Mitochondria-targeted melatonin photorelease supports the presence of melatonin MT1 receptors in mitochondria inhibiting respiration.

Animals Humans Mice Receptor, Melatonin, MT1 / metabolism Melatonin / pharmacology HEK293 Cells Receptors, G-Protein-Coupled / metabolism Mitochondria / metabolism Respiration
G protein-coupled receptors intracellular signaling melatonin melatonin receptors mitochondria mitochondria-targeted caged melatonin ligand mitochondrial respiration photopharmacology

Journal

Cell chemical biology
ISSN: 2451-9448
Titre abrégé: Cell Chem Biol
Pays: United States
ID NLM: 101676030

Informations de publication

Date de publication:
17 08 2023
Historique:
received: 25 08 2022
revised: 16 04 2023
accepted: 20 07 2023
medline: 22 8 2023
pubmed: 13 8 2023
entrez: 12 8 2023
Statut: ppublish

Résumé

The presence of signaling-competent G protein-coupled receptors in intracellular compartments is increasingly recognized. Recently, the presence of G

Identifiants

DOI: 10.1016/j.chembiol.2023.07.009 PMID: 37572668
pubmed: 37572668
pii: S2451-9456(23)00237-4
doi: 10.1016/j.chembiol.2023.07.009
pii:
doi:

Substances chimiques

Receptor, Melatonin, MT1 0
Melatonin JL5DK93RCL
Receptors, G-Protein-Coupled 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

920-932.e7

Informations de copyright

Copyright © 2023 Elsevier Ltd. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests The authors declare no competing interest.

Auteurs

Gloria Somalo-Barranco (G)

Université Paris Cité, Institut Cochin, INSERM, CNRS, 75014 PARIS, France; MCS, Laboratory of Medicinal Chemistry & Synthesis, Department of Biological Chemistry, Institute for Advanced Chemistry of Catalonia (IQAC-CSIC), Barcelona, Spain.

Antonio C Pagano Zottola (AC)

INSERM, U1215 NeuroCentre Magendie, Endocannabinoids and Neuroadaptation, Bordeaux, France.

Abdulrasheed O Abdulrahman (AO)

Université Paris Cité, Institut Cochin, INSERM, CNRS, 75014 PARIS, France.

Rami M El Zein (RM)

Université Paris Cité, Institut Cochin, INSERM, CNRS, 75014 PARIS, France.

Astrid Cannich (A)

INSERM, U1215 NeuroCentre Magendie, Endocannabinoids and Neuroadaptation, Bordeaux, France.

Lourdes Muñoz (L)

MCS, Laboratory of Medicinal Chemistry & Synthesis, Department of Biological Chemistry, Institute for Advanced Chemistry of Catalonia (IQAC-CSIC), Barcelona, Spain; SIMChem, Synthesis of High Added Value Molecules, Institute of Advanced Chemistry of Catalonia (IQAC-CSIC), Barcelona, Spain.

Carme Serra (C)

MCS, Laboratory of Medicinal Chemistry & Synthesis, Department of Biological Chemistry, Institute for Advanced Chemistry of Catalonia (IQAC-CSIC), Barcelona, Spain; SIMChem, Synthesis of High Added Value Molecules, Institute of Advanced Chemistry of Catalonia (IQAC-CSIC), Barcelona, Spain.

Atsuro Oishi (A)

Université Paris Cité, Institut Cochin, INSERM, CNRS, 75014 PARIS, France.

Giovanni Marsicano (G)

INSERM, U1215 NeuroCentre Magendie, Endocannabinoids and Neuroadaptation, Bordeaux, France.

Bernard Masri (B)

Université Paris Cité, Institut Cochin, INSERM, CNRS, 75014 PARIS, France.

Luigi Bellocchio (L)

INSERM, U1215 NeuroCentre Magendie, Endocannabinoids and Neuroadaptation, Bordeaux, France.

Amadeu Llebaria (A)

MCS, Laboratory of Medicinal Chemistry & Synthesis, Department of Biological Chemistry, Institute for Advanced Chemistry of Catalonia (IQAC-CSIC), Barcelona, Spain. Electronic address: amadeu.llebaria@iqac.csic.es.

Ralf Jockers (R)

Université Paris Cité, Institut Cochin, INSERM, CNRS, 75014 PARIS, France. Electronic address: ralf.jockers@inserm.fr.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Mitochondria-targeted melatonin photorelease...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Mitochondria-targeted melatonin photorelease...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Mitochondria-targeted melatonin photorelease...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs couplés aux protéines G › Récepteur de la mélatonine de type MT1 › Mitochondria-targeted melatonin photorelease...
questionsmedicales.fr › Mélatonine › Mitochondria-targeted melatonin photorelease...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules HEK293 › Mitochondria-targeted melatonin photorelease...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs couplés aux protéines G › Mitochondria-targeted melatonin photorelease...
questionsmedicales.fr › Cellules › Structures cellulaires › Fractions subcellulaires › Mitochondries › Mitochondria-targeted melatonin photorelease...
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiologiques respiratoires › Respiration › Mitochondria-targeted melatonin photorelease...