Phosphatidylcholine-Specific Phospholipase C as a Promising Drug Target.
atherosclerosis
cancer
drug discovery
inflammation
inhibitors
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
25 Jul 2023
25 Jul 2023
Historique:
received:
19
05
2023
revised:
12
07
2023
accepted:
24
07
2023
medline:
14
8
2023
pubmed:
12
8
2023
entrez:
12
8
2023
Statut:
epublish
Résumé
Phosphatidylcholine-specific phospholipase C (PC-PLC) is an enzyme that catalyzes the formation of the important secondary messengers phosphocholine and diacylglycerol (DAG) from phosphatidylcholine. Although PC-PLC has been linked to the progression of many pathological conditions, including cancer, atherosclerosis, inflammation and neuronal cell death, studies of PC-PLC on the protein level have been somewhat neglected with relatively scarce data. To date, the human gene expressing PC-PLC has not yet been found, and the only protein structure of PC-PLC that has been solved was from
Identifiants
pubmed: 37570610
pii: molecules28155637
doi: 10.3390/molecules28155637
pmc: PMC10420013
pii:
doi:
Substances chimiques
phosphatidylcholine-specific phospholipase C
EC 3.1.4.3
Type C Phospholipases
EC 3.1.4.-
Phosphatidylcholines
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Références
Bioorg Med Chem. 2010 Dec 15;18(24):8549-55
pubmed: 21071231
Bioorg Chem. 2021 Sep;114:105152
pubmed: 34328856
Lipids. 2002 Apr;37(4):401-6
pubmed: 12030321
J Exp Med. 1991 Nov 1;174(5):975-88
pubmed: 1658188
Front Oncol. 2016 Jun 22;6:153
pubmed: 27446799
Int J Oral Maxillofac Surg. 2014 Dec;43(12):1418-26
pubmed: 25085076
Drug Des. 2017 Mar;6(1):
pubmed: 29354330
Cancer Res. 1992 May 15;52(10):2835-40
pubmed: 1316230
Cell. 1992 Nov 27;71(5):765-76
pubmed: 1330325
Cancer Cell Int. 2016 Mar 10;16:18
pubmed: 26966420
J Med Chem. 1973 May;16(5):560-4
pubmed: 4718475
Radiology. 2004 Nov;233(2):424-31
pubmed: 15516615
Cell. 1988 Jul 1;54(1):73-81
pubmed: 2898301
Bioorg Med Chem Lett. 2016 Jun 15;26(12):2947-2951
pubmed: 27240550
Chem Biol Drug Des. 2020 Mar;95(3):380-387
pubmed: 31442363
Bioorg Med Chem Lett. 1999 Jun 7;9(11):1619-24
pubmed: 10386947
Bioorg Med Chem. 2001 May;9(5):1073-83
pubmed: 11377165
Biochem Biophys Res Commun. 1986 Oct 15;140(1):114-9
pubmed: 3096314
Br J Cancer. 2014 Feb 4;110(3):625-35
pubmed: 24335926
Adv Exp Med Biol. 1996;416:389-96
pubmed: 9131178
Front Immunol. 2020 Aug 28;11:2109
pubmed: 32983169
Arterioscler Thromb Vasc Biol. 2007 Jan;27(1):219-25
pubmed: 17038637
Oncotarget. 2017 Dec 14;9(6):7204-7218
pubmed: 29467962
PLoS One. 2015 Sep 24;10(9):e0136120
pubmed: 26402860
J Biol Chem. 2007 Jun 15;282(24):17537-47
pubmed: 17449912
Oncogene. 2002 Sep 19;21(42):6520-9
pubmed: 12226755
Anal Biochem. 1997 Nov 15;253(2):162-8
pubmed: 9367498
Bioorg Med Chem. 2009 Apr 15;17(8):3169-76
pubmed: 19303309
Cell Biol Int. 1997 Jun;21(6):375-81
pubmed: 9268491
Biochem Biophys Res Commun. 2010 Jun 25;397(2):296-300
pubmed: 20510673
Cancers (Basel). 2020 Dec 26;13(1):
pubmed: 33375286
Cell Death Dis. 2013 Sep 19;4:e806
pubmed: 24052074
Eur J Med Chem. 2020 Feb 1;187:111919
pubmed: 31810783
CA Cancer J Clin. 2021 May;71(3):209-249
pubmed: 33538338
Proc Natl Acad Sci U S A. 1984 Jun;81(11):3263-7
pubmed: 6328507
J Physiol. 2013 Oct 15;591(20):5005-15
pubmed: 23959677
Bioorg Med Chem Lett. 2008 Feb 15;18(4):1461-7
pubmed: 18226526
Proc Natl Acad Sci U S A. 1998 Jun 23;95(13):7748-53
pubmed: 9636222
PLoS One. 2017 Apr 19;12(4):e0176108
pubmed: 28423060
J Immunol Methods. 1997 Mar 28;202(2):133-41
pubmed: 9107302
Bioorg Chem. 2019 Mar;84:98-105
pubmed: 30500524
J Leukoc Biol. 1994 Nov;56(5):533-41
pubmed: 7964160
Front Oncol. 2016 Aug 02;6:171
pubmed: 27532027
J Org Chem. 2003 Sep 19;68(19):7298-307
pubmed: 12968879
J Org Chem. 2000 Jul 28;65(15):4509-14
pubmed: 10959851
Anal Biochem. 2017 Jun 1;526:43-49
pubmed: 28315318
Acta Pharmacol Sin. 2004 Apr;25(4):442-6
pubmed: 15066210
J Med Chem. 2015 Oct 22;58(20):8128-40
pubmed: 26407012
Bioorg Med Chem. 2015 Mar 15;23(6):1231-40
pubmed: 25693787
J Cell Biochem. 2007 Apr 15;100(6):1548-57
pubmed: 17211851
Breast Cancer Res. 2010;12(3):R27
pubmed: 20462431
Arterioscler Thromb Vasc Biol. 2010 Mar;30(3):411-8
pubmed: 20139365
Curr Oncol. 2015 Aug;22(4):e273-81
pubmed: 26300678
Adv Cancer Res. 2014;124:31-82
pubmed: 25287686
Eur J Med Chem. 2010 Jul;45(7):3080-6
pubmed: 20416982
Anal Methods. 2021 Feb 4;13(4):491-496
pubmed: 33432952
Arch Pharm Res. 2004 Oct;27(10):1043-7
pubmed: 15554262
Toxicol Appl Pharmacol. 1994 Feb;124(2):165-73
pubmed: 8122261
Lab Invest. 2022 Feb;102(2):143-153
pubmed: 34697421
Nature. 1989 Mar 23;338(6213):357-60
pubmed: 2493587
J Immunol Res. 2018 Feb 8;2018:5201759
pubmed: 30057916
Sci Rep. 2019 Mar 25;9(1):5109
pubmed: 30911014
J Biol Chem. 2021 Dec;297(6):101398
pubmed: 34774525
Bioorg Med Chem. 2000 Apr;8(4):699-706
pubmed: 10819158
Biochem Int. 1984 Jan;8(1):27-33
pubmed: 6433934
NMR Biomed. 2010 Jul;23(6):633-42
pubmed: 20623626
Bioorg Chem. 2018 Feb;76:140-146
pubmed: 29175585
Angew Chem Int Ed Engl. 2004 Feb 6;43(7):862-5
pubmed: 14767959
Cancer Res. 2008 Aug 15;68(16):6541-9
pubmed: 18701477
Eur J Med Chem. 2020 Apr 1;191:112162
pubmed: 32101781
Mol Cancer. 2004 May 13;3:15
pubmed: 15140260
Cell Mol Life Sci. 2022 Mar 18;79(4):195
pubmed: 35303162
Prostaglandins. 1987 Nov;34(5):633-42
pubmed: 3124216
J Cell Physiol. 2011 Nov;226(11):2827-33
pubmed: 21302284
Anal Biochem. 1997 Aug 15;251(1):45-9
pubmed: 9300081
Lancet Neurol. 2019 May;18(5):459-480
pubmed: 30879893
Drugs Exp Clin Res. 1996;22(6):287-94
pubmed: 9034754
Biochem J. 1982 Jun 1;203(3):799-801
pubmed: 6810875
Enzyme Microb Technol. 2000 Mar 1;26(5-6):451-458
pubmed: 10713220
Crit Rev Biochem Mol Biol. 2013 Jan-Feb;48(1):20-38
pubmed: 23350810