Tumor microenvironment-derived monoacylglycerol lipase provokes tumor-specific immune responses and lipid profiles.

Mice Animals Monoacylglycerol Lipases / genetics Tumor Microenvironment Fatty Acids Neoplasms Mice, Inbred C57BL
(lyso)phospholipids Endocannabinoids Melanoma Monoacylglycerol lipase Non-small cell lung cancer Tumor microenvironment

Journal

Prostaglandins, leukotrienes, and essential fatty acids
ISSN: 1532-2823
Titre abrégé: Prostaglandins Leukot Essent Fatty Acids
Pays: Scotland
ID NLM: 8802730

Informations de publication

Date de publication:
09 2023
Historique:
received: 26 04 2023
revised: 02 08 2023
accepted: 08 08 2023
medline: 8 9 2023
pubmed: 14 8 2023
entrez: 13 8 2023
Statut: ppublish

Résumé

We recently described that monoacylglycerol lipase (MGL) is present in the tumor microenvironment (TME), increasing tumor growth. In this study we compare the implications of MGL deficiency in the TME in different tumor types. We show that subcutaneous injection of KP (Kras

Identifiants

DOI: 10.1016/j.plefa.2023.102585 PMID: 37573716
pubmed: 37573716
pii: S0952-3278(23)00054-6
doi: 10.1016/j.plefa.2023.102585
pii:
doi:

Substances chimiques

Monoacylglycerol Lipases EC 3.1.1.23
Fatty Acids 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

102585

Informations de copyright

Copyright © 2023. Published by Elsevier Ltd.

Déclaration de conflit d'intérêts

Declaration of Competing Interest The authors report no conflict of interest

Auteurs

Eva Gruden (E)

Otto Loewi Research Center, Division of Pharmacology, Medical University of Graz, Austria.

Melanie Kienzl (M)

Otto Loewi Research Center, Division of Pharmacology, Medical University of Graz, Austria. Electronic address: melanie.kienzl@medunigraz.at.

Carina Hasenoehrl (C)

Otto Loewi Research Center, Division of Pharmacology, Medical University of Graz, Austria.

Arailym Sarsembayeva (A)

Otto Loewi Research Center, Division of Pharmacology, Medical University of Graz, Austria.

Dusica Ristic (D)

Otto Loewi Research Center, Division of Pharmacology, Medical University of Graz, Austria.

Sophie Theresa Schmid (ST)

Otto Loewi Research Center, Division of Pharmacology, Medical University of Graz, Austria.

Kathrin Maitz (K)

Otto Loewi Research Center, Division of Pharmacology, Medical University of Graz, Austria.

Ulrike Taschler (U)

Institute of Molecular Biosciences, University of Graz, Graz, Austria.

Lisa Hahnefeld (L)

Institute of Clinical Pharmacology, Goethe University, 60590 Frankfurt/Main, Germany; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, and Fraunhofer Cluster of Excellence for Immune Mediated Diseases CIMD, Theodor-Stern-Kai 7, 60596 Frankfurt am Main, Germany.

Robert Gurke (R)

Institute of Clinical Pharmacology, Goethe University, 60590 Frankfurt/Main, Germany; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, and Fraunhofer Cluster of Excellence for Immune Mediated Diseases CIMD, Theodor-Stern-Kai 7, 60596 Frankfurt am Main, Germany.

Dominique Thomas (D)

Institute of Clinical Pharmacology, Goethe University, 60590 Frankfurt/Main, Germany; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, and Fraunhofer Cluster of Excellence for Immune Mediated Diseases CIMD, Theodor-Stern-Kai 7, 60596 Frankfurt am Main, Germany.

Julia Kargl (J)

Otto Loewi Research Center, Division of Pharmacology, Medical University of Graz, Austria.

Rudolf Schicho (R)

Otto Loewi Research Center, Division of Pharmacology, Medical University of Graz, Austria.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Tumor microenvironment-derived...
questionsmedicales.fr › Eucaryotes › Animaux › Tumor microenvironment-derived...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Esterases › Carboxylic ester hydrolases › Acylglycerol lipase › Tumor microenvironment-derived...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Microenvironnement cellulaire › Microenvironnement tumoral › Tumor microenvironment-derived...
questionsmedicales.fr › Lipides › Acides gras › Tumor microenvironment-derived...
questionsmedicales.fr › Tumeurs › Tumor microenvironment-derived...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Tumor microenvironment-derived...