Impact of transcutaneous vagus nerve stimulation on healthy cognitive and brain aging.
aging
autonomic
brain
cognitive
inflammation
tVNS
transcutaneous vagus nerve stimulation
vagus
Journal
Frontiers in neuroscience
ISSN: 1662-4548
Titre abrégé: Front Neurosci
Pays: Switzerland
ID NLM: 101478481
Informations de publication
Date de publication:
2023
2023
Historique:
received:
10
03
2023
accepted:
02
05
2023
medline:
14
8
2023
pubmed:
14
8
2023
entrez:
14
8
2023
Statut:
epublish
Résumé
Evidence for clinically meaningful benefits of transcutaneous vagus nerve stimulation (VNS) has been rapidly accumulating over the past 15 years. This relatively novel non-invasive brain stimulation technique has been applied to a wide range of neuropsychiatric disorders including schizophrenia, obsessive compulsive disorder, panic disorder, post-traumatic stress disorder, bipolar disorder, and Alzheimer's disease. More recently, non-invasive forms of VNS have allowed for investigations within healthy aging populations. These results offer insight into protocol considerations specific to older adults and how to translate those results into effective clinical trials and, ultimately, effective clinical care. In this review, we characterize the possible mechanisms by which non-invasive VNS may promote healthy aging (e.g., neurotransmitter effects, inflammation regulation, functional connectivity changes), special considerations for applying non-invasive VNS in an older adult population (e.g., vagus nerve changes with age), and how non-invasive VNS may be used in conjunction with existing behavioral interventions (e.g., cognitive behavioral therapy, cognitive training) to promote healthy emotional and cognitive aging.
Identifiants
pubmed: 37575296
doi: 10.3389/fnins.2023.1184051
pmc: PMC10416636
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
1184051Informations de copyright
Copyright © 2023 Trifilio, Shortell, Olshan, O’Neal, Coyne, Lamb, Porges and Williamson.
Déclaration de conflit d'intérêts
JW, EP, and DL are on the scientific advisory board for Evren Technologies, a company developing a closed loop transcutaneous vagus nerve stimulation device based on a patent held by the University of Florida (JW, DL, and EP inventors). EP, DL, and JW have an additional patent under development via the University of Florida related to an implementation technology associated with vagus nerve stimulation. No resources from Evren were used in the current study. No studies involving Evren technology were reviewed. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Neurosci Biobehav Rev. 2017 Mar;74(Pt B):393-400
pubmed: 27131968
Sleep Med Rev. 2015 Feb;19:29-38
pubmed: 24846773
BMJ Open. 2015 Dec 21;5(12):e008853
pubmed: 26692556
Psychiatry Clin Neurosci. 2017 Jan;71(1):18-27
pubmed: 27685435
Neurochem Res. 2008 May;33(5):814-9
pubmed: 17940879
Muscle Nerve. 2019 Apr;59(4):486-491
pubmed: 30636343
Glob Heart. 2020 Oct 21;15(1):71
pubmed: 33150136
Nat Rev Neurol. 2011 May 03;7(6):323-31
pubmed: 21537355
Brain Stimul. 2019 Jan - Feb;12(1):19-29
pubmed: 30337243
J Anat. 1990 Dec;173:169-76
pubmed: 2074222
Sleep Med. 2019 May;57:15-20
pubmed: 30897451
J Nucl Med. 2016 Feb;57(2):221-5
pubmed: 26609179
Acta Neuropathol. 2021 May;141(5):631-650
pubmed: 33427939
Neuroimage. 2002 Nov;17(3):1394-402
pubmed: 12414279
Neurosci Lett. 1985 Jan 7;53(1):15-20
pubmed: 3991047
Brain Stimul. 2020 Jul - Aug;13(4):970-978
pubmed: 32380448
PLoS One. 2018 Nov 28;13(11):e0207281
pubmed: 30485375
Sci Rep. 2020 Oct 16;10(1):17576
pubmed: 33067477
Neuroimage. 2013 Sep;78:75-82
pubmed: 23587685
J Clin Neurosci. 2021 Aug;90:359-362
pubmed: 34275575
Br J Psychiatry. 2021 Mar;218(3):174
pubmed: 33557972
J Physiol. 2021 Apr;599(7):2075-2084
pubmed: 33491187
Auton Neurosci. 2010 Feb 16;153(1-2):90-8
pubmed: 19665435
Neuropsychology. 2021 May;35(4):352-365
pubmed: 34043386
Brain. 2020 May 1;143(5):1588-1602
pubmed: 32380523
Arch Gen Psychiatry. 2012 May;69(5):493-8
pubmed: 22566581
PLoS One. 2012;7(4):e31933
pubmed: 22485128
Brain Res Rev. 2008 Jun;58(1):1-17
pubmed: 18199483
J Alzheimers Dis. 2019;67(3):911-921
pubmed: 30689583
J Neurochem. 2017 Dec 21;:
pubmed: 29266221
Muscle Nerve. 2018 May;57(5):766-771
pubmed: 29053902
Front Neurosci. 2020 May 25;14:523
pubmed: 32523510
J Alzheimers Dis Rep. 2018 Mar 6;2(1):55-65
pubmed: 30480249
Psychophysiology. 2021 Jul;58(7):e13804
pubmed: 33723899
Cortex. 2017 Jul;92:95-102
pubmed: 28460255
Neuroscience. 2015 Nov 19;309:29-50
pubmed: 26306871
Front Hum Neurosci. 2021 Mar 23;14:568051
pubmed: 33854421
Neurosci Biobehav Rev. 2019 Mar;98:306-319
pubmed: 30625337
Front Med (Lausanne). 2017 Jul 31;4:124
pubmed: 28824913
Neurobiol Aging. 2015 May;36(5):1860-7
pubmed: 25805212
Brain Stimul. 2019 Jul - Aug;12(4):911-921
pubmed: 30803865
J Neurosci. 2011 Nov 16;31(46):16556-60
pubmed: 22090482
Brain Stimul. 2013 Sep;6(5):798-804
pubmed: 23453934
Neuroscience. 2005;132(4):1103-13
pubmed: 15857714
Sleep Med Rev. 2016 Oct;29:52-62
pubmed: 26606319
Curr Opin Neurobiol. 2015 Dec;35:87-94
pubmed: 26241632
Eur J Nucl Med Mol Imaging. 2015 Apr;42(5):716-24
pubmed: 25631614
Sleep. 2013 Jul 01;36(7):1027-1032
pubmed: 23814339
N Engl J Med. 1992 Dec 10;327(24):1735-9
pubmed: 1304738
Brain Stimul. 2015 May-Jun;8(3):624-36
pubmed: 25573069
Neuromodulation. 2022 Apr;25(3):424-432
pubmed: 35396072
Neurosci Biobehav Rev. 2002 Nov;26(7):819-25
pubmed: 12470693
Psychol Aging. 2019 Feb;34(1):17-24
pubmed: 30211596
Curr Opin Neurobiol. 2014 Oct;28:22-7
pubmed: 24981873
Front Aging Neurosci. 2021 Feb 03;12:587104
pubmed: 33613261
Biol Psychiatry. 2016 Feb 15;79(4):266-73
pubmed: 25963932
Nature. 2002 Dec 19-26;420(6917):853-9
pubmed: 12490958
Trends Cogn Sci. 2016 Mar;20(3):214-226
pubmed: 26895736
Biol Sex Differ. 2019 Jan 14;10(1):5
pubmed: 30642393
Front Hum Neurosci. 2018 Jun 21;12:202
pubmed: 29977196
Eur J Neurosci. 1995 Jul 1;7(7):1502-11
pubmed: 7551176
Eur J Neurosci. 2021 Oct;54(8):6948-6959
pubmed: 33190318
J Comp Neurol. 1989 Sep 15;287(3):357-72
pubmed: 2570793
Curr Alzheimer Res. 2014;11(10):992-1001
pubmed: 25387337
Neurotherapeutics. 2023 Mar;20(2):419-430
pubmed: 36477709
Neuropsychologia. 2008;46(6):1624-35
pubmed: 18206188
Brain Stimul. 2022 Jul-Aug;15(4):946-956
pubmed: 35738468
Sci Rep. 2018 May 22;8(1):7997
pubmed: 29789596
Int J Psychophysiol. 2005 Apr;56(1):37-43
pubmed: 15725488
Neuromodulation. 2017 Apr;20(3):290-300
pubmed: 27898202
Brain Stimul. 2017 Jan - Feb;10(1):19-27
pubmed: 28104084
Sci Rep. 2021 Nov 2;11(1):21470
pubmed: 34728681
Sleep Med Clin. 2017 Jun;12(2):161-166
pubmed: 28477771
Biomed Tech (Berl). 2008 Jun;53(3):104-11
pubmed: 18601618
J Am Heart Assoc. 2016 Feb 12;5(2):
pubmed: 26873682
Lab Invest. 2017 Jan;97(1):4-13
pubmed: 27869795
Neurosci Biobehav Rev. 2017 Mar;74(Pt B):366-375
pubmed: 27208411
Neuropsychologia. 2018 Mar;111:72-76
pubmed: 29326067
Nat Neurosci. 2001 Jul;4(7):732-8
pubmed: 11426230
Biol Psychiatry Cogn Neurosci Neuroimaging. 2017 Jan;2(1):38-44
pubmed: 28217759
Neuropsychol Rev. 2018 Dec;28(4):393-416
pubmed: 30536144
Neurosci Lett. 2019 Jun 11;703:104-110
pubmed: 30904576
Front Psychiatry. 2017 Sep 15;8:154
pubmed: 28966597
Psychon Bull Rev. 2017 Aug;24(4):1282-1311
pubmed: 28108977
Neurology. 2006 Jan 24;66(2):236-8
pubmed: 16434661
JAMA Neurol. 2013 Mar 1;70(3):374-82
pubmed: 23599941
Nat Rev Neurosci. 2018 Nov;19(11):701-710
pubmed: 30305711
J Comp Neurol. 1995 Jul 17;358(1):79-87
pubmed: 7560278
Neuropsychopharmacology. 2022 Apr;47(5):1106-1113
pubmed: 35034099
Brain Res Bull. 2020 Feb;155:37-47
pubmed: 31790720
Brain Stimul. 2022 Nov-Dec;15(6):1405-1414
pubmed: 36150665
Nat Commun. 2018 Jun 5;9(1):2181
pubmed: 29872139
J Comp Neurol. 2007 Sep 1;504(1):74-88
pubmed: 17614301
Clin Cornerstone. 2004;6 Suppl 1A:S16-28
pubmed: 15259536
Brain Stimul. 2018 May - Jun;11(3):492-500
pubmed: 29361441
Neurotherapeutics. 2017 Jul;14(3):716-727
pubmed: 28585221
J Peripher Nerv Syst. 2007 Sep;12(3):205-9
pubmed: 17868247
Sleep Med Rev. 2020 Aug;52:101308
pubmed: 32302775
Neuromodulation. 2016 Apr;19(3):283-90
pubmed: 26990318
Nat Rev Immunol. 2009 Jun;9(6):418-28
pubmed: 19461672
Front Psychol. 2022 Nov 11;13:1003411
pubmed: 36438376
Neurobiol Learn Mem. 2013 Feb;100:56-63
pubmed: 23246466
J Neural Transm (Vienna). 2007;114(11):1485-93
pubmed: 17564758