The role of ferroptosis in intervertebral disc degeneration.
antioxidant system
epigenetics
ferroptosis
intervertebral disc degeneration
lipid peroxidation
reactive oxygen species
Journal
Frontiers in cell and developmental biology
ISSN: 2296-634X
Titre abrégé: Front Cell Dev Biol
Pays: Switzerland
ID NLM: 101630250
Informations de publication
Date de publication:
2023
2023
Historique:
received:
12
05
2023
accepted:
17
07
2023
medline:
14
8
2023
pubmed:
14
8
2023
entrez:
14
8
2023
Statut:
epublish
Résumé
Nucleus pulposus, annulus fibrosus, and cartilage endplate constitute an avascular intervertebral disc (IVD), which is crucial for spinal and intervertebral joint mobility. As one of the most widespread health issues worldwide, intervertebral disc degeneration (IVDD) is recognized as a key contributor to back and neck discomfort. A number of degenerative disorders have a strong correlation with ferroptosis, a recently identified novel regulated cell death (RCD) characterized by an iron-dependent mechanism and a buildup of lipid reactive oxygen species (ROS). There is growing interest in the part ferroptosis plays in IVDD pathophysiology. Inhibiting ferroptosis has been shown to control IVDD development. Several studies have demonstrated that in TBHP-induced oxidative stress models, changes in ferroptosis marker protein levels and increased lipid peroxidation lead to the degeneration of intervertebral disc cells, which subsequently aggravates IVDD. Similarly, IVDD is significantly relieved with the use of ferroptosis inhibitors. The purpose of this review was threefold: 1) to discuss the occurrence of ferroptosis in IVDD; 2) to understand the mechanism of ferroptosis and its role in IVDD pathophysiology; and 3) to investigate the feasibility and prospect of ferroptosis in IVDD treatment.
Identifiants
pubmed: 37576601
doi: 10.3389/fcell.2023.1219840
pii: 1219840
pmc: PMC10413580
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
1219840Informations de copyright
Copyright © 2023 Fan, Chu, Yu, Ji, Kong, Yao, Wang, Geng, Wu and Mao.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Eur Rev Med Pharmacol Sci. 2020 Mar;24(5):2683-2691
pubmed: 32196619
Front Pharmacol. 2020 Mar 17;11:239
pubmed: 32256352
Theranostics. 2021 Jan 1;11(7):3052-3059
pubmed: 33537073
J Exp Med. 2015 Apr 6;212(4):555-68
pubmed: 25824823
Cancer Lett. 2018 Mar 1;416:124-137
pubmed: 29274359
PLoS Genet. 2019 Sep 30;15(9):e1008396
pubmed: 31568497
Cell Death Discov. 2021 Sep 7;7(1):235
pubmed: 34493702
ACS Chem Biol. 2017 Oct 20;12(10):2538-2545
pubmed: 28837769
J Biol Chem. 1999 Jan 29;274(5):3009-16
pubmed: 9915839
Cell. 2019 May 16;177(5):1262-1279.e25
pubmed: 31056284
J Gene Med. 2023 Jun;25(6):e3488
pubmed: 36813742
Cancer Commun (Lond). 2018 Apr 25;38(1):12
pubmed: 29764521
J Biol Chem. 2017 Aug 4;292(31):12764-12771
pubmed: 28615454
Cell. 2018 Jan 25;172(3):409-422.e21
pubmed: 29290465
Oxid Med Cell Longev. 2021 Oct 14;2021:5620475
pubmed: 34691358
J Cell Physiol. 2020 Nov;235(11):8402-8415
pubmed: 32239675
Lipids. 2004 Apr;39(4):293-309
pubmed: 15357017
J Biol Chem. 2021 Sep;297(3):101032
pubmed: 34339740
Cell Death Dis. 2022 Mar 7;13(3):212
pubmed: 35256587
Antioxid Redox Signal. 2002 Aug;4(4):603-14
pubmed: 12230872
Osteoarthritis Cartilage. 2009 Jun;17(6):766-71
pubmed: 19073367
Mol Cell Oncol. 2015 May 26;2(4):e1054549
pubmed: 27308510
Swiss Med Wkly. 2006 Dec 2;136(47-48):745-56
pubmed: 17225194
Cell Cycle. 2023 May;22(10):1196-1214
pubmed: 37055945
Cell Death Dis. 2016 Jul 21;7:e2307
pubmed: 27441659
Nat Chem Biol. 2019 Dec;15(12):1137-1147
pubmed: 31740834
Nat Chem Biol. 2017 Jan;13(1):91-98
pubmed: 27842070
Biochemistry. 2020 Feb 11;59(5):637-638
pubmed: 32003211
Biochem Biophys Res Commun. 2023 Feb 12;644:8-14
pubmed: 36621150
Biomaterials. 2021 Oct;277:121110
pubmed: 34482088
Bioorg Med Chem. 2006 Jun 15;14(12):4295-301
pubmed: 16500106
Commun Biol. 2018 Nov 28;1:210
pubmed: 30511023
Oxid Med Cell Longev. 2021 Feb 10;2021:6670497
pubmed: 33628376
Int J Mol Sci. 2020 Jul 11;21(14):
pubmed: 32664576
ACS Cent Sci. 2018 Mar 28;4(3):387-396
pubmed: 29632885
Signal Transduct Target Ther. 2021 Feb 3;6(1):49
pubmed: 33536413
Nat Rev Rheumatol. 2022 Jan;18(1):47-60
pubmed: 34845360
Nature. 2019 Nov;575(7784):693-698
pubmed: 31634899
Oxid Med Cell Longev. 2022 Feb 21;2022:6041612
pubmed: 35237382
Biomaterials. 2021 Jan;268:120537
pubmed: 33260096
Prog Retin Eye Res. 2020 Nov;79:100849
pubmed: 32169632
Redox Biol. 2015 Dec;6:297-310
pubmed: 26298204
J Hematol Oncol. 2019 Mar 29;12(1):34
pubmed: 30925886
EMBO J. 2017 Jul 3;36(13):1811-1836
pubmed: 28596378
Lancet. 2021 Jul 3;398(10294):78-92
pubmed: 34115979
Mol Med. 2021 Sep 8;27(1):103
pubmed: 34496740
Int J Nanomedicine. 2021 Dec 14;16:8049-8065
pubmed: 34938072
Biochem J. 2000 Apr 1;347 Pt 1:1-16
pubmed: 10727395
Neural Regen Res. 2023 Mar;18(3):626-633
pubmed: 36018187
Life Sci. 2020 Sep 1;256:117917
pubmed: 32525001
Trends Cell Biol. 2020 Jun;30(6):478-490
pubmed: 32413317
J Cell Physiol. 2021 Apr;236(4):2725-2739
pubmed: 32892384
Blood Rev. 2009 May;23(3):95-104
pubmed: 18835072
Exp Mol Pathol. 2021 Feb;118:104570
pubmed: 33166496
J Am Chem Soc. 2014 Mar 26;136(12):4551-6
pubmed: 24592866
Am J Clin Nutr. 2017 Dec;106(Suppl 6):1559S-1566S
pubmed: 29070551
Nature. 2012 Sep 6;489(7414):101-8
pubmed: 22955620
Eur J Neurosci. 2023 Jul;58(1):2194-2214
pubmed: 37161649
Proc Natl Acad Sci U S A. 2019 Feb 19;116(8):2996-3005
pubmed: 30718432
J Biol Chem. 2018 Jun 15;293(24):9248-9264
pubmed: 29724825
Food Chem. 2017 Oct 1;232:733-743
pubmed: 28490135
Cells. 2021 Mar 12;10(3):
pubmed: 33809182
Ageing Res Rev. 2021 Dec;72:101481
pubmed: 34606985
Lancet. 2017 Sep 16;390(10100):1211-1259
pubmed: 28919117
Autophagy. 2021 Sep;17(9):2054-2081
pubmed: 32804006
Cell Prolif. 2023 Mar;56(3):e13368
pubmed: 36450665
Dev Cell. 2018 Jan 8;44(1):97-112.e7
pubmed: 29275994
J Inorg Biochem. 2021 Oct;223:111537
pubmed: 34273716
Free Radic Biol Med. 2019 Mar;133:162-168
pubmed: 29800655
Int J Mol Sci. 2020 Nov 29;21(23):
pubmed: 33260475
Cancer Res. 2018 Jul 1;78(13):3484-3496
pubmed: 29588351
Cell. 2014 Jan 16;156(1-2):317-331
pubmed: 24439385
Biochem Biophys Res Commun. 2016 Sep 23;478(3):1338-43
pubmed: 27565726
Am J Hum Genet. 1985 Jan;37(1):1-31
pubmed: 3872065
Arterioscler Thromb Vasc Biol. 2010 Jul;30(7):1347-53
pubmed: 20378845
Gut Microbes. 2021 Jan-Dec;13(1):1-21
pubmed: 33779497
Apoptosis. 2023 Aug;28(7-8):1226-1240
pubmed: 37243773
Cell Mol Biol Lett. 2021 Jun 7;26(1):26
pubmed: 34098867
Cell Death Differ. 2019 Nov;26(11):2284-2299
pubmed: 30737476
Lancet. 2018 Nov 10;392(10159):1789-1858
pubmed: 30496104
Chem Biol. 2008 Mar;15(3):234-45
pubmed: 18355723
Biochem Pharmacol. 2017 Sep 15;140:41-52
pubmed: 28595877
Nat Chem Biol. 2020 Dec;16(12):1351-1360
pubmed: 32778843
Transl Stroke Res. 2021 Aug;12(4):615-630
pubmed: 32875455
Cells. 2022 Nov 05;11(21):
pubmed: 36359904
J Bone Miner Res. 2006 Jul;21(7):1003-11
pubmed: 16813521
Transfus Apher Sci. 2018 Aug;57(4):524-531
pubmed: 29859670
Aging Dis. 2022 Apr 1;13(2):552-567
pubmed: 35371598
Cell. 2019 May 16;177(5):1094-1107
pubmed: 31100266
Mol Aspects Med. 2005 Aug-Oct;26(4-5):299-312
pubmed: 16102805
Redox Biol. 2020 Jan;28:101322
pubmed: 31605963
Free Radic Biol Med. 2018 Mar;117:45-57
pubmed: 29378335
Nat Cell Biol. 2014 Dec;16(12):1180-91
pubmed: 25402683
Adv Exp Med Biol. 2014;844:201-25
pubmed: 25480643
Cell Death Differ. 2020 Feb;27(2):662-675
pubmed: 31273299
Nat Commun. 2017 Mar 28;8:14844
pubmed: 28348409
Acta Pharmacol Sin. 2022 Jan;43(1):39-49
pubmed: 33767380
Biochem Biophys Res Commun. 2016 May 13;473(4):775-780
pubmed: 27037021
Cell Metab. 2015 Nov 3;22(5):777-87
pubmed: 26437604
J Cell Mol Med. 2017 Apr;21(4):648-657
pubmed: 27860262
Trends Biochem Sci. 2016 Mar;41(3):274-286
pubmed: 26725301
Front Pharmacol. 2023 Mar 09;14:1067402
pubmed: 36969874
Stem Cell Rev Rep. 2022 Mar;18(3):1127-1142
pubmed: 35257299
Front Cell Dev Biol. 2020 Oct 07;8:590226
pubmed: 33117818
Mol Cell. 2015 Jul 16;59(2):298-308
pubmed: 26166707
Br J Pharmacol. 1997 Apr;120(7):1199-206
pubmed: 9105693
Br J Pharmacol. 2020 Feb;177(3):656-667
pubmed: 31655003
Cell Death Differ. 2018 Aug;25(8):1457-1472
pubmed: 29348676
Lancet. 1999 Aug 14;354(9178):581-5
pubmed: 10470716
N Engl J Med. 2005 Mar 10;352(10):1011-23
pubmed: 15758012
J Am Chem Soc. 2012 May 23;134(20):8306-9
pubmed: 22369282
Front Endocrinol (Lausanne). 2022 Oct 20;13:1042060
pubmed: 36339421
Proc Natl Acad Sci U S A. 2016 Aug 23;113(34):E4966-75
pubmed: 27506793
EMBO Mol Med. 2016 Feb 19;8(3):247-67
pubmed: 26896449
Calcif Tissue Int. 2020 Apr;106(4):401-414
pubmed: 31912171
Neuropsychopharmacology. 2013 Jan;38(1):23-38
pubmed: 22781841
Oxid Med Cell Longev. 2020 Feb 25;2020:9349762
pubmed: 32184919
J Biol Chem. 1986 Feb 15;261(5):2256-63
pubmed: 2868011
FASEB J. 2020 Jun;34(6):7915-7926
pubmed: 32293077
Chem Rev. 2014 Sep 24;114(18):9022-46
pubmed: 25180889
Oncotarget. 2016 Nov 15;7(46):74630-74647
pubmed: 27612422
Nat Commun. 2020 Jan 23;11(1):433
pubmed: 31974380
Stem Cells. 2021 Apr;39(4):467-481
pubmed: 33459443
Cell Death Dis. 2018 Sep 26;9(10):1005
pubmed: 30258181
Nat Chem Biol. 2016 Nov;12(11):937-943
pubmed: 27618187
J Cell Physiol. 2019 Jun;234(6):7695-7707
pubmed: 30565676
Redox Biol. 2020 Oct;37:101697
pubmed: 32896720
Cell. 2010 Jul 9;142(1):24-38
pubmed: 20603012
Biochem J. 2016 Mar 15;473(6):769-77
pubmed: 26759376
Blood. 2005 May 15;105(10):4096-102
pubmed: 15692071
Theranostics. 2021 Jan 1;11(1):27-47
pubmed: 33391459
J Immunol Res. 2014;2014:697560
pubmed: 24987711
Front Immunol. 2021 Feb 22;12:603416
pubmed: 33692782
Stem Cell Res Ther. 2021 May 13;12(1):286
pubmed: 33985571
Biochem Biophys Res Commun. 2019 Aug 13;516(1):37-43
pubmed: 31196626
Connect Tissue Res. 2021 May;62(3):337-349
pubmed: 32180463
Eur Rev Med Pharmacol Sci. 2018 Jun;22(12):3826-3836
pubmed: 29949159
Antioxidants (Basel). 2020 Dec 02;9(12):
pubmed: 33276470
Cell Biol Int. 2019 Nov;43(11):1245-1256
pubmed: 30811078
J Inflamm (Lond). 2019 May 29;16:11
pubmed: 31160885
Cell. 2017 Oct 5;171(2):273-285
pubmed: 28985560
Int J Mol Med. 2022 Jun;49(6):
pubmed: 35514314
Nat Cell Biol. 2020 Feb;22(2):225-234
pubmed: 32029897
Cell Death Dis. 2023 Jul 6;14(7):402
pubmed: 37414755
Prog Neurobiol. 2021 Jan;196:101890
pubmed: 32726602
J Am Soc Nephrol. 2020 Feb;31(2):280-296
pubmed: 31767624
Br J Pharmacol. 2010 Oct;161(3):555-70
pubmed: 20880396
Free Radic Biol Med. 2018 Nov 1;127:153-159
pubmed: 29522794
Spine (Phila Pa 1976). 1993 Oct 1;18(13):1761-5
pubmed: 7694378
Eur J Med Chem. 2021 Jan 1;209:112842
pubmed: 33065375
Cells. 2021 Jan 12;10(1):
pubmed: 33445717
J Exp Med. 1944 Feb 1;79(2):137-58
pubmed: 19871359
Int J Mol Sci. 2020 May 20;21(10):
pubmed: 32443722
Cell Mol Biol Lett. 2020 Feb 27;25:10
pubmed: 32161620
Nat Chem Biol. 2017 Jan;13(1):81-90
pubmed: 27842066
Free Radic Biol Med. 2015 Jun;83:77-88
pubmed: 25687825
Cancer Cell. 2019 Jun 10;35(6):830-849
pubmed: 31105042
Basic Res Cardiol. 2018 Aug 9;113(5):37
pubmed: 30094473
Am J Physiol Renal Physiol. 2018 May 1;314(5):F702-F714
pubmed: 28515173
Nat Rev Rheumatol. 2014 Jan;10(1):44-56
pubmed: 24166242
Cell Rep. 2017 Aug 15;20(7):1692-1704
pubmed: 28813679
Science. 2004 Dec 17;306(5704):2090-3
pubmed: 15514116
Biomed Pharmacother. 2022 Sep;153:113363
pubmed: 35834989
Cell Rep. 2020 Dec 8;33(10):108487
pubmed: 33296645
J Adv Res. 2020 Jul 22;28:231-243
pubmed: 33364059
Acta Pharmacol Sin. 2021 Oct;42(10):1690-1702
pubmed: 34112960
Cancer Sci. 2017 Nov;108(11):2187-2194
pubmed: 28837253
ACS Cent Sci. 2017 Mar 22;3(3):232-243
pubmed: 28386601
Free Radic Biol Med. 2020 Nov 20;160:552-565
pubmed: 32896601
Biochem Biophys Res Commun. 2016 Nov 25;480(4):602-607
pubmed: 27793671
Cell Metab. 2005 Mar;1(3):191-200
pubmed: 16054062
Int J Biol Macromol. 2018 Dec;120(Pt A):310-317
pubmed: 30144543
Science. 2018 Mar 30;359(6383):1520-1523
pubmed: 29599243
Ann Rheum Dis. 1993 Jan;52(1):67-73
pubmed: 8427520
Emerg Microbes Infect. 2018 Jan 10;7(1):1
pubmed: 29323102
Cell Death Differ. 2022 Jun;29(6):1164-1175
pubmed: 34839355
Nat Chem Biol. 2006 Aug;2(8):406-14
pubmed: 16850017
Eur Heart J. 2020 Jul 21;41(28):2681-2695
pubmed: 30903157
Eur J Pharmacol. 2019 Oct 15;861:172614
pubmed: 31421090
Nat Chem Biol. 2016 Jul;12(7):497-503
pubmed: 27159577
J Am Chem Soc. 2020 Aug 19;142(33):14331-14342
pubmed: 32698570
Physiol Rev. 2006 Apr;86(2):583-650
pubmed: 16601269
Redox Biol. 2023 Jun;62:102707
pubmed: 37099926
Elife. 2020 Aug 21;9:
pubmed: 32821059
Osteoarthritis Cartilage. 2021 Sep;29(9):1324-1334
pubmed: 34242803
Nat Commun. 2020 Mar 6;11(1):1251
pubmed: 32144268
JOR Spine. 2020 Feb 18;3(1):e1082
pubmed: 32211593
Oxid Med Cell Longev. 2022 Apr 15;2022:4235126
pubmed: 35480873
Cell Death Dis. 2020 Feb 3;11(2):88
pubmed: 32015325
ACS Cent Sci. 2020 Jan 22;6(1):41-53
pubmed: 31989025
Cell. 2017 Oct 19;171(3):628-641.e26
pubmed: 29053969
Nature. 2007 Jun 14;447(7146):864-8
pubmed: 17568748
IUBMB Life. 2017 Jun;69(6):423-434
pubmed: 28276141
J Clin Invest. 2018 Aug 1;128(8):3341-3355
pubmed: 29939160
Proc Natl Acad Sci U S A. 2019 Feb 12;116(7):2672-2680
pubmed: 30692261
Mol Cancer. 2022 Feb 12;21(1):47
pubmed: 35151318
Cell Prolif. 2020 Nov;53(11):e12915
pubmed: 33047870
Oxid Med Cell Longev. 2022 Jun 29;2022:2948090
pubmed: 35814268
J Inflamm Res. 2020 Jul 20;13:325-341
pubmed: 32765041
EBioMedicine. 2019 Oct;48:236-247
pubmed: 31521612
J Med Chem. 2019 Jan 10;62(1):266-275
pubmed: 29688708
J Biol Chem. 2001 Jul 6;276(27):24667-73
pubmed: 11319222
Cell Metab. 2008 Sep;8(3):237-48
pubmed: 18762024
Nutrients. 2018 Aug 21;10(9):
pubmed: 30134611
Theranostics. 2020 Jun 1;10(16):7178-7192
pubmed: 32641986
Ann Rheum Dis. 1998 May;57(5):309-14
pubmed: 9741316
Cell Signal. 2021 Feb;78:109870
pubmed: 33290842
Osteoarthritis Cartilage. 2015 Jul;23(7):1165-77
pubmed: 25748081
Semin Cancer Biol. 2020 Nov;66:89-100
pubmed: 30880243
Cell. 2012 May 25;149(5):1060-72
pubmed: 22632970
Cell Chem Biol. 2019 Mar 21;26(3):420-432.e9
pubmed: 30686757
Amino Acids. 2012 Jan;42(1):231-46
pubmed: 21409388
Cell Prolif. 2021 Jan;54(1):e12941
pubmed: 33111436
Exp Mol Med. 2022 Apr;54(4):518-530
pubmed: 35440754
Gut Microbes. 2021 Jan-Dec;13(1):1-19
pubmed: 33541211
Nat Commun. 2020 Oct 5;11(1):4979
pubmed: 33020468