Combined proteomics and transcriptomics identifies serpin family C member 1 associated protein as a biomarker of endometriosis.
Endometriosis
FETUB
coagulation and inflammation
serpins
Journal
Annals of medicine
ISSN: 1365-2060
Titre abrégé: Ann Med
Pays: England
ID NLM: 8906388
Informations de publication
Date de publication:
2023
2023
Historique:
medline:
14
8
2023
pubmed:
13
8
2023
entrez:
12
8
2023
Statut:
ppublish
Résumé
To explore potential biomarkers indicating endometriosis (EM). A proteomics method and combined quantitative transcriptomics were adopted to highlight markers in the EM. Venn analysis was used to integrate the ribonucleic acid sequencing (RNA-seq) and protein profiles. Promising candidate markers were tested by enzyme-related immunosorbent assay. A sum of 979 mRNAs and 39 proteins were tested to be significantly differentially expression in the standard cluster compared with the EM cluster. Venn analysis showed a filtered signature of only two down-regulated molecules in the EM group, i.e. fetuin B (FETUB) and serpin family C member 1 (SERPINC1); the latter showed a big variance between the control category and the EM set in the authentication test. SERPINC1 may be a useful possible biomarker for the analysis of EM.
Identifiants
pubmed: 37572646
doi: 10.1080/07853890.2023.2243825
pmc: PMC10424617
doi:
Substances chimiques
Serpins
0
Biomarkers
0
Banques de données
ClinicalTrials.gov
['NCT03682341']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2243825Références
J Proteome Res. 2010 Jul 2;9(7):3621-37
pubmed: 20450226
Int J Oncol. 2015 May;46(5):2125-37
pubmed: 25695231
Med Sci Monit. 2009 May;15(5):RA116-23
pubmed: 19396052
Int J Clin Exp Med. 2015 Apr 15;8(4):5010-21
pubmed: 26131074
Cochrane Database Syst Rev. 2016 May 01;(5):CD012179
pubmed: 27132058
Front Immunol. 2018 Apr 12;9:761
pubmed: 29706968
Lancet. 2021 Feb 27;397(10276):839-852
pubmed: 33640070
Chem Rev. 2002 Dec;102(12):4751-804
pubmed: 12475206
Neuroscience. 2018 Oct 15;390:231-240
pubmed: 30193860
Obstet Gynecol. 2012 Feb;119(2 Pt 1):276-85
pubmed: 22270279
Hum Reprod Update. 2011 Sep-Oct;17(5):637-53
pubmed: 21672902
Reprod Sci. 2011 Mar;18(3):229-51
pubmed: 21063030
Cytogenet Cell Genet. 1985;39(1):67-9
pubmed: 3979120
Dev Cell. 2013 Apr 15;25(1):106-12
pubmed: 23562279
Lancet. 2004 Nov 13-19;364(9447):1789-99
pubmed: 15541453
J Immunol Res. 2023 Apr 19;2023:6455704
pubmed: 37124547
Fertil Steril. 2011 Mar 1;95(3):882-8.e1
pubmed: 21055747
Epigenomics. 2019 Feb;11(2):147-167
pubmed: 30638056
Reprod Biol Endocrinol. 2018 Oct 15;16(1):96
pubmed: 30322386
Hum Reprod. 2012 Jul;27(7):2020-9
pubmed: 22556377
Nat Rev Drug Discov. 2003 Feb;2(2):140-50
pubmed: 12563305
Hum Reprod Update. 2007 Jul-Aug;13(4):395-404
pubmed: 17584822
Int J Mol Sci. 2020 Mar 04;21(5):
pubmed: 32143439
Br J Haematol. 2017 Jul;178(2):279-285
pubmed: 28317092
Cell. 2021 May 27;184(11):2807-2824
pubmed: 34048704
CNS Neurosci Ther. 2023 Jul;29(7):1738-1749
pubmed: 37017398
Proteomics Clin Appl. 2014 Feb;8(1-2):86-98
pubmed: 23894130
Cell. 2011 Aug 5;146(3):353-8
pubmed: 21802130
J Cell Biol. 2012 Apr 2;197(1):37-44
pubmed: 22472438
Dev Biol. 2012 Mar 1;363(1):40-51
pubmed: 22206759
EMBO Mol Med. 2015 Jun 18;7(8):996-1003
pubmed: 26089099
Gynecol Obstet Invest. 2016;81(4):321-4
pubmed: 26742108
Hum Reprod Update. 2010 Nov-Dec;16(6):651-74
pubmed: 20462942
J Obstet Gynaecol Res. 2017 Oct;43(10):1563-1569
pubmed: 28707780
Biol Chem. 2014 Oct;395(10):1195-9
pubmed: 25205729
Mol Hum Reprod. 2007 Aug;13(8):527-35
pubmed: 17557764
Fertil Steril. 2013 Mar 15;99(4):1135-45
pubmed: 23414923