Loss of CD4
IFN-γ
IL-10
Th1 immunity
arginase 1
arginase 1 deficiency
autoimmunity
cell metabolism
complement
glutamine
influenza infection
Journal
Immunity
ISSN: 1097-4180
Titre abrégé: Immunity
Pays: United States
ID NLM: 9432918
Informations de publication
Date de publication:
12 09 2023
12 09 2023
Historique:
received:
14
10
2022
revised:
01
06
2023
accepted:
19
07
2023
medline:
15
9
2023
pubmed:
13
8
2023
entrez:
12
8
2023
Statut:
ppublish
Résumé
Arginase 1 (Arg1), the enzyme catalyzing the conversion of arginine to ornithine, is a hallmark of IL-10-producing immunoregulatory M2 macrophages. However, its expression in T cells is disputed. Here, we demonstrate that induction of Arg1 expression is a key feature of lung CD4
Identifiants
pubmed: 37572656
pii: S1074-7613(23)00327-8
doi: 10.1016/j.immuni.2023.07.014
pmc: PMC10576612
mid: NIHMS1923920
pii:
doi:
Substances chimiques
Arginase
EC 3.5.3.1
Glutamine
0RH81L854J
Arg1 protein, mouse
EC 3.5.3.1
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, N.I.H., Intramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
2036-2053.e12Subventions
Organisme : NHLBI NIH HHS
ID : K22 HL125593
Pays : United States
Organisme : Intramural NIH HHS
ID : Z99 HL999999
Pays : United States
Organisme : Intramural NIH HHS
ID : ZIA DK075149
Pays : United States
Organisme : Intramural NIH HHS
ID : ZIA HL006223
Pays : United States
Informations de copyright
Published by Elsevier Inc.
Déclaration de conflit d'intérêts
Declaration of interests M.S. is an inventor on a patent describing the use of RBD ligands for cell-surface evaluation of CAT1/solute carrier family 7 member 1 (SLC7A1) and other solute carrier (SLC) expression (N.T. gave up her rights); he is a co-founder and head of the scientific board of METAFORA-Biosystems, a start-up company that focuses on metabolite transporters under physiological and pathological conditions.
Références
J Immunol. 2002 May 15;168(10):4827-31
pubmed: 11994430
J Immunol. 2010 Aug 15;185(4):2182-90
pubmed: 20639484
Methods Enzymol. 2014;542:369-89
pubmed: 24862276
J Exp Med. 2004 Nov 15;200(10):1289-97
pubmed: 15534372
Amino Acids. 2014 May;46(5):1253-63
pubmed: 24515597
Immunity. 2020 Mar 17;52(3):513-527.e8
pubmed: 32187519
Semin Immunol. 2019 Aug;44:101344
pubmed: 31727465
Stem Cells. 2002;20(3):241-8
pubmed: 12004082
Antiviral Res. 2013 Sep;99(3):230-7
pubmed: 23721943
Biochemistry. 2013 Jun 4;52(22):3829-40
pubmed: 23442130
J Mol Med (Berl). 2015 Dec;93(12):1287-96
pubmed: 26467175
JCI Insight. 2019 Dec 19;4(24):
pubmed: 31852848
Cell. 2021 Aug 5;184(16):4186-4202.e20
pubmed: 34216540
Blood. 2001 Nov 15;98(10):3143-9
pubmed: 11698303
Nat Immunol. 2022 Jan;23(1):62-74
pubmed: 34764490
Cell. 2016 Oct 20;167(3):829-842.e13
pubmed: 27745970
Cell Mol Gastroenterol Hepatol. 2015 Mar 1;1(2):154-170
pubmed: 26000334
Metabolomics. 2007 Sep;3(3):211-221
pubmed: 24039616
Int J Mol Sci. 2020 Jul 25;21(15):
pubmed: 32722521
Nat Commun. 2021 Mar 5;12(1):1460
pubmed: 33674584
J Exp Med. 1994 Feb 1;179(2):589-600
pubmed: 7905019
Cell. 2018 Dec 13;175(7):1780-1795.e19
pubmed: 30392958
Immunity. 2018 Dec 18;49(6):1004-1019
pubmed: 30566879
J Immunol. 2011 Dec 1;187(11):5568-76
pubmed: 22043009
J Exp Med. 2001 Nov 19;194(10):1497-506
pubmed: 11714756
Nat Med. 2009 Mar;15(3):277-84
pubmed: 19234462
Nat Immunol. 2012 Dec;13(12):1213-21
pubmed: 23086448
Nucleic Acids Res. 2015 Apr 20;43(7):e47
pubmed: 25605792
Cell Mol Immunol. 2020 Sep;17(9):1010-1013
pubmed: 31974397
Int Rev Cell Mol Biol. 2018;341:125-168
pubmed: 30262031
Immunopharmacology. 1991 Mar-Apr;21(2):129-43
pubmed: 1831810
FEBS Lett. 1973 Feb 1;29(3):301-304
pubmed: 11946938
Immunity. 1994 Oct;1(7):553-62
pubmed: 7600284
Int J Cancer. 2021 Apr 15;148(8):1993-2009
pubmed: 33368291
J Immunol. 1996 Jul 15;157(2):798-805
pubmed: 8752931
J Virol. 2014 Aug;88(16):9010-6
pubmed: 24899187
Oncogene. 2019 Jun;38(24):4729-4738
pubmed: 30765862
Immunity. 2015 Jun 16;42(6):1033-47
pubmed: 26084023
Front Immunol. 2019 Oct 02;10:2351
pubmed: 31632414
Cell Immunol. 1987 May;106(2):420-7
pubmed: 3105898
Annu Rev Immunol. 2018 Apr 26;36:309-338
pubmed: 29677470
Cancer Lett. 2021 Apr 1;502:180-188
pubmed: 33450358
Crit Rev Immunol. 2012;32(6):463-88
pubmed: 23428224
Met Ions Biol Syst. 2000;37:407-28
pubmed: 10693141
JCI Insight. 2019 Nov 21;4(24):
pubmed: 31751318
Nat Commun. 2019 Jan 30;10(1):498
pubmed: 30700717
Trends Cancer. 2021 Aug;7(8):790-804
pubmed: 34020912
PLoS Pathog. 2010 Jun 17;6(6):e1000899
pubmed: 20585552
Cell Syst. 2015 Dec 23;1(6):417-425
pubmed: 26771021
Nat Med. 2006 Nov;12(11):1301-9
pubmed: 17041596
Bioinformatics. 2010 Jan 1;26(1):139-40
pubmed: 19910308
Nucleic Acids Res. 2019 May 7;47(8):e47
pubmed: 30783653
Mol Cell Biol. 2001 Feb;21(3):811-3
pubmed: 11154268
Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15545-50
pubmed: 16199517
Nat Methods. 2012 Mar 04;9(4):357-9
pubmed: 22388286
J Immunol. 2000 Feb 15;164(4):1839-46
pubmed: 10657632
Cell. 2013 Jun 6;153(6):1239-51
pubmed: 23746840
Front Immunol. 2014 Oct 27;5:533
pubmed: 25386179
Physiol Rev. 2018 Apr 1;98(2):641-665
pubmed: 29412048
J Exp Med. 2007 Feb 19;204(2):239-43
pubmed: 17296790
Sci Rep. 2018 Feb 27;8(1):3697
pubmed: 29487337
Sci Signal. 2015 Sep 29;8(396):ra97
pubmed: 26420908
J Infect Dis. 2018 Aug 24;218(7):1169-1174
pubmed: 29762692
Nat Immunol. 2008 Dec;9(12):1399-406
pubmed: 18978793
J Immunol. 1997 Mar 1;158(5):2259-67
pubmed: 9036973
Immunity. 2001 Nov;15(5):763-74
pubmed: 11728338
Curr Top Med Chem. 2018;18(6):432-443
pubmed: 29793408
Cancers (Basel). 2022 Jan 22;14(3):
pubmed: 35158820
J Immunol. 2008 Jul 15;181(2):891-8
pubmed: 18606640
Eur J Immunol. 1985 Aug;15(8):783-7
pubmed: 3875490
Exp Mol Med. 2020 Sep;52(9):1496-1516
pubmed: 32943735
Vaccine. 2017 Jul 24;35(33):4255-4261
pubmed: 28662951
J Immunol. 2009 Dec 15;183(12):7672-81
pubmed: 19933864
Immunity. 2011 Dec 23;35(6):871-82
pubmed: 22195744
Front Immunol. 2014 Jul 14;5:331
pubmed: 25071787
Nat Immunol. 2010 Sep;11(9):862-71
pubmed: 20694009
Mucosal Immunol. 2010 May;3(3):239-46
pubmed: 20200511
Eur J Immunol. 2016 Jan;46(1):92-103
pubmed: 26449889
Nat Biotechnol. 2016 Aug 9;34(8):794-5
pubmed: 27504761
Cell Rep. 2021 Nov 2;37(5):109911
pubmed: 34731632
Front Immunol. 2020 May 15;11:938
pubmed: 32499785