Phosphodiesterase 5 and Arginase Inhibitory Activities of the Extracts from Some Members of Nelumbonaceae and Nymphaeaceae Families.
Nymphaea pubescens
arginase
erectile dysfunction
flavonoids
lotus
phosphodiesterase 5
water lily
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
02 Aug 2023
02 Aug 2023
Historique:
received:
27
05
2023
revised:
22
07
2023
accepted:
28
07
2023
medline:
14
8
2023
pubmed:
12
8
2023
entrez:
12
8
2023
Statut:
epublish
Résumé
The objectives of this study were (1) to investigate the effect of extracts from some plants in the families Nelumbonaceae and Nymphaeaceae on phosphodiesterase 5 (PDE5) and arginase, which have been used in erectile dysfunction treatment, and (2) to isolate and identify the compounds responsible for such activities. The characterization and quantitative analysis of flavonoid constituents in the active extracts were performed by HPLC. Thirty-seven ethanolic extracts from different parts of plants in the genus
Identifiants
pubmed: 37570790
pii: molecules28155821
doi: 10.3390/molecules28155821
pmc: PMC10420992
pii:
doi:
Substances chimiques
Quercetin
9IKM0I5T1E
Cyclic Nucleotide Phosphodiesterases, Type 5
EC 3.1.4.35
Arginase
EC 3.5.3.1
Plant Extracts
0
Flavonoids
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : The Agricultural Research Development Agency (Public Organization)
ID : CRP6305030410
Organisme : The National Science, Research and Innovation Fund (NSRF) via the Program Management Unit for Human Resources & Institutional Development, Research and Innovation
ID : B16F640099
Références
Planta Med. 2018 Oct;84(15):1134-1140
pubmed: 29702722
BMC Complement Altern Med. 2017 Jan 17;17(1):52
pubmed: 28095910
Crit Rev Food Sci Nutr. 2019;59(sup1):S189-S209
pubmed: 30633540
J Ethnopharmacol. 2008 Sep 26;119(2):214-7
pubmed: 18582551
Sex Med Rev. 2020 Jan;8(1):48-58
pubmed: 31416758
J Clin Med. 2022 Oct 30;11(21):
pubmed: 36362656
J Pharm Pharmacol. 2015 Jan;67(1):87-95
pubmed: 25176340
Chem Biodivers. 2022 Jul;19(7):e202200121
pubmed: 35652145
Food Chem Toxicol. 2013 Sep;59:485-91
pubmed: 23827777
J Adv Pharm Technol Res. 2010 Jul;1(3):311-9
pubmed: 22247863
Biochem Biophys Rep. 2019 Aug 16;20:100678
pubmed: 31467991
Nat Prod Commun. 2015 Feb;10(2):301-3
pubmed: 25920267
Phytochem Anal. 2020 May;31(3):297-305
pubmed: 31777141
Phytother Res. 2010 Nov;24(11):1664-9
pubmed: 21031625
Molecules. 2010 Aug 31;15(9):5998-6007
pubmed: 20877205
Biochem Pharmacol. 2004 Nov 15;68(10):2087-94
pubmed: 15476679
Planta Med. 2003 Apr;69(4):310-5
pubmed: 12709896
Evid Based Complement Alternat Med. 2015;2015:789124
pubmed: 27057194
Exp Gerontol. 2019 Feb;116:54-73
pubmed: 30578842
Br J Pharmacol. 2012 Mar;165(5):1288-305
pubmed: 22014080
Plants (Basel). 2022 Oct 05;11(19):
pubmed: 36235488
J Urol. 2018 Sep;200(3):633-641
pubmed: 29746858
Cell Mol Life Sci. 1999 Jul;55(8-9):1015-28
pubmed: 10484661
J Ethnopharmacol. 2011 Oct 11;137(3):1437-41
pubmed: 21884777
Int J Impot Res. 2004 Jun;16 Suppl 1:S4-7
pubmed: 15224127
Biotechnol Lett. 2010 Apr;32(4):579-84
pubmed: 20033832
Chem Biodivers. 2018 Mar;15(3):e1700537
pubmed: 29325221
Planta Med. 2017 May;83(7):647-653
pubmed: 27776374
Asian J Androl. 2007 Nov;9(6):795-800
pubmed: 17968465
Int J Androl. 2000;23 Suppl 2:77-80
pubmed: 10849502
JAMA Netw Open. 2021 Feb 1;4(2):e2036337
pubmed: 33599772
Front Plant Sci. 2022 Jul 04;13:883151
pubmed: 35860537
J Ethnopharmacol. 2021 Mar 1;267:113536
pubmed: 33137431
Nat Prod Commun. 2017 Jan;12(1):79-82
pubmed: 30549830
Nat Rev Drug Discov. 2021 Mar;20(3):200-216
pubmed: 33510482