Bioengineered Kidney Tubules Efficiently Clear Uremic Toxins in Experimental Dialysis Conditions.
bioartificial kidney
dialysis fluid
proximal tubule epithelial cells
uremic plasma
uremic toxins
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
04 Aug 2023
04 Aug 2023
Historique:
received:
07
07
2023
revised:
25
07
2023
accepted:
02
08
2023
medline:
14
8
2023
pubmed:
12
8
2023
entrez:
12
8
2023
Statut:
epublish
Résumé
Patients with end-stage kidney disease (ESKD) suffer from high levels of protein-bound uremic toxins (PBUTs) that contribute to various comorbidities. Conventional dialysis methods are ineffective in removing these PBUTs. A potential solution could be offered by a bioartificial kidney (BAK) composed of porous membranes covered by proximal tubule epithelial cells (PTECs) that actively secrete PBUTs. However, BAK development is currently being hampered by a lack of knowledge regarding the cytocompatibility of the dialysis fluid (DF) that comes in contact with the PTECs. Here, we conducted a comprehensive functional assessment of the DF on human conditionally immortalized PTECs (ciPTECs) cultured as monolayers in well plates, on Transwell
Identifiants
pubmed: 37569805
pii: ijms241512435
doi: 10.3390/ijms241512435
pmc: PMC10419568
pii:
doi:
Substances chimiques
Uremic Toxins
0
Dialysis Solutions
0
Toxins, Biological
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : European Union's Horizon 2020 - Marie Skłodowska-Curie
ID : 813839
Organisme : European Union's Horizon EIC Pathfinder Open programme
ID : 101099092
Organisme : Strategic Alliance of the University of Twente, University of Utrecht and University Medical Center Utrecht
Références
Sci Rep. 2017 Jul 10;7(1):4939
pubmed: 28694431
Nat Rev Nephrol. 2019 May;15(5):301-316
pubmed: 30728454
Sci Rep. 2016 May 31;6:26715
pubmed: 27242131
Sci Rep. 2021 Jul 7;11(1):14053
pubmed: 34234242
Semin Nephrol. 2014 Mar;34(2):191-208
pubmed: 24780473
Sci Rep. 2015 Nov 16;5:16702
pubmed: 26567716
Sci Rep. 2017 Aug 2;7(1):7103
pubmed: 28769101
Clin J Am Soc Nephrol. 2021 Oct;16(10):1531-1538
pubmed: 34233922
J Am Soc Nephrol. 2012 Jul;23(7):1258-70
pubmed: 22626821
Biochim Biophys Acta Gen Subj. 2020 Jan;1864(1):129433
pubmed: 31520681
Kidney Int. 1987 Jul;32(1):129-35
pubmed: 3306095
Acta Biomater. 2019 Aug;94:11-24
pubmed: 31226477
Int J Nephrol Renovasc Dis. 2021 Jan 20;14:11-21
pubmed: 33505168
AAPS J. 2016 Mar;18(2):465-75
pubmed: 26821801
Am J Nephrol. 2012;36(5):438-43
pubmed: 23128155
Nephrol Dial Transplant. 2012 Apr;27(4):1574-9
pubmed: 22231033
Toxins (Basel). 2022 Mar 17;14(3):
pubmed: 35324718
Proc Clin Dial Transplant Forum. 1976 Nov 19-22;6:73-9
pubmed: 1029892
Kidney Int. 2003 May;63(5):1934-43
pubmed: 12675874
Annu Rev Pharmacol Toxicol. 2023 Jan 20;63:637-660
pubmed: 36206988
Biomedicines. 2021 Sep 26;9(10):
pubmed: 34680443
Physiol Rev. 2015 Jan;95(1):83-123
pubmed: 25540139
Proc Natl Acad Sci U S A. 2019 Aug 6;116(32):16105-16110
pubmed: 31341083
Drug Metab Dispos. 2018 May;46(5):592-599
pubmed: 29514829
Mol Pharm. 2019 Nov 4;16(11):4551-4562
pubmed: 31525064
Clin J Am Soc Nephrol. 2021 Dec;16(12):1918-1928
pubmed: 34233920
Toxins (Basel). 2023 Mar 25;15(4):
pubmed: 37104179
Am J Physiol. 1989 Mar;256(3 Pt 2):F475-84
pubmed: 2466412
Front Bioeng Biotechnol. 2022 Sep 07;10:958582
pubmed: 36159671
J Cell Mol Med. 2013 Apr;17(4):497-507
pubmed: 23480720
Toxins (Basel). 2020 Jun 12;12(6):
pubmed: 32545617
PLoS One. 2011 Apr 04;6(4):e18438
pubmed: 21483698
Nat Rev Nephrol. 2023 Aug;19(8):481-490
pubmed: 37277461
Pediatr Nephrol. 2014 Mar;29(3):343-51
pubmed: 23619508
Int J Artif Organs. 2017 Jul 5;40(7):323-327
pubmed: 28623640
Nefrologia. 2007;27(6):742-8
pubmed: 18336105
Reprod Med Biol. 2017 Mar 21;16(2):99-117
pubmed: 29259457
Toxins (Basel). 2020 Apr 07;12(4):
pubmed: 32272776
J Pharm Sci. 2015 Dec;104(12):4448-4458
pubmed: 26457988
Clin J Am Soc Nephrol. 2015 Nov 6;10(11):2039-49
pubmed: 26490509
Semin Dial. 2017 Mar;30(2):112-120
pubmed: 28066927
Blood Purif. 2022;51(6):548-558
pubmed: 34515053
Pharmacol Ther. 2022 Jan;229:107938
pubmed: 34171335
Expert Rev Med Devices. 2018 May;15(5):323-336
pubmed: 29633900