Research Progress on the Anti-Aging Potential of the Active Components of Ginseng.
DNA damage
DNA repair
aging
ginseng
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
25 Jul 2023
25 Jul 2023
Historique:
received:
26
06
2023
revised:
13
07
2023
accepted:
21
07
2023
medline:
14
8
2023
pubmed:
12
8
2023
entrez:
12
8
2023
Statut:
epublish
Résumé
Aging is a cellular state characterized by a permanent cessation of cell division and evasion of apoptosis. DNA damage, metabolic dysfunction, telomere damage, and mitochondrial dysfunction are the main factors associated with senescence. Aging increases β-galactosidase activity, enhances cell spreading, and induces Lamin B1 loss, which further accelerate the aging process. It is associated with a variety of diseases, such as Alzheimer's disease, Parkinson's, type 2 diabetes, and chronic inflammation. Ginseng is a traditional Chinese medicine with anti-aging effects. The active components of ginseng, including saponins, polysaccharides, and active peptides, have antioxidant, anti-apoptotic, neuroprotective, and age-delaying effects. DNA damage is the main factor associated with aging, and the mechanism through which the active ingredients of ginseng reduce DNA damage and delay aging has not been comprehensively described. This review focuses on the anti-aging mechanisms of the active ingredients of ginseng. Furthermore, it broadens the scope of ideas for further research on natural products and aging.
Identifiants
pubmed: 37571224
pii: nu15153286
doi: 10.3390/nu15153286
pmc: PMC10421173
pii:
doi:
Substances chimiques
Saponins
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : National Natural Science Foundation of China
ID : 31770948, 31570875, 81803547
Organisme : Natural Science Foundation of Fujian Province, China
ID : 2021J01204
Organisme : Fujian Provincial Regional Development Project
ID : 2021N3005
Organisme : Joint Funds for the Innovation of Science and Technology, Fujian Province
ID : 2018Y9011
Références
J Ginseng Res. 2017 Jul;41(3):277-283
pubmed: 28701867
Int J Biol Macromol. 2015 Apr;75:152-7
pubmed: 25616118
Pharm Biol. 2022 Dec;60(1):909-914
pubmed: 35575436
Cell Host Microbe. 2015 Jan 14;17(1):72-84
pubmed: 25532804
Aging Cell. 2020 May;19(5):e13145
pubmed: 32323422
Int J Mol Med. 2020 Apr;45(4):1225-1236
pubmed: 32124939
Biochim Biophys Acta Rev Cancer. 2021 Aug;1876(1):188556
pubmed: 33932560
Genes Dev. 2017 Jun 15;31(12):1180-1194
pubmed: 28765160
Nat Cell Biol. 2018 Dec;20(12):1338-1348
pubmed: 30482941
Int J Food Sci Nutr. 2015;66(7):815-8
pubmed: 26393910
Phytomedicine. 2022 Oct;105:154365
pubmed: 35930860
Cell. 2017 Jun 1;169(6):1000-1011
pubmed: 28575665
Carbohydr Polym. 2023 Jul 15;312:120818
pubmed: 37059546
Physiol Rev. 2018 Jul 1;98(3):1169-1203
pubmed: 29717933
Nat Rev Endocrinol. 2020 May;16(5):263-275
pubmed: 32161396
Evid Based Complement Alternat Med. 2020 Jul 11;2020:6065124
pubmed: 32733585
Cell. 2019 Oct 31;179(4):813-827
pubmed: 31675495
Neural Regen Res. 2020 May;15(5):887-893
pubmed: 31719254
J Biochem Mol Toxicol. 2022 Jan;36(1):e22885
pubmed: 34859534
Clin Exp Dermatol. 2007 Nov;32(6):722-7
pubmed: 17953641
Int J Biol Macromol. 2019 Jul 15;133:324-336
pubmed: 30943421
Int J Oncol. 2019 Jun;54(6):2069-2079
pubmed: 31081060
Photochem Photobiol. 2018 Sep;94(5):1040-1048
pubmed: 29779217
Int J Biol Macromol. 2019 Mar 1;124:931-937
pubmed: 30503788
J Ethnopharmacol. 2023 Feb 10;302(Pt A):115883
pubmed: 36328205
Aging Cell. 2019 Jun;18(3):e12946
pubmed: 30916891
J Ginseng Res. 2021 Mar;45(2):344-353
pubmed: 33841015
J Ginseng Res. 2017 Jul;41(3):268-276
pubmed: 28701866
Cell Rep. 2017 Mar 21;18(12):2880-2892
pubmed: 28329681
Free Radic Biol Med. 2021 Oct;174:182-194
pubmed: 34364981
Food Funct. 2021 Sep 7;12(17):8068-8077
pubmed: 34286798
Phytomedicine. 2021 Jun;86:153563
pubmed: 33951569
Theranostics. 2021 Jan 1;11(1):222-256
pubmed: 33391472
Trends Mol Med. 2020 Feb;26(2):185-200
pubmed: 31679988
J Mol Biol. 2020 Jan 3;432(1):3-27
pubmed: 31082435
Nature. 2021 Apr;592(7856):695-703
pubmed: 33911272
Mol Neurobiol. 2019 May;56(5):3280-3294
pubmed: 30117105
J Mol Med (Berl). 2018 Nov;96(11):1153-1166
pubmed: 30229272
Biogerontology. 2022 Aug;23(4):485-497
pubmed: 35939242
Redox Biol. 2019 Jul;25:101084
pubmed: 30612957
Cells. 2020 Jul 10;9(7):
pubmed: 32664329
J Biol Chem. 2015 Oct 9;290(41):24636-48
pubmed: 26245904
Front Cell Neurosci. 2018 Jul 10;12:169
pubmed: 30050410
Leukemia. 2019 Oct;33(10):2365-2378
pubmed: 30940905
N Engl J Med. 2017 Nov 9;377(19):1868-1876
pubmed: 29117491
Elife. 2021 Jan 13;10:
pubmed: 33438577
Ageing Res Rev. 2021 Dec;72:101468
pubmed: 34563704
Oxid Med Cell Longev. 2022 Apr 20;2022:9299574
pubmed: 35498130
EMBO J. 2019 Oct 4;38(21):e102718
pubmed: 31544964
J Ginseng Res. 2020 Jan;44(1):79-85
pubmed: 32148392
Biosci Biotechnol Biochem. 2015;80(1):95-103
pubmed: 26287932
Biomed Pharmacother. 2020 Dec;132:110915
pubmed: 33254433
Nat Rev Neurosci. 2015 Nov;16(11):672-84
pubmed: 26462757
Cell. 2017 Feb 9;168(4):644-656
pubmed: 28187286
Chin Med J (Engl). 2021 May 13;135(1):107-109
pubmed: 33989229
Phytother Res. 2019 Apr;33(4):1095-1103
pubmed: 30740801
Aging (Albany NY). 2019 Apr 19;11(8):2378-2387
pubmed: 31002655
Ageing Res Rev. 2020 Dec;64:101156
pubmed: 32949770
Cell Death Dis. 2020 Jun 12;11(6):454
pubmed: 32532964
Ageing Res Rev. 2021 Jul;68:101323
pubmed: 33771720
Gut. 2022 Apr;71(4):734-745
pubmed: 34006584
Cell Signal. 2017 Dec;40:99-115
pubmed: 28911859
Molecules. 2020 Mar 02;25(5):
pubmed: 32121640
Nat Cell Biol. 2018 Mar;20(3):233-242
pubmed: 29476151
Int J Mol Sci. 2019 Apr 29;20(9):
pubmed: 31036793
Mol Neurobiol. 2018 Jul;55(7):6076-6093
pubmed: 29170981
Nat Rev Mol Cell Biol. 2017 Aug;18(8):495-506
pubmed: 28512351
Cell. 2019 Jun 13;177(7):1682-1699
pubmed: 31199916
Science. 2011 Jun 17;332(6036):1443-6
pubmed: 21680843
Phytomedicine. 2022 Sep;104:154341
pubmed: 35870376
Neurochem Res. 2018 Feb;43(2):430-440
pubmed: 29147958
J Ginseng Res. 2015 Jul;39(3):250-6
pubmed: 26199557
J Ginseng Res. 2015 Jul;39(3):238-42
pubmed: 26199555
Am J Chin Med. 2019;47(4):823-839
pubmed: 31091972
J Ginseng Res. 2017 Apr;41(2):127-133
pubmed: 28413316
Mol Med Rep. 2019 Feb;19(2):783-791
pubmed: 30535469
Nature. 2009 Oct 22;461(7267):1071-8
pubmed: 19847258
Tumour Biol. 2015 Apr;36(4):2377-81
pubmed: 25416441
Radiother Oncol. 2013 Sep;108(3):362-9
pubmed: 23849169
J Ginseng Res. 2020 Mar;44(2):341-349
pubmed: 32148417
Photochem Photobiol. 2020 Jan;96(1):113-123
pubmed: 31441061
J Agric Food Chem. 2022 Nov 9;70(44):14220-14234
pubmed: 36300841
Food Funct. 2021 Aug 2;12(15):6793-6808
pubmed: 34109970
Genes Dev. 2017 Dec 1;31(23-24):2325-2330
pubmed: 29321179
Mol Med Rep. 2018 May;17(5):6269-6276
pubmed: 29512726
EMBO Mol Med. 2019 Dec;11(12):e10234
pubmed: 31746100
Cell Prolif. 2018 Jun;51(3):e12438
pubmed: 29457293
Am J Pathol. 2009 Jan;174(1):101-14
pubmed: 19116368
Biomed Pharmacother. 2022 Dec;156:113912
pubmed: 36288668
J Cell Biol. 2018 Jan 2;217(1):65-77
pubmed: 29114066
Nat Commun. 2020 May 18;11(1):2484
pubmed: 32424276
J Am Soc Nephrol. 2018 Jul;29(7):1799-1809
pubmed: 29712732
J Ginseng Res. 2017 Jan;41(1):69-77
pubmed: 28123324
Cold Spring Harb Perspect Biol. 2013 Feb 01;5(2):
pubmed: 23378590
Photochem Photobiol. 2019 Nov;95(6):1412-1423
pubmed: 31074886
J Nat Prod. 2020 Apr 24;83(4):918-926
pubmed: 32129622
Free Radic Biol Med. 2022 Aug 20;189:2-19
pubmed: 35840016
J Cell Mol Med. 2020 Mar;24(6):3751-3755
pubmed: 32022406
Front Cell Dev Biol. 2019 Jul 30;7:143
pubmed: 31417903
Int J Mol Sci. 2016 Feb 18;17(2):160
pubmed: 26901191
J Ginseng Res. 2022 Sep;46(5):657-665
pubmed: 36090680
Eur J Pharmacol. 2022 Feb 15;917:174742
pubmed: 34999087
Aging Cell. 2019 Feb;18(1):e12858
pubmed: 30548445
Nucleic Acids Res. 2015 Jan;43(2):943-59
pubmed: 25552414
Food Funct. 2021 Apr 7;12(7):2874-2885
pubmed: 33877243
J Ginseng Res. 2016 Apr;40(2):113-20
pubmed: 27158231
Cold Spring Harb Perspect Biol. 2013 Apr 01;5(4):a012583
pubmed: 23545420
Photodermatol Photoimmunol Photomed. 2017 Nov;33(6):311-320
pubmed: 28793178
Science. 2013 Feb 15;339(6121):786-91
pubmed: 23258413
Nutrients. 2022 Dec 12;14(24):
pubmed: 36558448
Cell Rep. 2022 Mar 1;38(9):110444
pubmed: 35235784
J Alzheimers Dis. 2012;31(1):207-23
pubmed: 22543851
Mutat Res Rev Mutat Res. 2018 Jan - Mar;775:21-38
pubmed: 29555027
Eur J Pharmacol. 2020 Jan 5;866:172801
pubmed: 31738935
Int J Biol Macromol. 2019 Apr 1;126:842-845
pubmed: 30610944
Haematologica. 2018 Jan;103(1):80-90
pubmed: 29025907
Nature. 2022 Jun;606(7916):930-936
pubmed: 35477155
J Ginseng Res. 2020 Jul;44(4):527-537
pubmed: 32617032
Int J Mol Sci. 2021 Dec 06;22(23):
pubmed: 34884975
Int J Mol Sci. 2020 Feb 07;21(3):
pubmed: 32046099
Pharmacol Rev. 2022 Jul;74(3):712-768
pubmed: 35738680
Am J Chin Med. 2016;44(3):595-615
pubmed: 27109153
J Ginseng Res. 2023 Mar;47(2):337-346
pubmed: 36926607
Neuropharmacology. 2016 Feb;101:480-9
pubmed: 26525190
Nature. 2018 Nov;563(7729):131-136
pubmed: 30356214
Int J Mol Sci. 2022 Jun 24;23(13):
pubmed: 35806061
Ageing Res Rev. 2020 Jan;57:101000
pubmed: 31862417
Mol Cell. 2010 Oct 22;40(2):179-204
pubmed: 20965415
Nat Neurosci. 2019 May;22(5):719-728
pubmed: 30936558
J Ethnopharmacol. 2020 Jun 12;255:112746
pubmed: 32165173
Brain Behav Immun. 2021 May;94:410-423
pubmed: 33662500
Gerontology. 2015;61(6):515-25
pubmed: 25832544
Mutat Res. 2012 Oct-Dec;751(2):158-246
pubmed: 22743550
Int Immunopharmacol. 2018 May;58:94-102
pubmed: 29567591
Antioxid Redox Signal. 2017 Dec 20;27(18):1447-1459
pubmed: 28494652
Gerontology. 2018;64(6):562-575
pubmed: 30138913
J Microbiol Biotechnol. 2015 Dec 28;25(12):2011-5
pubmed: 26437949
Food Res Int. 2022 Sep;159:111610
pubmed: 35940805
Oxid Med Cell Longev. 2017;2017:6313625
pubmed: 29430282
Acta Pharmacol Sin. 2019 Jan;40(1):13-25
pubmed: 30262824
Sci Rep. 2018 Sep 17;8(1):13902
pubmed: 30224635
Aging (Albany NY). 2019 Aug 10;11(15):5548-5569
pubmed: 31400753
J Ginseng Res. 2021 Jan;45(1):183-190
pubmed: 33437170
Mol Cell. 2018 Sep 6;71(5):745-760.e5
pubmed: 30193098
Int J Mol Sci. 2016 Jun 09;17(6):
pubmed: 27294914
Environ Mol Mutagen. 2017 Jun;58(5):235-263
pubmed: 28485537
J Ginseng Res. 2021 May;45(3):363-370
pubmed: 34025129
Nat Rev Rheumatol. 2023 Apr;19(4):200-211
pubmed: 36750681
Chem Biol Drug Des. 2022 Jun;99(6):884-896
pubmed: 35313087
J Med Food. 2018 Sep;21(9):849-857
pubmed: 30136914
Trends Mol Med. 2020 Jul;26(7):630-638
pubmed: 32589933
J Ginseng Res. 2018 Jul;42(3):389-399
pubmed: 29983620
Biol Pharm Bull. 2019;42(9):1510-1516
pubmed: 31474711
Antioxidants (Basel). 2021 Jan 06;10(1):
pubmed: 33419084
Cold Spring Harb Perspect Med. 2016 Mar 01;6(3):a026104
pubmed: 26931810
J Ginseng Res. 2018 Oct;42(4):532-539
pubmed: 30337814
Plant Foods Hum Nutr. 2023 Jun;78(2):320-328
pubmed: 36947370
Clin Cancer Res. 2007 Jul 15;13(14):4042-5
pubmed: 17634527
Chin Med J (Engl). 2016 Aug 20;129(16):1955-62
pubmed: 27503022
J Clin Invest. 2018 Apr 2;128(4):1238-1246
pubmed: 29608137
J Ginseng Res. 2022 Jul;46(4):536-542
pubmed: 35818428
Nat Rev Mol Cell Biol. 2021 Feb;22(2):75-95
pubmed: 33328614
J Sep Sci. 2008 Oct;31(19):3451-7
pubmed: 18803254
J Ginseng Res. 2021 Nov;45(6):717-725
pubmed: 34764726
Ageing Res Rev. 2009 Jan;8(1):43-51
pubmed: 19022406
Drug Des Devel Ther. 2020 Feb 05;14:527-538
pubmed: 32103895
Front Aging Neurosci. 2022 Jun 17;14:870326
pubmed: 35795238
Int J Biol Macromol. 2017 Oct;103:1327-1333
pubmed: 28522391
Biology (Basel). 2022 Jul 25;11(8):
pubmed: 35892965
Elife. 2021 Jan 29;10:
pubmed: 33512317
Exp Gerontol. 2018 May;105:10-18
pubmed: 29275161