Targeted genome mining for microbial antitumor agents acting through DNA intercalation.
Biosynthetic gene clusters
DNA intercalator
Genome mining
Microbial natural product
Tetracycline
UvrA-like protein
Journal
Synthetic and systems biotechnology
ISSN: 2405-805X
Titre abrégé: Synth Syst Biotechnol
Pays: China
ID NLM: 101694371
Informations de publication
Date de publication:
Sep 2023
Sep 2023
Historique:
received:
24
06
2023
revised:
18
07
2023
accepted:
18
07
2023
medline:
14
8
2023
pubmed:
14
8
2023
entrez:
14
8
2023
Statut:
epublish
Résumé
Microbial natural products have been one of the most important sources for drug development. In the current postgenomic era, sequence-driven approaches for natural product discovery are becoming increasingly popular. Here, we develop an effective genome mining strategy for the targeted discovery of microbial metabolites with antitumor activities. Our method employs
Identifiants
pubmed: 37575356
doi: 10.1016/j.synbio.2023.07.003
pii: S2405-805X(23)00057-1
pmc: PMC10413001
doi:
Types de publication
Journal Article
Langues
eng
Pagination
520-526Informations de copyright
© 2023 The Authors.
Références
Appl Microbiol Biotechnol. 2006 Nov;73(1):122-31
pubmed: 16810496
Chem Rev. 2006 Aug;106(8):3468-96
pubmed: 16895337
Nat Chem Biol. 2015 Sep;11(9):625-31
pubmed: 26284661
Nat Chem Biol. 2020 Jan;16(1):60-68
pubmed: 31768033
ACS Chem Biol. 2015 Dec 18;10(12):2841-2849
pubmed: 26458099
Nature. 2018 Jul;559(7714):415-418
pubmed: 29995859
J Am Chem Soc. 2010 Mar 3;132(8):2469-93
pubmed: 20121095
Org Lett. 2017 Oct 20;19(20):5617-5620
pubmed: 28971684
Chem Sci. 2018 May 3;9(21):4898-4908
pubmed: 29910943
Chem Biol. 2004 Jan;11(1):21-32
pubmed: 15112992
Nat Rev Drug Discov. 2021 Mar;20(3):200-216
pubmed: 33510482
Nucleic Acids Res. 2021 Jan 8;49(D1):D1020-D1028
pubmed: 33270901
J Nat Prod. 2020 Mar 27;83(3):770-803
pubmed: 32162523
Methods Mol Biol. 2011;731:237-45
pubmed: 21516412
Nat Prod Rep. 2007 Feb;24(1):109-26
pubmed: 17268609
Curr Opin Microbiol. 2018 Oct;45:100-108
pubmed: 29642052
Mol Microbiol. 2022 Jun;117(6):1434-1446
pubmed: 35534931
Methods Mol Biol. 2014;1116:235-44
pubmed: 24395368
Nat Biotechnol. 2013 Oct;31(10):922-7
pubmed: 24056948
Nat Prod Rep. 2020 Jul 1;37(7):879-892
pubmed: 31912842
Cell. 2015 Dec 3;163(6):1297-300
pubmed: 26638061
Nat Chem Biol. 2006 Aug;2(8):423-8
pubmed: 16799553
Nucleic Acids Res. 2020 Jul 2;48(W1):W546-W552
pubmed: 32427317
Chem Rev. 2006 Feb;106(2):233-52
pubmed: 16464004
FEMS Microbiol Lett. 2000 May 1;186(1):61-5
pubmed: 10779713
Appl Environ Microbiol. 2006 Apr;72(4):2573-80
pubmed: 16597959
Appl Microbiol Biotechnol. 2020 Sep;104(18):7701-7721
pubmed: 32686008
Nucleic Acids Res. 2021 Jul 2;49(W1):W29-W35
pubmed: 33978755
FEMS Microbiol Lett. 1998 Nov 15;168(2):243-9
pubmed: 9835035