ESCRT-dependent control of craniofacial morphogenesis with concomitant perturbation of NOTCH signaling.
Craniofacial
ESCRT
Lower jaw
Mouse
NOTCH signaling
Vps25
Journal
Developmental biology
ISSN: 1095-564X
Titre abrégé: Dev Biol
Pays: United States
ID NLM: 0372762
Informations de publication
Date de publication:
11 2023
11 2023
Historique:
received:
12
05
2023
revised:
08
08
2023
accepted:
09
08
2023
medline:
18
9
2023
pubmed:
13
8
2023
entrez:
12
8
2023
Statut:
ppublish
Résumé
Craniofacial development is orchestrated by transcription factor-driven regulatory networks, epigenetic modifications, and signaling pathways. Signaling molecules and their receptors rely on endo-lysosomal trafficking to prevent accumulation on the plasma membrane. ESCRT (Endosomal Sorting Complexes Required for Transport) machinery is recruited to endosomal membranes enabling degradation of such endosomal cargoes. Studies in vitro and in invertebrate models established the requirements of the ESCRT machinery in membrane remodeling, endosomal trafficking, and lysosomal degradation of activated membrane receptors. However, investigations during vertebrate development have been scarce. By ENU-induced mutagenesis, we isolated a mouse line, Vps25
Identifiants
pubmed: 37573008
pii: S0012-1606(23)00141-0
doi: 10.1016/j.ydbio.2023.08.002
pii:
doi:
Substances chimiques
Endosomal Sorting Complexes Required for Transport
0
Carrier Proteins
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
25-42Subventions
Organisme : NIDCR NIH HHS
ID : R01 DE028753
Pays : United States
Informations de copyright
Copyright © 2023. Published by Elsevier Inc.