Calcineurin-mediated dephosphorylation enhances the stability and transactivation of c-Myc.

Humans Mice Animals Calcineurin / genetics Transcriptional Activation Transcription Factors / metabolism Gene Expression Regulation Protein Processing, Post-Translational

Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
12 08 2023
Historique:
received: 01 03 2023
accepted: 09 08 2023
medline: 16 8 2023
pubmed: 13 8 2023
entrez: 12 8 2023
Statut: epublish

Résumé

c-Myc, a transcription factor, induces cell proliferation and is often aberrantly or highly expressed in cancers. However, molecular mechanisms underlying this aberrantly high expression remain unclear. Here, we found that intracellular Ca

Identifiants

DOI: 10.1038/s41598-023-40412-1 PMID: 37573463 PMC: PMC10423207
pubmed: 37573463
doi: 10.1038/s41598-023-40412-1
pii: 10.1038/s41598-023-40412-1
pmc: PMC10423207
doi:

Substances chimiques

Calcineurin EC 3.1.3.16
Transcription Factors 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

13116

Informations de copyright

© 2023. Springer Nature Limited.

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Auteurs

Takahiro Masaki (T)

Department of Veterinary Biochemistry, Joint Faculty of Veterinary Science, Yamaguchi University, 1677-1 Yoshida, Yamaguchi, 753-8511, Japan.

Makoto Habara (M)

Department of Veterinary Biochemistry, Joint Faculty of Veterinary Science, Yamaguchi University, 1677-1 Yoshida, Yamaguchi, 753-8511, Japan.

Shunsuke Hanaki (S)

Department of Veterinary Biochemistry, Joint Faculty of Veterinary Science, Yamaguchi University, 1677-1 Yoshida, Yamaguchi, 753-8511, Japan.

Yuki Sato (Y)

Department of Veterinary Biochemistry, Joint Faculty of Veterinary Science, Yamaguchi University, 1677-1 Yoshida, Yamaguchi, 753-8511, Japan.

Haruki Tomiyasu (H)

Department of Veterinary Biochemistry, Joint Faculty of Veterinary Science, Yamaguchi University, 1677-1 Yoshida, Yamaguchi, 753-8511, Japan.

Yosei Miki (Y)

Department of Veterinary Biochemistry, Joint Faculty of Veterinary Science, Yamaguchi University, 1677-1 Yoshida, Yamaguchi, 753-8511, Japan.

Midori Shimada (M)

Department of Veterinary Biochemistry, Joint Faculty of Veterinary Science, Yamaguchi University, 1677-1 Yoshida, Yamaguchi, 753-8511, Japan. shimada@yamaguchi-u.ac.jp.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Calcineurin-mediated dephosphorylation...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Calcineurin-mediated dephosphorylation...
questionsmedicales.fr › Eucaryotes › Animaux › Calcineurin-mediated dephosphorylation...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Phosphoprotein Phosphatases › Calcineurine › Calcineurin-mediated dephosphorylation...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Activation de la transcription › Calcineurin-mediated dephosphorylation...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Calcineurin-mediated dephosphorylation...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Calcineurin-mediated dephosphorylation...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Modification traductionnelle des protéines › Maturation post-traductionnelle des protéines › Calcineurin-mediated dephosphorylation...