Cafeteria Diet-Induced Obesity Worsens Experimental CKD.


Journal

Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595

Informations de publication

Date de publication:
26 Jul 2023
Historique:
received: 30 06 2023
revised: 20 07 2023
accepted: 21 07 2023
medline: 14 8 2023
pubmed: 12 8 2023
entrez: 12 8 2023
Statut: epublish

Résumé

Obesity is a significant risk factor for chronic kidney disease (CKD). This study aimed to evaluate the impact of obesity on the development of kidney fibrosis in a model of cafeteria diet rats undergoing 5/6th nephrectomy (SNx). Collagen 1, 3, and 4 expression, adipocyte size, macrophage number, and the expression of 30 adipokines were determined. Collagen 1 expression in kidney tissue was increased in Standard-SNx and Cafeteria-SNx (7.1 ± 0.6% and 8.9 ± 0.9 tissue area, respectively). Renal expression of collagen 3 and 4 was significantly increased (

Identifiants

pubmed: 37571269
pii: nu15153331
doi: 10.3390/nu15153331
pmc: PMC10421241
pii:
doi:

Substances chimiques

Serpins 0
Collagen 9007-34-5

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

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Auteurs

Jonas Laget (J)

RD-Néphrologie, 34090 Montpellier, France.

Irene Cortijo (I)

RD-Néphrologie, 34090 Montpellier, France.

Juliana H Boukhaled (JH)

RD-Néphrologie, 34090 Montpellier, France.

Karen Muyor (K)

RD-Néphrologie, 34090 Montpellier, France.

Flore Duranton (F)

RD-Néphrologie, 34090 Montpellier, France.

Bernard Jover (B)

RD-Néphrologie, 34090 Montpellier, France.

Fabrice Raynaud (F)

PhyMedExp, INSERM, CNRS, Université de Montpellier, 34090 Montpellier, France.

Anne-Dominique Lajoix (AD)

Biocommunication in Cardio-Metabolism (BC2M), University of Montpellier, 34090 Montpellier, France.

Àngel Argilés (À)

RD-Néphrologie, 34090 Montpellier, France.

Nathalie Gayrard (N)

RD-Néphrologie, 34090 Montpellier, France.

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Classifications MeSH