An Update on Toll-like Receptor 2, Its Function and Dimerization in Pro- and Anti-Inflammatory Processes.
Toll-like receptor 2
dimerization
heterodimerization
homodimerization
inflammation
neurodegeneration
neuroinflammation
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
05 Aug 2023
05 Aug 2023
Historique:
received:
09
07
2023
revised:
01
08
2023
accepted:
03
08
2023
medline:
14
8
2023
pubmed:
12
8
2023
entrez:
12
8
2023
Statut:
epublish
Résumé
While a certain level of inflammation is critical for humans to survive infection and injury, a prolonged inflammatory response can have fatal consequences. Pattern recognition Toll-like receptors (TLRs) are key players in the initiation of an inflammatory process. TLR2 is one of the most studied pattern recognition receptors (PRRs) and is known to form heterodimers with either TLR1, TLR4, TLR6, and TLR10, allowing it to recognize a wide range of pathogens. Although a large number of studies have been conducted over the past decades, there are still many unanswered questions regarding TLR2 mechanisms in health and disease. In this review, we provide an up-to-date overview of TLR2, including its homo- and heterodimers. Furthermore, we will discuss the pro- and anti-inflammatory properties of TLR2 and recent findings in prominent TLR2-associated infectious and neurodegenerative diseases.
Identifiants
pubmed: 37569837
pii: ijms241512464
doi: 10.3390/ijms241512464
pmc: PMC10419760
pii:
doi:
Substances chimiques
Toll-Like Receptor 2
0
Toll-Like Receptor 1
0
Toll-Like Receptors
0
Anti-Inflammatory Agents
0
Toll-Like Receptor 6
0
Toll-Like Receptor 10
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : FTI Program
ID : K3-F-744/005-2019
Organisme : Austrian Research Promotion Agency (FFG)
ID : 35467434
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