Biallelic truncating variants in children with titinopathy represent a recognizable condition with distinctive muscular and cardiac characteristics: a report on five patients.

children dilated cardiomyopathy heart failure neuromuscular disease titin (TTN) titinopathy truncating variant

Journal

Frontiers in cardiovascular medicine
ISSN: 2297-055X
Titre abrégé: Front Cardiovasc Med
Pays: Switzerland
ID NLM: 101653388

Informations de publication

Date de publication:
2023
Historique:
received: 22 04 2023
accepted: 10 07 2023
medline: 14 8 2023
pubmed: 14 8 2023
entrez: 14 8 2023
Statut: epublish

Résumé

Monoallelic and biallelic We reviewed the medical records of pediatric patients with biallelic Five pediatric patients (four male) with biallelic Biallelic

Sections du résumé

Background UNASSIGNED
Monoallelic and biallelic
Methods UNASSIGNED
We reviewed the medical records of pediatric patients with biallelic
Results UNASSIGNED
Five pediatric patients (four male) with biallelic
Conclusion UNASSIGNED
Biallelic

Identifiants

pubmed: 37576110
doi: 10.3389/fcvm.2023.1210378
pmc: PMC10415037
doi:

Types de publication

Journal Article

Langues

eng

Pagination

1210378

Informations de copyright

© 2023 Baban, Cicenia, Magliozzi, Parlapiano, Cirillo, Pascolini, Fattori, Gnazzo, Bruno, De Luca, Di Chiara, Francalanci, Udd, Secinaro, Amodeo, Bertini, Savarese, Drago and Novelli.

Déclaration de conflit d'intérêts

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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Auteurs

Anwar Baban (A)

Pediatric Cardiology and Arrhythmia/Syncope Complex Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.

Marianna Cicenia (M)

Pediatric Cardiology and Arrhythmia/Syncope Complex Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.

Monia Magliozzi (M)

Laboratory of Medical Genetics, Translational Cytogenomics Research Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.

Giovanni Parlapiano (G)

Pediatric Cardiology and Arrhythmia/Syncope Complex Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Laboratory of Medical Genetics, Translational Cytogenomics Research Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.

Marco Cirillo (M)

Department of Imaging, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.

Giulia Pascolini (G)

Pediatric Cardiology and Arrhythmia/Syncope Complex Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Laboratory of Medical Genetics, Translational Cytogenomics Research Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.

Fabiana Fattori (F)

Unit of Muscular and Neurodegenerative Disorders, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.

Maria Gnazzo (M)

Translational Cytogenomics Research Unit, Bambino Gesù Children's Hospital, Rome, Italy.

Pasqualina Bruno (P)

Department of Cardiac Surgery, Cardiology, Heart and Lung Transplantation, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.

Lorenzo De Luca (L)

Pediatric Cardiology and Arrhythmia/Syncope Complex Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.

Luca Di Chiara (L)

Pediatric Cardiac Intensive Care Unit, Department of Cardiology and Cardiac Surgery, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.

Paola Francalanci (P)

Department of Pathology, Bambino Gesù Children's Hospital and Research Institute, IRCCS, Rome, Italy.

Bjarne Udd (B)

Folkhälsan Research Center, Helsinki, Finland.
Department of Medical Genetics, Medicum, University of Helsinki, Helsinki, Finland.
Department of Neurology, Vaasa Central Hospital, Vaasa, Finland.

Aurelio Secinaro (A)

Advanced Cardiothoracic Imaging Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.

Antonio Amodeo (A)

Heart Failure and Transplant, Mechanical Circulatory Support Complex Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.

Enrico Silvio Bertini (ES)

Unit of Muscular and Neurodegenerative Disorders, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.

Marco Savarese (M)

Folkhälsan Research Center, Helsinki, Finland.
Department of Medical Genetics, Medicum, University of Helsinki, Helsinki, Finland.

Fabrizio Drago (F)

Pediatric Cardiology and Arrhythmia/Syncope Complex Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.

Antonio Novelli (A)

Laboratory of Medical Genetics, Translational Cytogenomics Research Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.

Classifications MeSH