YAP at the Crossroads of Biomechanics and Drug Resistance in Human Cancer.
CRISPR/Cas9 imaging
bioengineering
biomechanics
cancer
drug resistance
extracellular matrix (ECM)
mechanobiology
mechanomedicine
yes-associated protein (YAP)
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
06 Aug 2023
06 Aug 2023
Historique:
received:
15
07
2023
revised:
30
07
2023
accepted:
04
08
2023
medline:
14
8
2023
pubmed:
12
8
2023
entrez:
12
8
2023
Statut:
epublish
Résumé
Biomechanical forces are of fundamental importance in biology, diseases, and medicine. Mechanobiology is an emerging interdisciplinary field that studies how biological mechanisms are regulated by biomechanical forces and how physical principles can be leveraged to innovate new therapeutic strategies. This article reviews state-of-the-art mechanobiology knowledge about the yes-associated protein (YAP), a key mechanosensitive protein, and its roles in the development of drug resistance in human cancer. Specifically, the article discusses three topics: how YAP is mechanically regulated in living cells; the molecular mechanobiology mechanisms by which YAP, along with other functional pathways, influences drug resistance of cancer cells (particularly lung cancer cells); and finally, how the mechanical regulation of YAP can influence drug resistance and vice versa. By integrating these topics, we present a unified framework that has the potential to bring theoretical insights into the design of novel mechanomedicines and advance next-generation cancer therapies to suppress tumor progression and metastasis.
Identifiants
pubmed: 37569866
pii: ijms241512491
doi: 10.3390/ijms241512491
pmc: PMC10419175
pii:
doi:
Substances chimiques
Transcription Factors
0
Adaptor Proteins, Signal Transducing
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIGMS NIH HHS
ID : R35 GM128753
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM146877
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM150812
Pays : United States
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