Hippocampal sharp-wave ripples and their spike assembly content are regulated by the medial entorhinal cortex.
CA1
DOWN states
assemblies
entorhinal cortex
hippocampus
neocortical sleep states
sharp-wave ripples
Journal
Current biology : CB
ISSN: 1879-0445
Titre abrégé: Curr Biol
Pays: England
ID NLM: 9107782
Informations de publication
Date de publication:
11 09 2023
11 09 2023
Historique:
received:
11
04
2023
revised:
18
07
2023
accepted:
20
07
2023
pmc-release:
11
09
2024
medline:
14
9
2023
pubmed:
13
8
2023
entrez:
12
8
2023
Statut:
ppublish
Résumé
Hippocampal sharp-wave ripples (SPW-Rs) are critical for memory consolidation and retrieval. The neuronal content of spiking during SPW-Rs is believed to be under the influence of neocortical inputs via the entorhinal cortex (EC). Optogenetic silencing of the medial EC (mEC) reduced the incidence of SPW-Rs with minor impacts on their magnitude or duration, similar to local CA1 silencing. The effect of mEC silencing on CA1 firing and field potentials was comparable to the effect of transient cortex-wide DOWN states of non-REM (NREM) sleep, implying that decreased SPW-R incidence in both cases is due to tonic disfacilitation of hippocampal circuits. The neuronal composition of CA1 pyramidal neurons during SPW-Rs was altered by mEC silencing but was restored immediately after silencing. We suggest that the mEC provides both tonic and transient influences on hippocampal network states by timing the occurrence of SPW-Rs and altering their neuronal content.
Identifiants
pubmed: 37572665
pii: S0960-9822(23)00978-8
doi: 10.1016/j.cub.2023.07.039
pmc: PMC10530523
mid: NIHMS1923922
pii:
doi:
Types de publication
Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3648-3659.e4Subventions
Organisme : NIMH NIH HHS
ID : R01 MH122391
Pays : United States
Organisme : NINDS NIH HHS
ID : U19 NS104590
Pays : United States
Organisme : NINDS NIH HHS
ID : U19 NS107616
Pays : United States
Informations de copyright
Copyright © 2023 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests The authors declare no competing interests.
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