T-cell Large Granular Lymphocytic Leukemia and Felty Syndrome in Rheumatoid Arthritis: A Case Report.
felty’s syndrome
large granular lymphocytic leukemia
lgl leukemia
neutropenia
rheumatoid arthritis
t-cell leukemia
Journal
Cureus
ISSN: 2168-8184
Titre abrégé: Cureus
Pays: United States
ID NLM: 101596737
Informations de publication
Date de publication:
Jul 2023
Jul 2023
Historique:
accepted:
12
07
2023
medline:
14
8
2023
pubmed:
14
8
2023
entrez:
14
8
2023
Statut:
epublish
Résumé
T-cell large granular lymphocytic (LGL) leukemia is characterized by a clonal proliferation of CD3+ T-cells and has been associated with rheumatoid arthritis (RA). Splenomegaly is a common finding and a majority of cases present with cytopenia. Felty syndrome (FS) is characterized by neutropenia and splenomegaly and is also classically described in the literature for its association with RA. Similarities in clinical features, pathogenesis, management, genetics, and immunologic basis of FS and T-cell LGL leukemia have led to the suggestion that they exist on the same spectrum of disease. We present a case of T-cell LGL leukemia in an RA patient with clinical features not distinguishable from features of FS.
Identifiants
pubmed: 37575786
doi: 10.7759/cureus.41780
pmc: PMC10419330
doi:
Types de publication
Case Reports
Langues
eng
Pagination
e41780Informations de copyright
Copyright © 2023, Prasad et al.
Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
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