American Ginseng for the Treatment of Alzheimer's Disease: A Review.
Alzheimer’s disease
American ginseng
ginsenosides
molecular mechanism
pathogenic mechanism
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
28 Jul 2023
28 Jul 2023
Historique:
received:
25
06
2023
revised:
19
07
2023
accepted:
26
07
2023
medline:
14
8
2023
pubmed:
12
8
2023
entrez:
12
8
2023
Statut:
epublish
Résumé
Alzheimer's disease (AD) is a prevalent degenerative condition that is increasingly affecting populations globally. American ginseng (AG) has anti-AD bioactivity, and ginsenosides, as the main active components of AG, have shown strong anti-AD effects in both in vitro and in vivo studies. It has been reported that ginsenosides can inhibit amyloid β-protein (Aβ) production and deposition, tau phosphorylation, apoptosis and cytotoxicity, as well as possess anti-oxidant and anti-inflammatory properties, thus suppressing the progression of AD. In this review, we aim to provide a comprehensive overview of the pathogenesis of AD, the potential anti-AD effects of ginsenosides found in AG, and the underlying molecular mechanisms associated with these effects. Additionally, we will discuss the potential use of AG in the treatment of AD, and how ginsenosides in AG may exert more potent anti-AD effects in vivo may be a direction for further research.
Identifiants
pubmed: 37570686
pii: molecules28155716
doi: 10.3390/molecules28155716
pmc: PMC10420665
pii:
doi:
Substances chimiques
Amyloid beta-Peptides
0
Ginsenosides
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : National Natural Science Foundation of China
ID : 81973468
Organisme : Jilin Province Science and Technology Department
ID : 20220204001YY
Organisme : Jilin Province Science and Technology Department
ID : 20230401074YY
Organisme : Jilin Provincial Development and Reform Commission
ID : 2021C035-5
Références
Neurosci Bull. 2014 Apr;30(2):271-81
pubmed: 24664866
Molecules. 2022 May 13;27(10):
pubmed: 35630607
J Alzheimers Dis Rep. 2019 Nov 21;3(1):279-297
pubmed: 31867567
Int J Mol Med. 2019 Feb;43(2):717-726
pubmed: 30535505
J Ind Microbiol Biotechnol. 2012 Apr;39(4):521-7
pubmed: 22270887
J Drug Target. 2018 Feb;26(2):182-193
pubmed: 28697660
Front Mol Neurosci. 2014 May 21;7:46
pubmed: 24904272
Neurol Res. 2009 Sep;31(7):663-7
pubmed: 19138476
Mol Med Rep. 2022 Jun;25(6):
pubmed: 35543148
Signal Transduct Target Ther. 2019 Aug 23;4:29
pubmed: 31637009
Front Pharmacol. 2022 Feb 16;13:845185
pubmed: 35250595
Front Pharmacol. 2022 Sep 22;13:937289
pubmed: 36210852
Cells. 2019 May 22;8(5):
pubmed: 31121890
Front Immunol. 2022 Oct 12;13:968520
pubmed: 36311808
Molecules. 2020 Dec 11;25(24):
pubmed: 33322293
PLoS One. 2013;8(3):e59155
pubmed: 23520555
J Biol Chem. 2013 Jul 19;288(29):20868-20882
pubmed: 23723072
Mol Neurobiol. 2022 Sep;59(9):5856-5873
pubmed: 35804281
Front Neurosci. 2019 Jun 18;13:629
pubmed: 31275108
Plants (Basel). 2022 May 31;11(11):
pubmed: 35684249
Brain Res. 2009 Jan 16;1249:222-8
pubmed: 18996097
Front Pharmacol. 2020 Jun 10;11:834
pubmed: 32587516
Brain Res Bull. 2016 Jul;125:30-43
pubmed: 27060612
Int J Mol Sci. 2023 May 11;24(10):
pubmed: 37239965
Eur J Nutr. 2022 Feb;61(1):413-428
pubmed: 34396468
J Biol Chem. 2009 Sep 4;284(36):24192-203
pubmed: 19592497
Curr Med Sci. 2020 Feb;40(1):1-8
pubmed: 32166659
Eur J Neurol. 2008 Aug;15(8):865-8
pubmed: 18684311
Neurochem Res. 2016 May;41(5):951-7
pubmed: 26738987
Behav Brain Res. 2018 Jan 30;337:160-172
pubmed: 28927718
Int J Mol Sci. 2022 Aug 11;23(16):
pubmed: 36012242
J Alzheimers Dis. 2020;76(4):1513-1526
pubmed: 32651311
Nutrients. 2021 Jun 27;13(7):
pubmed: 34199021
J Ethnopharmacol. 2007 May 22;111(3):458-63
pubmed: 17257792
Nutrients. 2019 May 09;11(5):
pubmed: 31075951
Phytother Res. 2009 Apr;23(4):486-91
pubmed: 19003949
Pathol Int. 2017 Apr;67(4):185-193
pubmed: 28261941
Phytochemistry. 2011 Jun;72(8):689-99
pubmed: 21396670
Int J Mol Sci. 2013 May 08;14(5):9820-33
pubmed: 23698769
Phytochem Anal. 2019 Jan;30(1):26-33
pubmed: 30159954
J Ethnopharmacol. 2011 Oct 31;138(1):135-41
pubmed: 21945003
Am J Neurodegener Dis. 2016 Mar 01;5(1):52-61
pubmed: 27073742
J Physiol Pharmacol. 2021 Apr;72(2):
pubmed: 34374655
Int Immunopharmacol. 2014 Apr;19(2):317-26
pubmed: 24503167
Am J Hosp Palliat Care. 2018 Jan;35(1):144-150
pubmed: 28299946
Arch Pharm Res. 2005 Oct;28(10):1164-9
pubmed: 16276974
Expert Opin Investig Drugs. 2019 Nov;28(11):967-975
pubmed: 31661331
Hum Psychopharmacol. 2015 Mar;30(2):108-22
pubmed: 25778987
Front Biosci (Landmark Ed). 2022 May 6;27(5):146
pubmed: 35638413
Mol Med Rep. 2021 Oct;24(4):
pubmed: 34368872
Neurochem Res. 2018 Aug;43(8):1529-1538
pubmed: 29926354
Neurobiol Learn Mem. 2011 Nov;96(4):529-43
pubmed: 21914486
J Exp Med. 2016 Jul 25;213(8):1375-85
pubmed: 27432942
JAMA Neurol. 2019 Jan 1;76(1):101-108
pubmed: 30193298
Molecules. 2019 Jul 24;24(15):
pubmed: 31344860
Food Sci Nutr. 2021 Jul 20;9(9):5293-5311
pubmed: 34532035
Sci Rep. 2019 Mar 13;9(1):4414
pubmed: 30867485
Regul Toxicol Pharmacol. 2016 Jul;78:53-8
pubmed: 27112419
Evid Based Complement Alternat Med. 2016;2016:5738694
pubmed: 27446225
Mini Rev Med Chem. 2022;22(3):437-448
pubmed: 34517798
Int J Mol Sci. 2022 Oct 29;23(21):
pubmed: 36361952
Curr Pharm Des. 2008;14(16):1601-5
pubmed: 18673201
CNS Neurol Disord Drug Targets. 2023;22(7):973-993
pubmed: 35770411
Mol Med Rep. 2020 Oct;22(4):3277-3288
pubmed: 32945455
Nutr Neurosci. 2012 Nov;15(6):278-82
pubmed: 22780999
Molecules. 2018 Apr 26;23(5):
pubmed: 29701672
Neurosci Lett. 2011 Jan 3;487(1):70-2
pubmed: 20933058
Mech Ageing Dev. 2021 Jul;197:111496
pubmed: 33957218
Traffic. 2019 Jan;20(1):61-70
pubmed: 30375163
Front Aging Neurosci. 2022 Sep 07;14:977411
pubmed: 36158539
FASEB J. 2006 Jun;20(8):1269-71
pubmed: 16636099
Phytomedicine. 2022 Jan;95:153883
pubmed: 34952508
Eur J Pharmacol. 2016 Dec 15;793:101-108
pubmed: 27840193
Mol Pain. 2022 Apr;18:17448069221126078
pubmed: 36039405
J Neurol Sci. 1983 May;59(2):277-89
pubmed: 6854353
Biomed Pharmacother. 2023 Feb;158:114192
pubmed: 36587558
Int J Mol Sci. 2022 Sep 19;23(18):
pubmed: 36142879
Exp Ther Med. 2021 Jul;22(1):782
pubmed: 34055081
Neuropharmacology. 2014 Apr;79:642-56
pubmed: 24467851
Free Radic Biol Med. 1997;23(1):134-47
pubmed: 9165306
Neurochem Res. 2020 May;45(5):972-988
pubmed: 32170673
Int J Mol Sci. 2020 Jun 29;21(13):
pubmed: 32610577
Molecules. 2020 Jan 02;25(1):
pubmed: 31906464
J Neurosci. 2014 May 21;34(21):7091-101
pubmed: 24849345
Cells. 2022 Sep 01;11(17):
pubmed: 36078138
Cells. 2022 Jun 14;11(12):
pubmed: 35741054
Curr Opin Neurobiol. 2020 Aug;63:53-58
pubmed: 32278210
Mol Med Rep. 2019 Apr;19(4):2975-2998
pubmed: 30816465
Front Aging Neurosci. 2022 Jun 23;14:911635
pubmed: 35813941
Drugs. 2023 Mar;83(4):359-365
pubmed: 36856953
Redox Biol. 2018 Apr;14:450-464
pubmed: 29080524
J Alzheimers Dis. 2015;45(4):1015-38
pubmed: 25697708
Behav Brain Res. 2013 Mar 15;241:228-34
pubmed: 23219964
Chem Biodivers. 2019 Jul;16(7):e1900203
pubmed: 31197924
Ageing Res Rev. 2013 Jan;12(1):39-49
pubmed: 22771380
Biomed Res Int. 2020 May 20;2020:3905719
pubmed: 32550230
Ageing Res Rev. 2013 Jan;12(1):289-309
pubmed: 22742992
J Ginseng Res. 2015 Jul;39(3):230-7
pubmed: 26199554
Mol Neurodegener. 2022 Nov 8;17(1):72
pubmed: 36348357
Life (Basel). 2022 Jan 01;12(1):
pubmed: 35054451
Biochim Biophys Acta Mol Cell Res. 2020 May;1867(5):118664
pubmed: 32006534
Phytomedicine. 2022 Sep;104:154341
pubmed: 35870376
Zhongguo Zhong Yao Za Zhi. 2001 Jun;26(6):416-9
pubmed: 12528513
Nat Rev Neurosci. 2016 Jan;17(1):5-21
pubmed: 26631930
Drug Discov Ther. 2013 Apr;7(2):46-57
pubmed: 23715502
Sci Rep. 2019 Jan 31;9(1):1079
pubmed: 30705366
Phytother Res. 2018 Dec;32(12):2531-2540
pubmed: 30277284
Front Mol Neurosci. 2022 Aug 25;15:937133
pubmed: 36090249
FEMS Microbiol Lett. 2020 Feb 1;367(4):
pubmed: 31950993
Nat Commun. 2022 Feb 22;13(1):998
pubmed: 35194025
J Cereb Blood Flow Metab. 1997 Feb;17(2):220-8
pubmed: 9040502
Evid Based Complement Alternat Med. 2017;2017:5934254
pubmed: 29422936
Chem Biol Interact. 2015 Sep 5;239:12-8
pubmed: 26111763
Biomed Pharmacother. 2022 Oct;154:113576
pubmed: 36007279
PLoS One. 2013 Jun 14;8(6):e66381
pubmed: 23799095
Antioxid Redox Signal. 2010 Apr 1;12(7):819-27
pubmed: 19769463
Prog Neurobiol. 2016 Dec;147:1-19
pubmed: 27769868
Oxid Med Cell Longev. 2022 Jul 22;2022:6873874
pubmed: 35910833
Genet Mol Res. 2014 May 09;13(2):3586-98
pubmed: 24854439
Sci Adv. 2022 Jul 8;8(27):eabl8809
pubmed: 35857446
Brain Behav. 2020 May;10(5):e01602
pubmed: 32174034
J Ethnopharmacol. 1993 Mar;38(2-3):167-75
pubmed: 8510465
Acta Pharmacol Sin. 2021 Sep;42(9):1401-1408
pubmed: 33277592
Biology (Basel). 2022 Jan 28;11(2):
pubmed: 35205079
Neurochem Int. 2020 Feb;133:104586
pubmed: 31756514
Front Neurosci. 2016 Feb 09;10:31
pubmed: 26903798
Neurotherapeutics. 2011 Jul;8(3):515-25
pubmed: 21647765
Nat Med. 1996 Aug;2(8):864-70
pubmed: 8705854
J Clin Invest. 2013 Jan;123(1):224-35
pubmed: 23202730
Pharmacol Biochem Behav. 2013 May;106:57-67
pubmed: 23541491
Mol Brain. 2019 Sep 5;12(1):77
pubmed: 31488185
J Ginseng Res. 2021 Nov;45(6):665-675
pubmed: 34764721
J Chem Neuroanat. 2023 Apr;129:102248
pubmed: 36764334
Eur J Pharmacol. 2012 Jan 30;675(1-3):15-21
pubmed: 22166376
Antioxidants (Basel). 2021 Aug 26;10(9):
pubmed: 34572985
Int J Mol Sci. 2021 Mar 19;22(6):
pubmed: 33808629
Biol Pharm Bull. 2008 Jul;31(7):1392-6
pubmed: 18591781
J Agric Food Chem. 2019 Sep 11;67(36):10048-10058
pubmed: 31422666
Science. 1982 Jul 30;217(4558):408-14
pubmed: 7046051
Curr Vasc Pharmacol. 2017;15(6):549-556
pubmed: 28707603
Life Sci. 2017 Jan 1;168:16-23
pubmed: 27825720
Mol Med Rep. 2021 Apr;23(4):
pubmed: 33649817
Mini Rev Med Chem. 2022;22(22):2881-2895
pubmed: 35450523
J Agric Food Chem. 2005 Nov 2;53(22):8498-505
pubmed: 16248544
Neuroscience. 2019 Jul 15;411:86-104
pubmed: 31129202
J Alzheimers Dis. 2018;62(3):1403-1416
pubmed: 29036828
Pharmacol Res. 2018 Mar;129:262-273
pubmed: 29179999
Front Nutr. 2022 Apr 04;9:833859
pubmed: 35445056
Int J Mol Sci. 2022 Oct 27;23(21):
pubmed: 36361799
PLoS One. 2014 Jun 09;9(6):e96914
pubmed: 24911166
Am J Transl Res. 2019 May 15;11(5):2955-2968
pubmed: 31217866
Photochem Photobiol. 2019 Nov;95(6):1412-1423
pubmed: 31074886
J Asian Nat Prod Res. 2019 Aug;21(8):772-781
pubmed: 30501509
Int J Mol Sci. 2016 Jan 29;17(2):
pubmed: 26840295
Inflamm Regen. 2022 Oct 3;42(1):31
pubmed: 36184623
J Alzheimers Dis. 2018;62(3):1345-1367
pubmed: 29562527
Phytomedicine. 2019 Sep;62:152995
pubmed: 31271974
Neuromolecular Med. 2023 Jun;25(2):193-204
pubmed: 35948857
Traffic. 2023 Jan;24(1):20-33
pubmed: 36412210
Neurobiol Dis. 2013 Jun;54:320-8
pubmed: 23321003
Pharmacol Res. 2022 Mar;177:106099
pubmed: 35092819
Mol Biol Rep. 2019 Oct;46(5):5323-5332
pubmed: 31364016
Molecules. 2021 Aug 18;26(16):
pubmed: 34443587
Crit Rev Food Sci Nutr. 2019;59(18):2999-3018
pubmed: 29846084
Biochim Biophys Acta. 2014 Aug;1842(8):1240-7
pubmed: 24189435
Gen Psychiatr. 2022 Mar 11;35(1):e100751
pubmed: 35372787
Biol Pharm Bull. 2014;37(5):826-33
pubmed: 24599032
J Alzheimers Dis. 2017;57(4):1105-1121
pubmed: 28059794
Cells. 2019 Sep 19;8(9):
pubmed: 31546924
Biochem Biophys Res Commun. 2022 Jan 29;590:14-19
pubmed: 34968779
Aging (Albany NY). 2021 Mar 3;13(5):7549-7569
pubmed: 33686024
Trends Pharmacol Sci. 2008 Dec;29(12):609-15
pubmed: 18838179
Transl Neurodegener. 2020 Nov 26;9(1):42
pubmed: 33239064
Front Oncol. 2022 May 06;12:866154
pubmed: 35646647
J Pharmacol Exp Ther. 2012 Apr;341(1):59-67
pubmed: 22207656
PLoS One. 2022 Jul 8;17(7):e0271138
pubmed: 35802659
Front Pharmacol. 2021 Jan 14;11:570867
pubmed: 33597866
Neuroscientist. 2017 Apr;23(2):137-151
pubmed: 26908138
Front Aging Neurosci. 2022 Oct 14;14:1013295
pubmed: 36313020
Phytother Res. 2022 Apr;36(4):1523-1544
pubmed: 35084783
Life Sci. 2020 Oct 1;258:118107
pubmed: 32682919
J Ginseng Res. 2022 Jan;46(1):39-53
pubmed: 35058726
Eur J Pharmacol. 2021 Feb 15;893:173835
pubmed: 33359145
Antioxidants (Basel). 2016 Oct 25;5(4):
pubmed: 27792130
Int J Mol Sci. 2020 Nov 27;21(23):
pubmed: 33261147
Am J Transl Res. 2018 Mar 15;10(3):796-805
pubmed: 29636869
Pharmacol Res. 2019 Jan;139:512-523
pubmed: 30394318
Exp Ther Med. 2021 Aug;22(2):840
pubmed: 34149886
Biomed Pharmacother. 2022 Aug;152:113207
pubmed: 35667236
Nat Neurosci. 2008 May;11(5):547-54
pubmed: 18391946
Adv Exp Med Biol. 2018;1076:25-40
pubmed: 29951813
Food Funct. 2016 Nov 9;7(11):4506-4515
pubmed: 27801453
Biomolecules. 2020 Feb 28;10(3):
pubmed: 32121159
ACS Omega. 2021 Dec 06;6(49):33652-33664
pubmed: 34926913
Curr Alzheimer Res. 2012 Mar;9(3):388-95
pubmed: 22381145
Phytomedicine. 2021 Feb;82:153446
pubmed: 33387967
Cell Mol Neurobiol. 2012 Jan;32(1):121-8
pubmed: 21811848
Ann Med Interne (Paris). 1990;141 Suppl 1:13-8
pubmed: 2082781
BMC Complement Altern Med. 2012 Oct 26;12:196
pubmed: 23102375
Neurochem Int. 2021 Oct;149:105108
pubmed: 34175350
Zhen Ci Yan Jiu. 2022 Jul 25;47(7):573-9
pubmed: 35880272
Alzheimers Res Ther. 2018 Feb 13;10(1):18
pubmed: 29433569
Neurosci Biobehav Rev. 2022 Sep;140:104773
pubmed: 35811006
Curr Pharm Des. 2012;18(38):6339-47
pubmed: 22974003
Neural Regen Res. 2022 Nov;17(11):2342-2346
pubmed: 35535868
Int J Mol Sci. 2012;13(7):8562-8577
pubmed: 22942720
Front Cell Neurosci. 2022 Aug 16;16:980722
pubmed: 36052339
Proc Natl Acad Sci U S A. 2013 Nov 26;110(48):19567-72
pubmed: 24218590
J Cell Biochem. 2021 Nov;122(11):1594-1608
pubmed: 34494298
Mol Med Rep. 2022 Nov;26(5):
pubmed: 36052865
Front Neurol. 2020 Jan 10;10:1312
pubmed: 31998208
Trends Pharmacol Sci. 1991 Oct;12(10):383-8
pubmed: 1763432
Front Immunol. 2022 Jun 02;13:908076
pubmed: 35720333
Chem Biol Drug Des. 2022 Jun;99(6):884-896
pubmed: 35313087
Food Funct. 2018 Aug 15;9(8):4266-4273
pubmed: 30027191
Int J Mol Sci. 2022 Sep 02;23(17):
pubmed: 36077418
J Pharm Pharmacol. 2009 Mar;61(3):375-80
pubmed: 19222911
Chem Biol Interact. 2017 Sep 25;275:152-161
pubmed: 28756148
Complement Ther Med. 2020 Mar;49:102338
pubmed: 32147072
Cell Death Dis. 2011 Jun 02;2:e167
pubmed: 21633390
Front Pharmacol. 2022 Jul 07;13:946752
pubmed: 35873557
Brain Res. 2018 Jan 1;1678:187-194
pubmed: 29038007
J Mol Neurosci. 2019 Jan;67(1):62-71
pubmed: 30535776
J Mol Neurosci. 2015 Dec;57(4):522-8
pubmed: 26358038
Neurology. 1992 Sep;42(9):1681-8
pubmed: 1307688
Int J Alzheimers Dis. 2012;2012:489456
pubmed: 22666621
J Ginseng Res. 2016 Jan;40(1):9-17
pubmed: 26843817
J Ethnopharmacol. 2021 Feb 10;266:113466
pubmed: 33049344
Neurosci Lett. 2008 Mar 21;434(1):1-5
pubmed: 18313848
J Pharm Biomed Anal. 2014 Oct;99:8-15
pubmed: 25044150
Psychopharmacology (Berl). 2010 Oct;212(3):345-56
pubmed: 20676609
Trends Pharmacol Sci. 2002 Jun;23(6):288-93
pubmed: 12084635
Neurology. 1998 Jan;50(1):136-45
pubmed: 9443470
Artif Cells Blood Substit Immobil Biotechnol. 2012 Feb;40(1-2):142-5
pubmed: 22082349
Biomol Ther (Seoul). 2013 Sep 30;21(5):381-90
pubmed: 24244826
Phytother Res. 2021 Jan;35(1):337-345
pubmed: 32754961
Mol Neurodegener. 2018 Sep 26;13(1):50
pubmed: 30257685
Reprod Sci. 2021 Dec;28(12):3431-3439
pubmed: 34270001
Evid Based Complement Alternat Med. 2021 Dec 26;2021:4485957
pubmed: 34987593
Neurochem Res. 2012 Dec;37(12):2738-47
pubmed: 22903450