinone
Ca2+ influx
P2X7 receptor
ROS production
SPR analysis
YO-PRO-1 uptake
inflammation
macrophages
molecular docking
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
02 Aug 2023
02 Aug 2023
Historique:
received:
28
04
2023
revised:
21
07
2023
accepted:
31
07
2023
medline:
14
8
2023
pubmed:
12
8
2023
entrez:
12
8
2023
Statut:
epublish
Résumé
P2X7 receptors (P2X7Rs) are ligand-gated ion channels that play a significant role in inflammation and are considered a potential therapeutic target for some inflammatory diseases. We have previously shown that a number of synthetic 1,4-naphthoquinones are capable of blocking P2X7Rs in neuronal and macrophage cells. In the present investigation, we have demonstrated the ability of the tetracyclic quinone-thioglucoside conjugate
Identifiants
pubmed: 37569745
pii: ijms241512370
doi: 10.3390/ijms241512370
pmc: PMC10418395
pii:
doi:
Substances chimiques
1,4-naphthoquinone
RBF5ZU7R7K
Receptors, Purinergic P2X7
0
Naphthoquinones
0
Anti-Inflammatory Agents
0
Adenosine Triphosphate
8L70Q75FXE
Thioglucosides
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
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